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. 1971 Dec;44(3):286–300.

Cytochalasin B reversibly inhibits phagocytosis: functional, metabolic, and ultrastructural effects in human blood leukocytes and rabbit alveolar macrophages.

S E Malawista, J B Gee, K G Bensch
PMCID: PMC2591788  PMID: 5132788

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Selected References

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  1. Allison A. C., Davies P., De Petris S. Role of contractile microfilaments in macrophage movement and endocytosis. Nat New Biol. 1971 Aug 4;232(31):153–155. doi: 10.1038/newbio232153a0. [DOI] [PubMed] [Google Scholar]
  2. Bensch K. G., Malawista S. E. Microtubule crystals: a new biophysical phenomenon induced by Vinca alkaloids. Nature. 1968 Jun 22;218(5147):1176–1177. doi: 10.1038/2181176a0. [DOI] [PubMed] [Google Scholar]
  3. Caner J. E. Colchicine inhibition of chemotaxis. Arthritis Rheum. 1965 Oct;8(5):757–764. doi: 10.1002/art.1780080438. [DOI] [PubMed] [Google Scholar]
  4. Carter S. B. Effects of cytochalasins on mammalian cells. Nature. 1967 Jan 21;213(5073):261–264. doi: 10.1038/213261a0. [DOI] [PubMed] [Google Scholar]
  5. Davis A. T., Estensen R., Quie P. G. Cytochalasin B. 3. Inhibition of human polymorphonuclear leukocyte phagocytosis. Proc Soc Exp Biol Med. 1971 May;137(1):161–164. doi: 10.3181/00379727-137-35535. [DOI] [PubMed] [Google Scholar]
  6. FREEMAN J. A., SPURLOCK B. O. A new epoxy embedment for electron microscopy. J Cell Biol. 1962 Jun;13:437–443. doi: 10.1083/jcb.13.3.437. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Freed J. J., Lebowitz M. M. The association of a class of saltatory movements with microtubules in cultured cells. J Cell Biol. 1970 May;45(2):334–354. doi: 10.1083/jcb.45.2.334. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. GORDON G. B., MILLER L. R., BENSCH K. G. FIXATION OF TISSUE CULTURE CELLS FOR ULTRASTRUCTURAL CYTOCHEMISTRY. Exp Cell Res. 1963 Aug;31:440–443. doi: 10.1016/0014-4827(63)90024-7. [DOI] [PubMed] [Google Scholar]
  9. Gee J. B., Vassallo C. L., Bell P., Kaskin J., Basford R. E., Field J. B. Catalase-dependent peroxidative metabolism in the alveolar macrophage during phagocytosis. J Clin Invest. 1970 Jun;49(6):1280–1287. doi: 10.1172/JCI106340. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Ishikawa H., Bischoff R., Holtzer H. Formation of arrowhead complexes with heavy meromyosin in a variety of cell types. J Cell Biol. 1969 Nov;43(2):312–328. [PMC free article] [PubMed] [Google Scholar]
  11. Ledbetter M. C., Porter K. R. A "MICROTUBULE" IN PLANT CELL FINE STRUCTURE. J Cell Biol. 1963 Oct 1;19(1):239–250. doi: 10.1083/jcb.19.1.239. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. MALAWISTA S. E. ON THE ACTION OF COLCHICINE, THE MELANOCYTE MODEL. J Exp Med. 1965 Aug 1;122:361–384. doi: 10.1084/jem.122.2.361. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Malawista S. E., Bensch K. G. Human polymorphonuclear leukocytes: demonstration of microtubules and effect of colchicine. Science. 1967 Apr 28;156(3774):521–522. doi: 10.1126/science.156.3774.521. [DOI] [PubMed] [Google Scholar]
  14. Malawista S. E., Bodel P. T. The dissociation by colchicine of phagocytosis from increased oxygen consumption in human leukocytes. J Clin Invest. 1967 May;46(5):786–796. doi: 10.1172/JCI105579. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Malawista S. E. Colchicine: a common mechanism for its anti-inflammatory and anti-mitotic effects. Arthritis Rheum. 1968 Apr;11(2):191–197. doi: 10.1002/art.1780110210. [DOI] [PubMed] [Google Scholar]
  16. Malawista S. E. Cytochalasin B reversibly inhibits melanin granule movement in melanocytes. Nature. 1971 Dec 10;234(5328):354–355. doi: 10.1038/234354a0. [DOI] [PubMed] [Google Scholar]
  17. Malawista S. E. Vinblastine: colchicine-like effects on human blood leukocytes during phagocytosis. Blood. 1971 May;37(5):519–529. [PubMed] [Google Scholar]
  18. OREN R., FARNHAM A. E., SAITO K., MILOFSKY E., KARNOVSKY M. L. Metabolic patterns in three types of phagocytizing cells. J Cell Biol. 1963 Jun;17:487–501. doi: 10.1083/jcb.17.3.487. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. PALADE G. E. A study of fixation for electron microscopy. J Exp Med. 1952 Mar;95(3):285–298. doi: 10.1084/jem.95.3.285. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Quie P. G., Kaplan E. L., Page A. R., Gruskay F. L., Malawista S. E. Defective polymorphonuclear-leukocyte function and chronic granulomatous disease in two female children. N Engl J Med. 1968 May 2;278(18):976–980. doi: 10.1056/NEJM196805022781802. [DOI] [PubMed] [Google Scholar]
  21. Schroeder T. E. Cytokinesis: filaments in the cleavage furrow. Exp Cell Res. 1968 Oct;53(1):272–276. doi: 10.1016/0014-4827(68)90373-x. [DOI] [PubMed] [Google Scholar]
  22. Strauss R. R., Paul B. B., Sbarra A. J. Effect of phenylbutazone on phagocytosis and intracellular killing by guinea pig polymorphonuclear leukocytes. J Bacteriol. 1968 Dec;96(6):1982–1990. doi: 10.1128/jb.96.6.1982-1990.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Tilney L. G., Hiramoto Y., Marsland D. Studies on the microtubules in heliozoa. 3. A pressure analysis of the role of these structures in the formation and maintenance of the axopodia of Actinosphaerium nucleofilum (Barrett). J Cell Biol. 1966 Apr;29(1):77–95. doi: 10.1083/jcb.29.1.77. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. VENABLE J. H., COGGESHALL R. A SIMPLIFIED LEAD CITRATE STAIN FOR USE IN ELECTRON MICROSCOPY. J Cell Biol. 1965 May;25:407–408. doi: 10.1083/jcb.25.2.407. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Wessells N. K., Spooner B. S., Ash J. F., Bradley M. O., Luduena M. A., Taylor E. L., Wrenn J. T., Yamada K. Microfilaments in cellular and developmental processes. Science. 1971 Jan 15;171(3967):135–143. doi: 10.1126/science.171.3967.135. [DOI] [PubMed] [Google Scholar]

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