Abstract
Antibodies to the mitotic spindle apparatus (MS) have been detected in only a very few patient sera studied for antinuclear antibodies by routine screening (G. A. McCarty, D. W. Velencia, and M. J. Fritzler, J. Rheumatol. 11:213-218, 1984). We found anti-MS antibodies to be quite common in sera from patients with Mycoplasma pneumoniae, especially in those who developed cold agglutinins (71%). Absorption experiments indicated that the formation of anti-MS antibodies is not triggered by epitopes on the M. pneumoniae surface. These antibodies were distinct from cold agglutinins, antibrain antibodies, and smooth-muscle antibodies. All patients previously reported to harbor anti-MS had clinical features compatible with a diagnosis of systemic lupus erythematosus, rheumatoid arthritis, or an evolving connective-tissue disorder. Such systemic disorders might develop in a small proportion of patients who have had M. pneumoniae illness.
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- Biberfeld G., Sterner G. Smooth muscle antibodies in Mycoplasma pneumoniae infection. Clin Exp Immunol. 1976 May;24(2):287–291. [PMC free article] [PubMed] [Google Scholar]
- Bretherton L., Toh B. H., Jack I. IgM autoantibody to intermediate filaments in Mycoplasma pneumoniae infections. Clin Immunol Immunopathol. 1981 Mar;18(3):425–430. doi: 10.1016/0090-1229(81)90135-5. [DOI] [PubMed] [Google Scholar]
- Lind K. Manifestations and complications of Mycoplasma pneumoniae disease: a review. Yale J Biol Med. 1983 Sep-Dec;56(5-6):461–468. [PMC free article] [PubMed] [Google Scholar]
- McCarty G. A., Valencia D. W., Fritzler M. J. Antibody to the mitotic spindle apparatus: immunologic characteristics and cytologic studies. J Rheumatol. 1984 Apr;11(2):213–218. [PubMed] [Google Scholar]
- Mizutani H., Mizutani H. Immunoglobulin M rheumatoid factor in patients with mycoplasmal pneumonia. Am Rev Respir Dis. 1986 Dec;134(6):1237–1240. doi: 10.1164/arrd.1986.134.6.1237. [DOI] [PubMed] [Google Scholar]
- Neimark H. C. Extraction of an actin-like protein from the prokaryote Mycoplasma pneumoniae. Proc Natl Acad Sci U S A. 1977 Sep;74(9):4041–4045. doi: 10.1073/pnas.74.9.4041. [DOI] [PMC free article] [PubMed] [Google Scholar]