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. 1988 Apr;56(4):998–999. doi: 10.1128/iai.56.4.998-999.1988

Protection of rabbits in an infection model of toxic shock syndrome (TSS) by a TSS toxin-1-specific monoclonal antibody.

G K Best 1, D F Scott 1, J M Kling 1, M R Thompson 1, L E Adinolfi 1, P F Bonventre 1
PMCID: PMC259405  PMID: 3346079

Abstract

An anti-TSST-1-specific monoclonal antibody (MAb 8-5-7) was tested for its protective capacity in a rabbit infection model to toxic shock syndrome (TSS). The challenge strain of Staphylococcus aureus (RN4710), which contained a plasmid encoding TSS toxin-1, was introduced into previously implanted chambers. Purified monoclonal antibody (1.25 mg of immunoglobulin G) administered parenterally 1 day before and 1 day after initiation of infection provided complete protection against the TSS-like syndrome and the mortality which occurred in unprotected rabbits.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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