Skip to main content
NCBI home page
Journal of the National Medical Association logoLink to Journal of the National Medical Association
. 2001 Apr;93(4):113–119.

Abnormal endothelial function in young African-American females: discordance with blood flow.

T L Bransford 1, J A St Vrain 1, M Webb 1
PMCID: PMC2593989  PMID: 12653397

Abstract

In this pilot study, we sought to compare the vasodilatory and hemodynamic properties of the peripheral vasculature in the forearms of young, healthy African-American females to similarly matched white females. We used high-resolution ultrasound of the brachial artery to evaluate 11 African-American females and 8 white females. When normalized to nitrate-induced dilation, endothelium-dependent dilation was reduced in young African American females compared to white females (0.6 in African American females compared to 1.0 in white females). These results indicate the need for a larger study to examine this phenomenon.

Full text

PDF
113

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abrams J. Role of endothelial dysfunction in coronary artery disease. Am J Cardiol. 1997 Jun 26;79(12B):2–9. doi: 10.1016/s0002-9149(97)00379-2. [DOI] [PubMed] [Google Scholar]
  2. Anderson N. B., Lane J. D., Muranaka M., Williams R. B., Jr, Houseworth S. J. Racial differences in blood pressure and forearm vascular responses to the cold face stimulus. Psychosom Med. 1988 Jan-Feb;50(1):57–63. doi: 10.1097/00006842-198801000-00007. [DOI] [PubMed] [Google Scholar]
  3. Anderson T. J., Uehata A., Gerhard M. D., Meredith I. T., Knab S., Delagrange D., Lieberman E. H., Ganz P., Creager M. A., Yeung A. C. Close relation of endothelial function in the human coronary and peripheral circulations. J Am Coll Cardiol. 1995 Nov 1;26(5):1235–1241. doi: 10.1016/0735-1097(95)00327-4. [DOI] [PubMed] [Google Scholar]
  4. Bassett D. R., Jr, Duey W. J., Walker A. J., Howley E. T., Bond V. Racial differences in maximal vasodilatory capacity of forearm resistance vessels in normotensive young adults. Am J Hypertens. 1992 Nov;5(11):781–786. doi: 10.1093/ajh/5.11.781. [DOI] [PubMed] [Google Scholar]
  5. Cardillo C., Kilcoyne C. M., Cannon R. O., 3rd, Panza J. A. Attenuation of cyclic nucleotide-mediated smooth muscle relaxation in blacks as a cause of racial differences in vasodilator function. Circulation. 1999 Jan 5;99(1):90–95. doi: 10.1161/01.cir.99.1.90. [DOI] [PubMed] [Google Scholar]
  6. English J. L., Jacobs L. O., Green G., Andrews T. C. Effect of the menstrual cycle on endothelium-dependent vasodilation of the brachial artery in normal young women. Am J Cardiol. 1998 Jul 15;82(2):256–258. doi: 10.1016/s0002-9149(98)00322-1. [DOI] [PubMed] [Google Scholar]
  7. Fichera L. V., Andreassi J. L. Stress and personality as factors in women's cardiovascular reactivity. Int J Psychophysiol. 1998 Mar;28(2):143–155. doi: 10.1016/s0167-8760(97)00092-5. [DOI] [PubMed] [Google Scholar]
  8. Houghton J. L., Carr A. A., Strogatz D. S., Michel A. I., Phillip J. L., Kuhner P. A., Smith V. E., Breisblatt W. M. Coronary vasomotor reactivity among normotensive African and white American subjects with chest pain. Am J Med. 1997 Mar;102(3):245–251. doi: 10.1016/S0002-9343(96)00449-4. [DOI] [PubMed] [Google Scholar]
  9. Houghton J. L., Smith V. E., Strogatz D. S., Henches N. L., Breisblatt W. M., Carr A. A. Effect of African-American race and hypertensive left ventricular hypertrophy on coronary vascular reactivity and endothelial function. Hypertension. 1997 Mar;29(3):706–714. doi: 10.1161/01.hyp.29.3.706. [DOI] [PubMed] [Google Scholar]
  10. Ignarro L. J. Physiology and pathophysiology of nitric oxide. Kidney Int Suppl. 1996 Jun;55:S2–S5. [PubMed] [Google Scholar]
  11. Joannides R., Haefeli W. E., Linder L., Richard V., Bakkali E. H., Thuillez C., Lüscher T. F. Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. Circulation. 1995 Mar 1;91(5):1314–1319. doi: 10.1161/01.cir.91.5.1314. [DOI] [PubMed] [Google Scholar]
  12. Lang C. C., Stein C. M., Brown R. M., Deegan R., Nelson R., He H. B., Wood M., Wood A. J. Attenuation of isoproterenol-mediated vasodilatation in blacks. N Engl J Med. 1995 Jul 20;333(3):155–160. doi: 10.1056/NEJM199507203330304. [DOI] [PubMed] [Google Scholar]
  13. McCrohon J. A., Woo K. S., Celermajer D. S. A comparison of endothelial function in Caucasian and Chinese women before and after the menopause. Maturitas. 2000 Apr 28;35(1):31–37. doi: 10.1016/s0378-5122(00)00102-x. [DOI] [PubMed] [Google Scholar]
  14. Ruschitzka F. T., Noll G., Lüscher T. F. The endothelium in coronary artery disease. Cardiology. 1997;88 (Suppl 3):3–19. doi: 10.1159/000177500. [DOI] [PubMed] [Google Scholar]
  15. Sorensen K. E., Kristensen I. B., Celermajer D. S. Atherosclerosis in the human brachial artery. J Am Coll Cardiol. 1997 Feb;29(2):318–322. doi: 10.1016/s0735-1097(96)00474-3. [DOI] [PubMed] [Google Scholar]
  16. Stein C. M., Lang C. C., Nelson R., Brown M., Wood A. J. Vasodilation in black Americans: attenuated nitric oxide-mediated responses. Clin Pharmacol Ther. 1997 Oct;62(4):436–443. doi: 10.1016/S0009-9236(97)90122-3. [DOI] [PubMed] [Google Scholar]
  17. Thomas J., Thomas D. J., Pearson T., Klag M., Mead L. Cardiovascular disease in African American and white physicians: the Meharry Cohort and Meharry-Hopkins Cohort Studies. J Health Care Poor Underserved. 1997 Aug;8(3):270–284. doi: 10.1353/hpu.2010.0526. [DOI] [PubMed] [Google Scholar]
  18. Uehata A., Lieberman E. H., Gerhard M. D., Anderson T. J., Ganz P., Polak J. F., Creager M. A., Yeung A. C. Noninvasive assessment of endothelium-dependent flow-mediated dilation of the brachial artery. Vasc Med. 1997;2(2):87–92. doi: 10.1177/1358863X9700200203. [DOI] [PubMed] [Google Scholar]

Articles from Journal of the National Medical Association are provided here courtesy of National Medical Association

RESOURCES