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. 1991 Dec;59(12):4706–4709. doi: 10.1128/iai.59.12.4706-4709.1991

Experimental Porphyromonas gingivalis infection in nonimmune athymic BALB/c mice.

P B Chen 1, L B Davern 1, A Aguirre 1
PMCID: PMC259103  PMID: 1657788

Abstract

The purpose of this report was to study the role of T lymphocytes following injection of Porphyromonas gingivalis in a mouse abscess model. Three invasive P. gingivalis isolates (ATCC 53977, W83, and AJW4) were injected into athymic BALB/c mice and their heterozygous (nu/+) littermates. The athymic BALB/c (nu/nu) mice were able to localize the invasive P. gingivalis isolates at the injection site. By comparison, the heterozygous BALB/c (nu/+) littermates developed hemorrhagic secondary lesions within 24 h after subcutaneous injection of the same invasive P. gingivalis isolates. These results suggest that naive T lymphocytes may contribute to the pathology associated with P. gingivalis infection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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