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. 2003 Jun;95(6):475–482.

Osteoarthritis: understanding the pathophysiology, genetics, and treatments.

Vladamir Sinkov 1, Tyler Cymet 1
PMCID: PMC2594535  PMID: 12856913

Abstract

Risk factors for developing osteoarthritis include age, previous joint injury, obesity, and a genetic predisposition. An imbalance of joint functioning initiates the disease process, which is then worsened through biochemical changes in the collagen in the joint. Joint pain is the cardinal clinical presentation. Radiographic and lab testing do not correlate well with the disease; therefore, diagnosis is made by clinical findings. Treatment focuses on maintaining joint function through the use of directed activity, physical therapy, and medications.

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Selected References

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