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. 2001 Jul-Aug;93(7-8):282–287.

Thoracic aortic dissection in a patient with autosomal dominant polycystic kidney disease.

T Adeola 1, O Adeleye 1, J L Potts 1, M Faulkner 1, A Oso 1
PMCID: PMC2594041  PMID: 11491280

Abstract

Autosomal dominant polycystic kidney disease is one of the most common hereditary diseases, and frequently has well defined extrarenal manifestations. Very few cases of aortic aneurysms associated with this disorder are described in literature. We report a 42-year-old male with autosomal dominant polycystic kidney disease presenting with dissecting aneurysm of the thoracic aorta.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Biagini A., Maffei S., Baroni M., Piacenti M., Terrazzi M., Paoli F., Trianni G., Picano E., Salvatore L. Familiar clustering of aortic dissection in polycystic kidney disease. Am J Cardiol. 1993 Sep 15;72(9):741–742. doi: 10.1016/0002-9149(93)90896-k. [DOI] [PubMed] [Google Scholar]
  2. Biermann C. W., Rutishauser G. Polycystic kidneys associated with Marfan syndrome in an adult. Scand J Urol Nephrol. 1994 Sep;28(3):295–296. [PubMed] [Google Scholar]
  3. Chapman A. B., Rubinstein D., Hughes R., Stears J. C., Earnest M. P., Johnson A. M., Gabow P. A., Kaehny W. D. Intracranial aneurysms in autosomal dominant polycystic kidney disease. N Engl J Med. 1992 Sep 24;327(13):916–920. doi: 10.1056/NEJM199209243271303. [DOI] [PubMed] [Google Scholar]
  4. Chapman J. R., Hilson A. J. Polycystic kidneys and abdominal aortic aneurysms. Lancet. 1980 Mar 22;1(8169):646–647. doi: 10.1016/s0140-6736(80)91135-6. [DOI] [PubMed] [Google Scholar]
  5. Gabow P. A. Autosomal dominant polycystic kidney disease. N Engl J Med. 1993 Jul 29;329(5):332–342. doi: 10.1056/NEJM199307293290508. [DOI] [PubMed] [Google Scholar]
  6. Grantham J. J. The etiology, pathogenesis, and treatment of autosomal dominant polycystic kidney disease: recent advances. Am J Kidney Dis. 1996 Dec;28(6):788–803. doi: 10.1016/s0272-6386(96)90378-9. [DOI] [PubMed] [Google Scholar]
  7. Griffin M. D., Torres V. E., Grande J. P., Kumar R. Vascular expression of polycystin. J Am Soc Nephrol. 1997 Apr;8(4):616–626. doi: 10.1681/ASN.V84616. [DOI] [PubMed] [Google Scholar]
  8. Hartman D. S. Genitourinary case of the day. Autosomal dominant polycystic kidney disease complicated by thoracic aortic dissection. AJR Am J Roentgenol. 1994 Jun;162(6):1454–1454. doi: 10.2214/ajr.162.6.8192022. [DOI] [PubMed] [Google Scholar]
  9. Hossack K. F., Leddy C. L., Johnson A. M., Schrier R. W., Gabow P. A. Echocardiographic findings in autosomal dominant polycystic kidney disease. N Engl J Med. 1988 Oct 6;319(14):907–912. doi: 10.1056/NEJM198810063191404. [DOI] [PubMed] [Google Scholar]
  10. Jacobs L. E., Fraifeld M., Kotler M. N., Ioli A. W. Aortic dissection following intraaortic balloon insertion: recognition by transesophageal echocardiography. Am Heart J. 1992 Aug;124(2):536–540. doi: 10.1016/0002-8703(92)90631-5. [DOI] [PubMed] [Google Scholar]
  11. Kimberling W. J., Kumar S., Gabow P. A., Kenyon J. B., Connolly C. J., Somlo S. Autosomal dominant polycystic kidney disease: localization of the second gene to chromosome 4q13-q23. Genomics. 1993 Dec;18(3):467–472. doi: 10.1016/s0888-7543(11)80001-7. [DOI] [PubMed] [Google Scholar]
  12. Larson E. W., Edwards W. D. Risk factors for aortic dissection: a necropsy study of 161 cases. Am J Cardiol. 1984 Mar 1;53(6):849–855. doi: 10.1016/0002-9149(84)90418-1. [DOI] [PubMed] [Google Scholar]
  13. Liu Y., Zhang H., Zhong H. [Systemic manifestations of adult polycystic kidney disease: an analysis of 205 cases]. Zhonghua Nei Ke Za Zhi. 1995 Sep;34(9):612–615. [PubMed] [Google Scholar]
  14. Paynter H. E., Parnham A., Feest T. G., Dudley C. R. Thoracic aortic dissection complicating autosomal dominant polycystic kidney disease. Nephrol Dial Transplant. 1997 Aug;12(8):1711–1713. doi: 10.1093/ndt/12.8.1711. [DOI] [PubMed] [Google Scholar]
  15. Reeders S. T., Breuning M. H., Davies K. E., Nicholls R. D., Jarman A. P., Higgs D. R., Pearson P. L., Weatherall D. J. A highly polymorphic DNA marker linked to adult polycystic kidney disease on chromosome 16. Nature. 1985 Oct 10;317(6037):542–544. doi: 10.1038/317542a0. [DOI] [PubMed] [Google Scholar]
  16. Robertson A. J., Morris P. J. Dissection of the thoracic aorta in renal transplant patients with polycystic kidney disease. Aust N Z J Surg. 1999 Apr;69(4):324–326. doi: 10.1046/j.1440-1622.1999.01545.x. [DOI] [PubMed] [Google Scholar]
  17. Scheff R. T., Zuckerman G., Harter H., Delmez J., Koehler R. Diverticular disease in patients with chronic renal failure due to polycystic kidney disease. Ann Intern Med. 1980 Feb;92(2 Pt 1):202–204. doi: 10.7326/0003-4819-92-2-202. [DOI] [PubMed] [Google Scholar]
  18. Spittell P. C., Spittell J. A., Jr, Joyce J. W., Tajik A. J., Edwards W. D., Schaff H. V., Stanson A. W. Clinical features and differential diagnosis of aortic dissection: experience with 236 cases (1980 through 1990). Mayo Clin Proc. 1993 Jul;68(7):642–651. doi: 10.1016/s0025-6196(12)60599-0. [DOI] [PubMed] [Google Scholar]
  19. Torra R., Nicolau C., Badenas C., Navarro S., Pérez L., Estivill X., Darnell A. Ultrasonographic study of pancreatic cysts in autosomal dominant polycystic kidney disease. Clin Nephrol. 1997 Jan;47(1):19–22. [PubMed] [Google Scholar]
  20. Vanmaele R., Witbreuk M., De Broe M., Van Schil P., Lins R. Abdominal aortic aneurysm and polycystic kidneys. Nephron. 1995;69(1):107–108. doi: 10.1159/000188378. [DOI] [PubMed] [Google Scholar]
  21. Watnick T., Germino G. G. Molecular basis of autosomal dominant polycystic kidney disease. Semin Nephrol. 1999 Jul;19(4):327–343. [PubMed] [Google Scholar]
  22. Williams G. M., Gott V. L., Brawley R. K., Schauble J. F., Labs J. D. Aortic disease associated with pregnancy. J Vasc Surg. 1988 Oct;8(4):470–475. [PubMed] [Google Scholar]
  23. Wilson P. D., Schrier R. W., Breckon R. D., Gabow P. A. A new method for studying human polycystic kidney disease epithelia in culture. Kidney Int. 1986 Sep;30(3):371–378. doi: 10.1038/ki.1986.194. [DOI] [PubMed] [Google Scholar]

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