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. 1988 Apr;56(4):1000–1002. doi: 10.1128/iai.56.4.1000-1002.1988

Effect of protein malnutrition on salmonellosis and fever.

S F Bradley 1, C A Kauffman 1
PMCID: PMC259406  PMID: 3346070

Abstract

Protein-malnourished rats had greater numbers of bacteria in their livers and spleens compared with numbers in control rats following a sublethal intraperitoneal dose of Salmonella typhimurium. However, the febrile responses of both groups of rats to infection were similar. The ability to mount a normal febrile response does not necessarily reflect the ability of the host to contain an infection.

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Selected References

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  1. Abbott W. C., Tayek J. A., Bistrian B. R., Maki T., Ainsley B. M., Reid L. A., Blackburn G. L. The effect of nutritional support on T-lymphocyte subpopulations in protein calorie malnutrition. J Am Coll Nutr. 1986;5(6):577–584. doi: 10.1080/07315724.1986.10720158. [DOI] [PubMed] [Google Scholar]
  2. Bistrian B. R., Blackburn G. L., Scrimshaw N. S., Flatt J. P. Cellular immunity in semistarved states in hospitalized adults. Am J Clin Nutr. 1975 Oct;28(10):1148–1155. doi: 10.1093/ajcn/28.10.1148. [DOI] [PubMed] [Google Scholar]
  3. Blanden R. V., Mackaness G. B., Collins F. M. Mechanisms of acquired resistance in mouse typhoid. J Exp Med. 1966 Oct 1;124(4):585–600. doi: 10.1084/jem.124.4.585. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bradley S. F., Kauffman C. A. Protein malnutrition and the febrile response in the Fischer rat. J Leukoc Biol. 1988 Jan;43(1):36–40. doi: 10.1002/jlb.43.1.36. [DOI] [PubMed] [Google Scholar]
  5. Bradley S. F., Kluger M. J., Kauffman C. A. Age and protein malnutrition: effects on the febrile response. Gerontology. 1987;33(2):99–108. doi: 10.1159/000212859. [DOI] [PubMed] [Google Scholar]
  6. Brenton D. P., Brown R. E., Wharton B. A. Hypothermia in kwashiorkor. Lancet. 1967 Feb 25;1(7487):410–413. doi: 10.1016/s0140-6736(67)91175-0. [DOI] [PubMed] [Google Scholar]
  7. Bryant R. E., Hood A. F., Hood C. E., Koenig M. G. Factors affecting mortality of gram-negative rod bacteremia. Arch Intern Med. 1971 Jan;127(1):120–128. [PubMed] [Google Scholar]
  8. Finkelstein M. S., Petkun W. M., Freedman M. L., Antopol S. C. Pneumococcal bacteremia in adults: age-dependent differences in presentation and in outcome. J Am Geriatr Soc. 1983 Jan;31(1):19–27. doi: 10.1111/j.1532-5415.1983.tb06283.x. [DOI] [PubMed] [Google Scholar]
  9. Hoffman-Goetz L., Kluger M. J. Protein deprivation: its effects on fever and plasma iron during bacterial infection in rabbits. J Physiol. 1979 Oct;295:419–430. doi: 10.1113/jphysiol.1979.sp012977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Hoffman-Goetz L., McFarlane D., Bistrian B. R., Blackburn G. L. Febrile and plasma iron responses of rabbits injected with endogenous pyrogen from malnourished patients. Am J Clin Nutr. 1981 Jun;34(6):1109–1116. doi: 10.1093/ajcn/34.6.1109. [DOI] [PubMed] [Google Scholar]
  11. Ispahani P., Pearson N. J., Greenwood D. An analysis of community and hospital-acquired bacteraemia in a large teaching hospital in the United Kingdom. Q J Med. 1987 May;63(241):427–440. [PubMed] [Google Scholar]
  12. Kauffman C. A., Jones P. G., Kluger M. J. Fever and malnutrition: endogenous pyrogen/interleukin-1 in malnourished patients. Am J Clin Nutr. 1986 Oct;44(4):449–452. doi: 10.1093/ajcn/44.4.449. [DOI] [PubMed] [Google Scholar]
  13. Keenan R. A., Moldawer L. L., Yang R. D., Kawamura I., Blackburn G. L., Bistrian B. R. An altered response by peripheral leukocytes to synthesize or release leukocyte endogenous mediator in critically ill, protein-malnourished patients. J Lab Clin Med. 1982 Dec;100(6):844–857. [PubMed] [Google Scholar]
  14. Keusch G. T., Douglas S. D., Braden K., Geller S. A. Antibacterial functions of macrophages in experimental protein-calorie malnutrition. I. Description of the model, morphologic observations, and macrophage surface IgG receptors. J Infect Dis. 1978 Aug;138(2):125–133. doi: 10.1093/infdis/138.2.125. [DOI] [PubMed] [Google Scholar]
  15. Keusch G. T., Douglas S. D., Hammer G., Braden K. Antibacterial functions of macrophages in experimental protein-calorie malnutrition. II. Cellular and humoral factors for chemotaxis, phagocytosis, and intracellular bactericidal activity. J Infect Dis. 1978 Aug;138(2):134–142. doi: 10.1093/infdis/138.2.134. [DOI] [PubMed] [Google Scholar]
  16. Kluger M. J. The evolution and adaptive value of fever. Am Sci. 1978 Jan-Feb;66(1):38–43. [PubMed] [Google Scholar]
  17. Kreger B. E., Craven D. E., McCabe W. R. Gram-negative bacteremia. IV. Re-evaluation of clinical features and treatment in 612 patients. Am J Med. 1980 Mar;68(3):344–355. doi: 10.1016/0002-9343(80)90102-3. [DOI] [PubMed] [Google Scholar]
  18. Mackaness G. B., Blanden R. V., Collins F. M. Host-parasite relations in mouse typhoid. J Exp Med. 1966 Oct 1;124(4):573–583. doi: 10.1084/jem.124.4.573. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Montgomerie J. Z., Ota J. K. Klebsiella bacteremia. Arch Intern Med. 1980 Apr;140(4):525–527. [PubMed] [Google Scholar]
  20. Slonecker C. E., Osmanski P. The effects of protein deficiency on acute inflammatory responses in rats. J Reticuloendothel Soc. 1974 Oct;16(4):239–251. [PubMed] [Google Scholar]
  21. Smythe P. M., Brereton-Stiles G. G., Grace H. J., Mafoyane A., Schonland M., Coovadia H. M., Loening W. E., Parent M. A., Vos G. H. Thymolymphatic deficiency and depression of cell-mediated immunity in protein-calorie malnutrition. Lancet. 1971 Oct 30;2(7731):939–943. doi: 10.1016/s0140-6736(71)90267-4. [DOI] [PubMed] [Google Scholar]
  22. Tocco-Bradley R., Kluger M. J., Kauffman C. A. Effect of age on fever and acute-phase response of rats to endotoxin and Salmonella typhimurium. Infect Immun. 1985 Jan;47(1):106–111. doi: 10.1128/iai.47.1.106-111.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Tulp O. L., Krupp P. P., Danforth E., Jr, Horton E. S. Characteristics of thyroid function in experimental protein malnutrition. J Nutr. 1979 Jul;109(7):1321–1332. doi: 10.1093/jn/109.7.1321. [DOI] [PubMed] [Google Scholar]
  24. Weinstein M. P., Iannini P. B., Stratton C. W., Eickhoff T. C. Spontaneous bacterial peritonitis. A review of 28 cases with emphasis on improved survival and factors influencing prognosis. Am J Med. 1978 Apr;64(4):592–598. doi: 10.1016/0002-9343(78)90578-8. [DOI] [PubMed] [Google Scholar]
  25. Weinstein M. P., Murphy J. R., Reller L. B., Lichtenstein K. A. The clinical significance of positive blood cultures: a comprehensive analysis of 500 episodes of bacteremia and fungemia in adults. II. Clinical observations, with special reference to factors influencing prognosis. Rev Infect Dis. 1983 Jan-Feb;5(1):54–70. doi: 10.1093/clinids/5.1.54. [DOI] [PubMed] [Google Scholar]

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