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. 2001 Mar;93(3):104–108.

Lead levels in the milk of Fulani women in Nigeria.

D J VanderJagt 1, S N Okolo 1, L Romero 1, M Millson 1, R H Glew 1
PMCID: PMC2593945  PMID: 12656442

Abstract

Levels of lead were determined in the milk of 34 Fulani women in Plateau State in northern Nigeria. The Fulani are nomadic, semi-pastoralists who inhabit the western Sahel, including the countries of Mali, Burkino Faso, the Republic of Niger, Nigeria and Chad. The mean age of the women in this study was 26.0 +/- 7.5 years and their mean body mass index (BMI, kg/m2) was 19.4 (range, 14.5-24.0). Their average parity was 4 (range, 1-10). Milk was collected 2-24 weeks postgestation (mean, 11 weeks). Fifteen of the 34 milk specimens contained measurable lead (limit of detection, 4.6 microg/dL); the milk of the other 19 women (56%) did not contain a detectable level of lead. The data were not normally distributed. The median lead concentration of all 34 milk specimens, determined by end on plasma-axial view spectrometry, was 6.7 microg/dL (range, < 4.6-130 microg/dL). Given the mean weight of the 34 infants in the study (4.6 kg) and assuming that each infant consumed 0.7 L/day of milk, the average lead intake of these exclusively breastfed infants was 9.9 microg/kg/day, a value which is twice the daily permissible intake (DPI) of 5.0 microg/g/day set by the World Health Organization in 1972. These data indicate that some exclusively breastfed Fulani infants in the Jos Plateau are at risk of injury from lead derived from their mothers' milk, and raise questions about the actual blood levels in these nursing infants and the source(s) of the maternal lead.

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Selected References

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  1. Chatranon W., Chavalittamrong B., Kritalugsana S., Pringsulaka P. Lead concentrations in breast milk at various stages of lactation. Southeast Asian J Trop Med Public Health. 1978 Sep;9(3):420–422. [PubMed] [Google Scholar]
  2. Freiberger C. E., Vanderjagt D. J., Pastuszyn A., Glew R. S., Mounkaila G., Millson M., Glew R. H. Nutrient content of the edible leaves of seven wild plants from Niger. Plant Foods Hum Nutr. 1998;53(1):57–69. doi: 10.1023/a:1008080508028. [DOI] [PubMed] [Google Scholar]
  3. Gross S. B., Pfitzer E. A., Yeager D. W., Kehoe R. A. Lead in human tissues. Toxicol Appl Pharmacol. 1975 Jun;32(3):638–651. doi: 10.1016/0041-008x(75)90127-1. [DOI] [PubMed] [Google Scholar]
  4. Gulson B. L., Jameson C. W., Mahaffey K. R., Mizon K. J., Korsch M. J., Vimpani G. Pregnancy increases mobilization of lead from maternal skeleton. J Lab Clin Med. 1997 Jul;130(1):51–62. doi: 10.1016/s0022-2143(97)90058-5. [DOI] [PubMed] [Google Scholar]
  5. Gulson B. L., Jameson C. W., Mahaffey K. R., Mizon K. J., Patison N., Law A. J., Korsch M. J., Salter M. A. Relationships of lead in breast milk to lead in blood, urine, and diet of the infant and mother. Environ Health Perspect. 1998 Oct;106(10):667–674. doi: 10.1289/ehp.98106667. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hallén I. P., Jorhem L., Lagerkvist B. J., Oskarsson A. Lead and cadmium levels in human milk and blood. Sci Total Environ. 1995 Apr 21;166:149–155. doi: 10.1016/0048-9697(95)04523-4. [DOI] [PubMed] [Google Scholar]
  7. Huat L. H., Zakariya D., Eng K. H. Lead concentrations in breast milk of Malaysian urban and rural mothers. Arch Environ Health. 1983 Jul-Aug;38(4):205–209. doi: 10.1080/00039896.1983.10545803. [DOI] [PubMed] [Google Scholar]
  8. Keller C. A., Doherty R. A. Bone lead mobilization in lactating mice and lead transfer to suckling offspring. Toxicol Appl Pharmacol. 1980 Sep 15;55(2):220–228. doi: 10.1016/0041-008x(80)90083-6. [DOI] [PubMed] [Google Scholar]
  9. Kovar I. Z., Strehlow C. D., Richmond J., Thompson M. G. Perinatal lead and cadmium burden in a British urban population. Arch Dis Child. 1984 Jan;59(1):36–39. doi: 10.1136/adc.59.1.36. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Larsson B., Slorach S. A., Hagman U., Hofvander Y. WHO collaborative breast feeding study. II. Levels of lead and cadmium in Swedish human milk, 1978-1979. Acta Paediatr Scand. 1981;70(3):281–284. doi: 10.1111/j.1651-2227.1981.tb16552.x. [DOI] [PubMed] [Google Scholar]
  11. Namihira D., Saldivar L., Pustilnik N., Carreón G. J., Salinas M. E. Lead in human blood and milk from nursing women living near a smelter in Mexico City. J Toxicol Environ Health. 1993 Mar;38(3):225–232. doi: 10.1080/15287399309531714. [DOI] [PubMed] [Google Scholar]
  12. Needleman H. L., Schell A., Bellinger D., Leviton A., Allred E. N. The long-term effects of exposure to low doses of lead in childhood. An 11-year follow-up report. N Engl J Med. 1990 Jan 11;322(2):83–88. doi: 10.1056/NEJM199001113220203. [DOI] [PubMed] [Google Scholar]
  13. Okolo S. N., VanderJagt T. J., Vu T., VanderJagt T. A., VanderJagt D. J., Okonji M., Huang Y. S., Chuang L. T., Onwuanaku C., Glew R. H. The fatty acid composition of human milk in northern Nigeria. J Hum Lact. 2000 Feb;16(1):28–35. doi: 10.1177/089033440001600106. [DOI] [PubMed] [Google Scholar]
  14. Ong C. N., Phoon W. O., Law H. Y., Tye C. Y., Lim H. H. Concentrations of lead in maternal blood, cord blood, and breast milk. Arch Dis Child. 1985 Aug;60(8):756–759. doi: 10.1136/adc.60.8.756. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Rabinowitz M. B., Kopple J. D., Wetherill G. W. Effect of food intake and fasting on gastrointestinal lead absorption in humans. Am J Clin Nutr. 1980 Aug;33(8):1784–1788. doi: 10.1093/ajcn/33.8.1784. [DOI] [PubMed] [Google Scholar]
  16. Rabinowitz M. B., Wetherill G. W., Kopple J. D. Kinetic analysis of lead metabolism in healthy humans. J Clin Invest. 1976 Aug;58(2):260–270. doi: 10.1172/JCI108467. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Rabinowitz M., Leviton A., Needleman H. Lead in milk and infant blood: a dose-response model. Arch Environ Health. 1985 Sep-Oct;40(5):283–286. doi: 10.1080/00039896.1985.10545933. [DOI] [PubMed] [Google Scholar]
  18. Saleh M. A., Ragab A. A., Kamel A., Jones J., el-Sebae A. K. Regional distribution of lead in human milk from Egypt. Chemosphere. 1996 May;32(9):1859–1867. doi: 10.1016/0045-6535(96)00079-3. [DOI] [PubMed] [Google Scholar]
  19. Schmeits B. L., Okolo S. N., VanderJagt D. J., Huang Y. S., Chuang L. T., Mata J. R., Tsin A. A., Glew R. H. Content of lipid nutrients in the milk of Fulani women. J Hum Lact. 1999 Jun;15(2):113–120. doi: 10.1177/089033449901500208. [DOI] [PubMed] [Google Scholar]
  20. Thacher T., Glew R. H., Isichei C., Lawson J. O., Scariano J. K., Hollis B. W., VanderJagt D. J. Rickets in Nigerian children: response to calcium supplementation. J Trop Pediatr. 1999 Aug;45(4):202–207. doi: 10.1093/tropej/45.4.202. [DOI] [PubMed] [Google Scholar]
  21. Tóth E., Benkóné V. Z., Oroszlán G., Ulveczky E. Perinatalis vér-ólomszint fokozott ólomexpozíciójú városban. Orv Hetil. 1989 Dec 10;130(50):2679–2681. [PubMed] [Google Scholar]
  22. Walter E. A., Scariano J. K., Easington C. R., Polaco A. M., Hollis B. W., Dasgupta A., Pam S., Glew R. H. Rickets and protein malnutrition in northern Nigeria. J Trop Pediatr. 1997 Apr;43(2):98–102. doi: 10.1093/tropej/43.2.98. [DOI] [PubMed] [Google Scholar]

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