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. 1973 Dec;46(5):337–360.

Ultrastructure and cell biology of pigment cells. Intracellular dynamics and the fine structure of melanocytes with special reference to the effects of MSH and cyclic AMP on microtubules and 10-nm filaments.

G Moellmann, J McGuire, A B Lerner
PMCID: PMC2591998  PMID: 4360457

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abe K., Butcher R. W., Nicholson W. E., Baird C. E., Liddle R. A., Liddle G. W. Adenosine 3',5'-monophosphate (cyclic AMP) as the mediator of the actions of melanocyte stimulating hormone (MSH) and norepinephrine on the frog skin. Endocrinology. 1969 Feb;84(2):362–368. doi: 10.1210/endo-84-2-362. [DOI] [PubMed] [Google Scholar]
  2. Abe K., Robison G. A., Liddle G. W., Butcher R. W., Nicholson W. E., Baird C. E. Role of cyclic AMP in mediating the effects of MSH, norepinephrine, and melatonin on frog skin color. Endocrinology. 1969 Oct;85(4):674–682. doi: 10.1210/endo-85-4-674. [DOI] [PubMed] [Google Scholar]
  3. Ahmed M., Korol W., Larson D., Molnar H., Schidlovsky G. Transformation of rat mammary cell cultures by R-35 virus isolated from spontaneous rat mammary adenocarcinoma. J Natl Cancer Inst. 1972 Apr;48(4):1077–1083. [PubMed] [Google Scholar]
  4. BERNHARD W. Electron microscopy of tumor cells and tumor viruses; a review. Cancer Res. 1958 Jun;18(5):491–509. [PubMed] [Google Scholar]
  5. BERNHARD W., GUERIN M. Presence de particules d'aspect virusal dans les tissus tumoraux de souris atteintes de leucémie spontanée. C R Hebd Seances Acad Sci. 1958 Nov 17;247(20):1802–1805. [PubMed] [Google Scholar]
  6. BERNHARD W. The detection and study of tumor viruses with the electron microscope. Cancer Res. 1960 Jun;20:712–727. [PubMed] [Google Scholar]
  7. Baltimore D. RNA-dependent DNA polymerase in virions of RNA tumour viruses. Nature. 1970 Jun 27;226(5252):1209–1211. doi: 10.1038/2261209a0. [DOI] [PubMed] [Google Scholar]
  8. Bernhard W., Viron A. Improved techniques for the preparation of ultrathin frozen sections. J Cell Biol. 1971 Jun;49(3):731–746. doi: 10.1083/jcb.49.3.731. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Bhisey A. N., Freed J. J. Ameboid movement induced in cultured macrophages by colchicine or vinblastine. Exp Cell Res. 1971 Feb;64(2):419–429. doi: 10.1016/0014-4827(71)90096-6. [DOI] [PubMed] [Google Scholar]
  10. CRUICKSHANK C. N., HARCOURT S. A. PIGMENT DONATION IN VITRO. J Invest Dermatol. 1964 Feb;42:183–184. doi: 10.1038/jid.1964.39. [DOI] [PubMed] [Google Scholar]
  11. Carter S. B. Effects of cytochalasins on mammalian cells. Nature. 1967 Jan 21;213(5073):261–264. doi: 10.1038/213261a0. [DOI] [PubMed] [Google Scholar]
  12. Christensen A. K. Frozen thin sections of fresh tissue for electron microscopy, with a description of pancreas and liver. J Cell Biol. 1971 Dec;51(3):772–804. doi: 10.1083/jcb.51.3.772. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Cohen J., Szabó G. Study of pigment donation in vitro. Exp Cell Res. 1968 May;50(2):418–433. doi: 10.1016/0014-4827(68)90460-6. [DOI] [PubMed] [Google Scholar]
  14. Césarini J. P., de Micco C. Studies on type-H virus-like particles in hamster: their role in oncogenesis. Int J Cancer. 1972 Jul 15;10(1):174–185. doi: 10.1002/ijc.2910100123. [DOI] [PubMed] [Google Scholar]
  15. DALTON A. J., FELIX M. D. The electron microscopy of normal and malignant cells. Ann N Y Acad Sci. 1956 Mar 30;63(6):1117–1140. doi: 10.1111/j.1749-6632.1956.tb32127.x. [DOI] [PubMed] [Google Scholar]
  16. DALTON A. J. Organization in benign and malignant cells. Lab Invest. 1959 Mar-Apr;8(2):510–537. [PubMed] [Google Scholar]
  17. DROCHMANS P. MELANIN GRANULES: THEIR FINE STRUCTURE, FORMATION, AND DEGRADATION IN NORMAL AND PATHOLOGICAL TISSUES. Int Rev Exp Pathol. 1963;2:357–422. [PubMed] [Google Scholar]
  18. Dalton A. J. Further analysis of the detailed structure of type B and C particles. J Natl Cancer Inst. 1972 Apr;48(4):1095–1099. [PubMed] [Google Scholar]
  19. Dalton A. J. Observations on the details of ultrastructure of a series of type c viruses. Cancer Res. 1972 Jun;32(6):1351–1353. [PubMed] [Google Scholar]
  20. Dalton A. J. RNA tumor viruses. Terminology and ultrastructural aspects of virion morphology and replication. J Natl Cancer Inst. 1972 Aug;49(2):323–327. [PubMed] [Google Scholar]
  21. Daniels M. P. Colchicine inhibition of nerve fiber formation in vitro. J Cell Biol. 1972 Apr;53(1):164–176. doi: 10.1083/jcb.53.1.164. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Eppig J. J., Jr, Dumont J. N. Cytochemical localization of tyrosinase activity in pigmented epithelial cells of Rana pipiens and Xenopus laevis larvae. J Ultrastruct Res. 1972 May;39(3):397–410. doi: 10.1016/s0022-5320(72)90031-7. [DOI] [PubMed] [Google Scholar]
  23. Epstein W. L., Fukuyama K., Benn M., Keston A. S., Brandt R. B. Transmission of a pigmented melanoma in golden hamsters by a cell-free ultrafiltrate. Nature. 1968 Aug 31;219(5157):979–980. doi: 10.1038/219979a0. [DOI] [PubMed] [Google Scholar]
  24. Epstein W. L., Fukuyama K., Drake T. E. Ultrastructural effects of thymidine analogs in melanosomes and virus activation in cloned hamster melanoma cells in culture. Yale J Biol Med. 1973 Dec;46(5):471–481. [PMC free article] [PubMed] [Google Scholar]
  25. Epstein W. L., Fukuyama K. Light and electron microscopic studies of a transplantable melanoma associated with virus-like particles. Cancer Res. 1970 May;30(5):1241–1247. [PubMed] [Google Scholar]
  26. Franke W. W. Relationship of nuclear membranes with filaments and microtubules. Protoplasma. 1971;73(2):263–292. doi: 10.1007/BF01275600. [DOI] [PubMed] [Google Scholar]
  27. Fujii R., Novales R. R. Cellular aspects of the control of physiological color changes in fishes. Am Zool. 1969 May;9(2):453–463. doi: 10.1093/icb/9.2.453. [DOI] [PubMed] [Google Scholar]
  28. Furmanski P., Silverman D. J., Lubin M. Expression of differentiated functions in mouse neuroblastoma mediated by dibutyryl-cyclic adenosine monophosphate. Nature. 1971 Oct 8;233(5319):413–415. doi: 10.1038/233413a0. [DOI] [PubMed] [Google Scholar]
  29. GREENE H. S. A spontaneous melanoma in the hamster with a propensity for amelanotic alteration and sarcomatous transformation during transplantation. Cancer Res. 1958 May;18(4):422–425. [PubMed] [Google Scholar]
  30. Goldman R. D. The role of three cytoplasmic fibers in BHK-21 cell motility. I. Microtubules and the effects of colchicine. J Cell Biol. 1971 Dec;51(3):752–762. doi: 10.1083/jcb.51.3.752. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Green L. MECHANISM OF MOVEMENTS OF GRANULES IN MELANOCYTES OF Fundulus heteroclitus. Proc Natl Acad Sci U S A. 1968 Apr;59(4):1179–1186. doi: 10.1073/pnas.59.4.1179. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Hansson H. A., Norström A. Glial reactions induced by colchicine-treatment of the hypothalamic-neurohypophyseal system. Z Zellforsch Mikrosk Anat. 1971;113(2):294–310. doi: 10.1007/BF00339422. [DOI] [PubMed] [Google Scholar]
  33. Haran-Ghera N., Peled A. The mechanism of radiation action in leukaemogenesis. Isolation of a leukaemogenic filtrable agent from tissues of irradiated and normal C57BL mice. Br J Cancer. 1967 Dec;21(4):730–738. doi: 10.1038/bjc.1967.85. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Hearing V. J., Lutzner M. A. Mammalian melanosomal proteins: characterization by polyacrylamide gel electrophoresis. Yale J Biol Med. 1973 Dec;46(5):553–559. [PMC free article] [PubMed] [Google Scholar]
  35. Heckman C. A., Barrnett R. J. GACH: a water-miscible, lipid-retaining embedding polymer for electron microscopy. J Ultrastruct Res. 1973 Jan;42(1):156–179. doi: 10.1016/s0022-5320(73)80013-9. [DOI] [PubMed] [Google Scholar]
  36. Higgins J. A., Barrnett R. J. STUDIES ON THE BIOGENESIS OF SMOOTH ENDOPLASMIC RETICULUM MEMBRANES IN LIVERS OF PHENOBARBITAL-TREATED RATS : I. The Site of Activity of Acyltransferases Involved in Synthesis of the Membrane Phospholipid. J Cell Biol. 1972 Nov 1;55(2):282–298. doi: 10.1083/jcb.55.2.282. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Huebner R. J., Todaro G. J. Oncogenes of RNA tumor viruses as determinants of cancer. Proc Natl Acad Sci U S A. 1969 Nov;64(3):1087–1094. doi: 10.1073/pnas.64.3.1087. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. Hunter J. A., Mottaz J. H., Zelickson A. S. Melanogenesis: ultrastructural histochemical observations on ultraviolet irradiated human melanocytes. J Invest Dermatol. 1970 Mar;54(3):213–221. doi: 10.1111/1523-1747.ep12280277. [DOI] [PubMed] [Google Scholar]
  39. Ishikawa H., Bischoff R., Holtzer H. Formation of arrowhead complexes with heavy meromyosin in a variety of cell types. J Cell Biol. 1969 Nov;43(2):312–328. [PMC free article] [PubMed] [Google Scholar]
  40. Ishikawa H., Bischoff R., Holtzer H. Mitosis and intermediate-sized filaments in developing skeletal muscle. J Cell Biol. 1968 Sep;38(3):538–555. doi: 10.1083/jcb.38.3.538. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. Ito R., Mishima Y. Particles in the cisternae of the endoplasmic reticulum of Fortner's amelanotic and melanotic malignant melanomas. J Invest Dermatol. 1967 Mar;48(3):268–272. doi: 10.1038/jid.1967.45. [DOI] [PubMed] [Google Scholar]
  42. Jande S. S. Fine structure of tadpole melanophores. Anat Rec. 1966 Mar;154(3):533–543. doi: 10.1002/ar.1091540304. [DOI] [PubMed] [Google Scholar]
  43. KINOSITA H. Electrophoretic theory of pigment migration within fish melanophore. Ann N Y Acad Sci. 1963 Feb 15;100:992–1004. [PubMed] [Google Scholar]
  44. Klaus S. N. Pigment transfer in mammalian epidermis. Arch Dermatol. 1969 Dec;100(6):756–762. [PubMed] [Google Scholar]
  45. Klingmuller G., Schmoeckel C. Frei im Cytoplasma liegende Melanin-synthetisierende Membrananordnungen beim malignen Melanom. Arch Dermatol Forsch. 1971;241(2):115–121. [PubMed] [Google Scholar]
  46. Krishan A., Hsu D. Binding of colchicine-3H to vinblastine- and vincristine-induced crystals in mammalian tissue culture cells. J Cell Biol. 1971 Feb;48(2):407–410. doi: 10.1083/jcb.48.2.407. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. Ledbetter M. C., Porter K. R. A "MICROTUBULE" IN PLANT CELL FINE STRUCTURE. J Cell Biol. 1963 Oct 1;19(1):239–250. doi: 10.1083/jcb.19.1.239. [DOI] [PMC free article] [PubMed] [Google Scholar]
  48. Leduc E. H., Bernhard W. Recent modifications of the glycol methacrylate embedding procedure. J Ultrastruct Res. 1967 Jul;19(1):196–199. doi: 10.1016/s0022-5320(67)80068-6. [DOI] [PubMed] [Google Scholar]
  49. Lyerla T. A., Novales R. R. Effect of cyclic AMP and cytochalasin B on tissue cultured melanophores of Xenopus laevis. J Cell Physiol. 1972 Oct;80(2):243–251. doi: 10.1002/jcp.1040800211. [DOI] [PubMed] [Google Scholar]
  50. MALAWISTA S. E. ON THE ACTION OF COLCHICINE, THE MELANOCYTE MODEL. J Exp Med. 1965 Aug 1;122:361–384. doi: 10.1084/jem.122.2.361. [DOI] [PMC free article] [PubMed] [Google Scholar]
  51. MISHIMA Y. ELECTRON MICROSCOPIC CYTOCHEMISTRY OF MELANOSOMES AND MITOCHONDRIA. J Histochem Cytochem. 1964 Oct;12:784–790. doi: 10.1177/12.10.784. [DOI] [PubMed] [Google Scholar]
  52. Malawista S. E. Cytochalasin B reversibly inhibits melanin granule movement in melanocytes. Nature. 1971 Dec 10;234(5328):354–355. doi: 10.1038/234354a0. [DOI] [PubMed] [Google Scholar]
  53. Malawista S. E. The melanocyte model. Colchicine-like effects of other antimitotic agents. J Cell Biol. 1971 Jun;49(3):848–855. doi: 10.1083/jcb.49.3.848. [DOI] [PMC free article] [PubMed] [Google Scholar]
  54. Marantz R., Shelanski M. L. Structure of microtubular crystals induced by vinblastine in vitro. J Cell Biol. 1970 Jan;44(1):234–238. doi: 10.1083/jcb.44.1.234. [DOI] [PMC free article] [PubMed] [Google Scholar]
  55. Maul G. G. Golgi-melanosome relationship in human melanoma in vitro. J Ultrastruct Res. 1969 Jan;26(1):163–176. doi: 10.1016/s0022-5320(69)90042-2. [DOI] [PubMed] [Google Scholar]
  56. McGuire J., Moellmann G. Cytochalasin B: effects on microfilaments and movement of melanin granules within melanocytes. Science. 1972 Feb 11;175(4022):642–644. doi: 10.1126/science.175.4022.642. [DOI] [PubMed] [Google Scholar]
  57. McGuire J., Moellmann G., McKeon F. Cytochalasin B and pigment granule translocation. Cytochalasin B reverses and prevents pigment granule dispersion caused by dibutyryl cyclic AMP and theophylline in Rana pipiens Melanocytes. J Cell Biol. 1972 Mar;52(3):754–758. doi: 10.1083/jcb.52.3.754. [DOI] [PMC free article] [PubMed] [Google Scholar]
  58. Mottaz J. H., Zelickson A. S. Melanin transfer: a possible phagocytic process. J Invest Dermatol. 1967 Dec;49(6):605–610. doi: 10.1038/jid.1967.187. [DOI] [PubMed] [Google Scholar]
  59. Möller H., Lerner A. B. Melanocyte stimulating hormone inhibition by acetylcholine and noradrenaline in the frog skin bioassay. Acta Endocrinol (Copenh) 1966 Jan;51(1):149–160. doi: 10.1530/acta.0.0510149. [DOI] [PubMed] [Google Scholar]
  60. Novikoff A. B., Albala A., Biempica L. Ultrastructural and cytochemical observations on B-16 and Harding-Passey mouse melanomas. The origin of premelanosomes and compound melanosomes. J Histochem Cytochem. 1968 May;16(5):299–319. doi: 10.1177/16.5.299. [DOI] [PubMed] [Google Scholar]
  61. Ochs S. Characteristics and a model for fast axoplasmic transport in nerve. J Neurobiol. 1971;2(4):331–345. doi: 10.1002/neu.480020406. [DOI] [PubMed] [Google Scholar]
  62. Ochs S., Ranish N. Characteristics of the fast transport system in mammalian nerve fibers. J Neurobiol. 1969;1(2):247–261. doi: 10.1002/neu.480010211. [DOI] [PubMed] [Google Scholar]
  63. Olmsted J. B., Carlson K., Klebe R., Ruddle F., Rosenbaum J. Isolation of microtubule protein from cultured mouse neuroblastoma cells. Proc Natl Acad Sci U S A. 1970 Jan;65(1):129–136. doi: 10.1073/pnas.65.1.129. [DOI] [PMC free article] [PubMed] [Google Scholar]
  64. Pawelek J., Wong G., Sansone M., Morowitz J. Molecular biology of pigment cells. Molecular controls in mammalian pigmentation. Yale J Biol Med. 1973 Dec;46(5):430–443. [PMC free article] [PubMed] [Google Scholar]
  65. Pease D. C., Peterson R. G. Polymerizable glutaraldehyde-urea mixtures as polar, water-containing embedding media. J Ultrastruct Res. 1972 Oct;41(1):133–159. doi: 10.1016/s0022-5320(72)90043-3. [DOI] [PubMed] [Google Scholar]
  66. Peters A., Vaughn J. E. Microtubules and filaments in the axons and astrocytes of early postnatal rat optic nerves. J Cell Biol. 1967 Jan;32(1):113–119. doi: 10.1083/jcb.32.1.113. [DOI] [PMC free article] [PubMed] [Google Scholar]
  67. Peterson R. G., Pease D. C. Myelin embedded in polymerized glutaraldehyde-urea. J Ultrastruct Res. 1972 Oct;41(1):115–132. doi: 10.1016/s0022-5320(72)90042-1. [DOI] [PubMed] [Google Scholar]
  68. Prasad K. N., Hsie A. W. Morphologic differentiation of mouse neuroblastoma cells induced in vitro by dibutyryl adenosine 3':5'-cyclic monophosphate. Nat New Biol. 1971 Sep 29;233(39):141–142. doi: 10.1038/newbio233141a0. [DOI] [PubMed] [Google Scholar]
  69. Prasad K. N., Sheppard J. R. Inhibitors of cyclic-nucleotide phosphodiesterase induce morphological differentiation of mouse neuroblastoma cell culture. Exp Cell Res. 1972 Aug;73(2):436–440. doi: 10.1016/0014-4827(72)90069-9. [DOI] [PubMed] [Google Scholar]
  70. ROBBINS E., GONATAS N. K. HISTOCHEMICAL AND ULTRASTRUCTURAL STUDIES ON HELA CELL CULTURES EXPOSED TO SPINDLE INHIBITORS WITH SPECIAL REFERENCE TO THE INTERPHASE CELL. J Histochem Cytochem. 1964 Sep;12:704–711. doi: 10.1177/12.9.704. [DOI] [PubMed] [Google Scholar]
  71. Rebhun L. I. Structural aspects of saltatory particle movement. J Gen Physiol. 1967 Jul;50(6 Suppl):223–239. doi: 10.1085/jgp.50.6.223. [DOI] [PMC free article] [PubMed] [Google Scholar]
  72. Rodriguez H. A., Mcgavran M. H. A modified DOPA reaction for the diagnosis and investigation of pigment cells. Am J Clin Pathol. 1969 Aug;52(2):219–227. doi: 10.1093/ajcp/52.2.219. [DOI] [PubMed] [Google Scholar]
  73. Ruprecht K. W. Pigmentierung der Dunenfeder von Gallus domesticus L. Licht- und elektronenmikroskopische Untersuchungen zur Melanosomenübertragung. Z Zellforsch Mikrosk Anat. 1971;112(3):396–413. [PubMed] [Google Scholar]
  74. SEIJI M., SHIMAO K., BIRBECK M. S., FITZPATRICK T. B. Subcellular localization of melanin biosynthesis. Ann N Y Acad Sci. 1963 Feb 15;100:497–533. [PubMed] [Google Scholar]
  75. Schlaepfer W. W. Stabilization of neurofilaments by vincristine sulfate in low ionic strength media. J Ultrastruct Res. 1971 Aug;36(3):367–374. doi: 10.1016/s0022-5320(71)80110-7. [DOI] [PubMed] [Google Scholar]
  76. Schlaepfer W. W. Vincristine-induced axonal alterations in rat peripheral nerve. J Neuropathol Exp Neurol. 1971 Jul;30(3):488–505. doi: 10.1097/00005072-197107000-00012. [DOI] [PubMed] [Google Scholar]
  77. Schubert D., Humphreys S., Baroni C., Cohn M. In vitro differentiation of a mouse neuroblastoma. Proc Natl Acad Sci U S A. 1969 Sep;64(1):316–323. doi: 10.1073/pnas.64.1.316. [DOI] [PMC free article] [PubMed] [Google Scholar]
  78. Shelanski M. L., Taylor E. W. Isolation of a protein subunit from microtubules. J Cell Biol. 1967 Aug;34(2):549–554. doi: 10.1083/jcb.34.2.549. [DOI] [PMC free article] [PubMed] [Google Scholar]
  79. Shipman C., Jr, Vander Weide G. C., Ma B. I. Prevalence of type R virus-like particles in clones of BHK-21 cells. Virology. 1969 Aug;38(4):707–710. doi: 10.1016/0042-6822(69)90192-5. [DOI] [PubMed] [Google Scholar]
  80. Somlyo A. P., Somlyo A. V., Devine C. E., Rice R. V. Aggregation of thick filaments into ribbons in mammalian smooth muscle. Nat New Biol. 1971 Jun 23;231(25):243–246. doi: 10.1038/newbio231243a0. [DOI] [PubMed] [Google Scholar]
  81. Stanka P. Elektronemikroskopische Untersuchung über die Prämelanosemenentstehung im retinalen Pigmentepithel von Hühnerembryonen. Z Zellforsch Mikrosk Anat. 1971;112(1):120–128. [PubMed] [Google Scholar]
  82. Szabó G., Gerald A. B., Pathak M. A., Fitzpatrick T. B. Racial differences in the fate of melanosomes in human epidermis. Nature. 1969 Jun 14;222(5198):1081–1082. doi: 10.1038/2221081a0. [DOI] [PubMed] [Google Scholar]
  83. THOMAS J. A. RELATIONS ULTRASTRUCTURALES D'UN VIRUS ET DU CHONDRIOME: COMPARAISON DE L''EVOLUTION VIRALE DANS LES CELLULES BHK 21-13, DANS LES CELLULES CANC'EREUSES INDUITES PAR CELLES-CI ET DANS LES CELLULES H 54. C R Hebd Seances Acad Sci. 1964 Jun 15;258:6018–6021. [PubMed] [Google Scholar]
  84. Takahashi M., Mishima Y. A sequence of virus-like particle formation in the ergastoplasm of Greene's malignant melanoma cells. Cancer. 1969 Nov;24(5):904–911. doi: 10.1002/1097-0142(196911)24:5<904::aid-cncr2820240507>3.0.co;2-j. [DOI] [PubMed] [Google Scholar]
  85. Temin H. M. Mechanism of cell transformation by RNA tumor viruses. Annu Rev Microbiol. 1971;25:609–648. doi: 10.1146/annurev.mi.25.100171.003141. [DOI] [PubMed] [Google Scholar]
  86. Temin H. M., Mizutani S. RNA-dependent DNA polymerase in virions of Rous sarcoma virus. Nature. 1970 Jun 27;226(5252):1211–1213. doi: 10.1038/2261211a0. [DOI] [PubMed] [Google Scholar]
  87. Thomas J. A., Delain E., Hollande E. Morphogenèse d'un virus du hamster associé à la souche BHK, ou à des tumeurs. C R Acad Sci Hebd Seances Acad Sci D. 1967 Jan 30;264(5):785–788. [PubMed] [Google Scholar]
  88. Tilney L. G. Studies on the microtubules in heliozoa. IV. The effect of colchicine on the formation and maintenance of the axopodia and the redevelopment of pattern in Actinosphaerium nucleofilum (Barrett). J Cell Sci. 1968 Dec;3(4):549–562. doi: 10.1242/jcs.3.4.549. [DOI] [PubMed] [Google Scholar]
  89. Toda K., Pathak M. A., Parrish J. A., Fitzpatrick T. B., Quevedo W. C., Jr Alteration of racial differences in melanosome distribution in human epidermis after exposure to ultraviolet light. Nat New Biol. 1972 Apr 5;236(66):143–145. doi: 10.1038/newbio236143a0. [DOI] [PubMed] [Google Scholar]
  90. Todaro G. J., Huebner R. J. N.A.S. symposium: new evidence as the basis for increased efforts in cancer research. Proc Natl Acad Sci U S A. 1972 Apr;69(4):1009–1015. doi: 10.1073/pnas.69.4.1009. [DOI] [PMC free article] [PubMed] [Google Scholar]
  91. WEISS P., HISCOE H. B. Experiments on the mechanism of nerve growth. J Exp Zool. 1948 Apr;107(3):315–395. doi: 10.1002/jez.1401070302. [DOI] [PubMed] [Google Scholar]
  92. WELLINGS S. R., SIEGEL B. V. Electron microscopic studies on the subcellular origin and ultrastructure of melanin granules in mammalian melanomas. Ann N Y Acad Sci. 1963 Feb 15;100:548–568. doi: 10.1111/j.1749-6632.1963.tb42914.x. [DOI] [PubMed] [Google Scholar]
  93. Weisenberg R. C., Borisy G. G., Taylor E. W. The colchicine-binding protein of mammalian brain and its relation to microtubules. Biochemistry. 1968 Dec;7(12):4466–4479. doi: 10.1021/bi00852a043. [DOI] [PubMed] [Google Scholar]
  94. Werner I. Control of pigment synthesis in culture. Yale J Biol Med. 1973 Dec;46(5):444–463. [PMC free article] [PubMed] [Google Scholar]
  95. Wessells N. K., Spooner B. S., Ash J. F., Bradley M. O., Luduena M. A., Taylor E. L., Wrenn J. T., Yamada K. Microfilaments in cellular and developmental processes. Science. 1971 Jan 15;171(3967):135–143. doi: 10.1126/science.171.3967.135. [DOI] [PubMed] [Google Scholar]
  96. Wikswo M. A. Action of cyclic AMP on pigment donation between mammalian melanocytes and keratinocytes. Yale J Biol Med. 1973 Dec;46(5):592–601. [PMC free article] [PubMed] [Google Scholar]
  97. Wikswo M. A., Novales R. R. Effect of colchicine on microtubules in the melanophores of Fundulus heteroclitus. J Ultrastruct Res. 1972 Nov;41(3):189–201. doi: 10.1016/s0022-5320(72)90063-9. [DOI] [PubMed] [Google Scholar]
  98. Wikswo M. A., Novales R. R. The effect of colchicine on migration of pigment granules in the melanophores of Fundulus heteroclitus. Biol Bull. 1969 Aug;137(1):228–237. doi: 10.2307/1539945. [DOI] [PubMed] [Google Scholar]
  99. Wikswo M. A., Szabo G. Effects of cytochalasin B on mammalian melanocytes and keratinocytes. J Invest Dermatol. 1972 Aug;59(2):163–169. doi: 10.1111/1523-1747.ep12625950. [DOI] [PubMed] [Google Scholar]
  100. Wise G. E. Ultrastructure of amphibian melanophores after light-dark adaptation and hormonal treatment. J Ultrastruct Res. 1969 Jun;27(5):472–485. doi: 10.1016/s0022-5320(69)80045-6. [DOI] [PubMed] [Google Scholar]
  101. Wisniewski H., Shelanski M. L., Terry R. D. Effects of mitotic spindle inhibitors on neurotubules and neurofilaments in anterior horn cells. J Cell Biol. 1968 Jul;38(1):224–229. doi: 10.1083/jcb.38.1.224. [DOI] [PMC free article] [PubMed] [Google Scholar]
  102. Wiśniewski H., Terry R. D., Hirano A. Neurofibrillary pathology. J Neuropathol Exp Neurol. 1970 Apr;29(2):163–176. [PubMed] [Google Scholar]
  103. Wolff K., Konrad K. Melanin pigmentation: an in vivo model for studies of melanosome kinetics within keratinocytes. Science. 1971 Dec 3;174(4013):1034–1035. doi: 10.1126/science.174.4013.1034. [DOI] [PubMed] [Google Scholar]
  104. Wolff K., Konrad K. Phagocytosis of latex beads by epidermal keratinocytes in vivo. J Ultrastruct Res. 1972 May;39(3):262–280. doi: 10.1016/s0022-5320(72)90022-6. [DOI] [PubMed] [Google Scholar]
  105. Wolff K. Melanocyte-keratinocyte interactions in vivo: the fate of melanosomes. Yale J Biol Med. 1973 Dec;46(5):384–396. [PMC free article] [PubMed] [Google Scholar]
  106. Wong G., Pawelek J. Control of phenotypic expression of cultured melanoma cells by melanocyte stimulating hormones. Nat New Biol. 1973 Feb 14;241(111):213–215. doi: 10.1038/newbio241213a0. [DOI] [PubMed] [Google Scholar]
  107. Yamada K. M., Spooner B. S., Wessells N. K. Axon growth: roles of microfilaments and microtubules. Proc Natl Acad Sci U S A. 1970 Aug;66(4):1206–1212. doi: 10.1073/pnas.66.4.1206. [DOI] [PMC free article] [PubMed] [Google Scholar]
  108. Yamada K. M., Spooner B. S., Wessells N. K. Ultrastructure and function of growth cones and axons of cultured nerve cells. J Cell Biol. 1971 Jun;49(3):614–635. doi: 10.1083/jcb.49.3.614. [DOI] [PMC free article] [PubMed] [Google Scholar]
  109. ZELICKSON A. S., HIRSCH H. M., HARTMANN J. F. MELANOGENESIS: AN AUTORADIOGRAPHIC STUDY AT THE ULTRASTRUCTURAL LEVEL. J Invest Dermatol. 1964 Nov;43:327–332. [PubMed] [Google Scholar]

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