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. 2003 Dec;95(12):1170–1183.

Birthweight, rapid growth, cancer, and longevity: a review.

Thomas T Samaras 1, Harold Elrick 1, Lowell H Storms 1
PMCID: PMC2594855  PMID: 14717473

Abstract

The fetal growth restriction hypothesis states that retarded growth in utero promotes health problems later in life. While most of the studies on intrauterine growth retardation (as measured by birthweight) confirm this hypothesis, many researchers have found flaws in these studies. In addition, many studies have found either no correlation or a positive relation between birthweight (BW) and adult blood pressure or mortality. Furthermore, high BW leads to greater adult obesity and chronic disease, and increasing macrosomia in newborns raises the risk for birth-related problems. Increased cancer risk is also tied to higher BW, and catch-up or accelerated growth generally has negative health effects. Adult height has been found to correlate with greater BW and birthlength (BL), and several studies have found an inverse relation between height and longevity. Paradoxical findings, such as lower BW and low levels of cardiovascular disease in the developing world, are presented. Within 25 years, genetic engineering will allow in utero alterations to the fetus, resulting in higher BW and taller adults. The authors suggest that increased BW leading to larger adult body size has dangerous implications in terms of human health and survival.

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Selected References

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  1. Albanes D. Height, early energy intake, and cancer. Evidence mounts for the relation of energy intake to adult malignancies. BMJ. 1998 Nov 14;317(7169):1331–1332. doi: 10.1136/bmj.317.7169.1331. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Amador M., Bacallao J., Hermelo M. Adiposity and growth: relationship of stature at fourteen years with relative body weight at different ages and several measures of adiposity and body bulk. Eur J Clin Nutr. 1992 Mar;46(3):213–219. [PubMed] [Google Scholar]
  3. Barker D. J., Osmond C., Golding J., Kuh D., Wadsworth M. E. Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease. BMJ. 1989 Mar 4;298(6673):564–567. doi: 10.1136/bmj.298.6673.564. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Barker D. J., Winter P. D., Osmond C., Phillips D. I., Sultan H. Y. Weight gain in infancy and cancer of the ovary. Lancet. 1995 Apr 29;345(8957):1087–1088. doi: 10.1016/s0140-6736(95)90821-8. [DOI] [PubMed] [Google Scholar]
  5. Bartke A. Delayed aging in Ames dwarf mice. Relationships to endocrine function and body size. Results Probl Cell Differ. 2000;29:181–202. doi: 10.1007/978-3-540-48003-7_10. [DOI] [PubMed] [Google Scholar]
  6. Bergel E., Haelterman E., Belizán J., Villar J., Carroli G. Perinatal factors associated with blood pressure during childhood. Am J Epidemiol. 2000 Mar 15;151(6):594–601. doi: 10.1093/oxfordjournals.aje.a010247. [DOI] [PubMed] [Google Scholar]
  7. Bruining G. J. Association between infant growth before onset of juvenile type-1 diabetes and autoantibodies to IA-2. Netherlands Kolibrie study group of childhood diabetes. Lancet. 2000 Aug 19;356(9230):655–656. doi: 10.1016/s0140-6736(00)02612-x. [DOI] [PubMed] [Google Scholar]
  8. Christensen K., Vaupel J. W., Holm N. V., Yashin A. I. Mortality among twins after age 6: fetal origins hypothesis versus twin method. BMJ. 1995 Feb 18;310(6977):432–436. doi: 10.1136/bmj.310.6977.432. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Dahlquist G. G., Patterson C., Soltesz G. Perinatal risk factors for childhood type 1 diabetes in Europe. The EURODIAB Substudy 2 Study Group. Diabetes Care. 1999 Oct;22(10):1698–1702. doi: 10.2337/diacare.22.10.1698. [DOI] [PubMed] [Google Scholar]
  10. Demissie K., Rhoads G. G., Ananth C. V., Alexander G. R., Kramer M. S., Kogan M. D., Joseph K. S. Trends in preterm birth and neonatal mortality among blacks and whites in the United States from 1989 to 1997. Am J Epidemiol. 2001 Aug 15;154(4):307–315. doi: 10.1093/aje/154.4.307. [DOI] [PubMed] [Google Scholar]
  11. Ekbom A., Hsieh C. C., Lipworth L., Wolk A., Pontén J., Adami H. O., Trichopoulos D. Perinatal characteristics in relation to incidence of and mortality from prostate cancer. BMJ. 1996 Aug 10;313(7053):337–341. doi: 10.1136/bmj.313.7053.337. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Erhardt E., Molnár D., Storcz J., Márkus A., Török K. Az intrauterin tápláltság szerepe a cardiovascularis kockázati tényezök alakulásában 6-10 éves gyermekekben. Orv Hetil. 1999 Nov 14;140(46):2563–2567. [PubMed] [Google Scholar]
  13. Eriksson J. G., Forsén T., Tuomilehto J., Osmond C., Barker D. J. Early growth and coronary heart disease in later life: longitudinal study. BMJ. 2001 Apr 21;322(7292):949–953. doi: 10.1136/bmj.322.7292.949. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Eriksson J. G., Forsén T., Tuomilehto J., Osmond C., Barker D. J. Early growth, adult income, and risk of stroke. Stroke. 2000 Apr;31(4):869–874. doi: 10.1161/01.str.31.4.869. [DOI] [PubMed] [Google Scholar]
  15. Eriksson J., Forsén T., Tuomilehto J., Osmond C., Barker D. Size at birth, childhood growth and obesity in adult life. Int J Obes Relat Metab Disord. 2001 May;25(5):735–740. doi: 10.1038/sj.ijo.0801602. [DOI] [PubMed] [Google Scholar]
  16. Farrell P. M., Kosorok M. R., Rock M. J., Laxova A., Zeng L., Lai H. C., Hoffman G., Laessig R. H., Splaingard M. L. Early diagnosis of cystic fibrosis through neonatal screening prevents severe malnutrition and improves long-term growth. Wisconsin Cystic Fibrosis Neonatal Screening Study Group. Pediatrics. 2001 Jan;107(1):1–13. doi: 10.1542/peds.107.1.1. [DOI] [PubMed] [Google Scholar]
  17. Field A. E., Coakley E. H., Must A., Spadano J. L., Laird N., Dietz W. H., Rimm E., Colditz G. A. Impact of overweight on the risk of developing common chronic diseases during a 10-year period. Arch Intern Med. 2001 Jul 9;161(13):1581–1586. doi: 10.1001/archinte.161.13.1581. [DOI] [PubMed] [Google Scholar]
  18. Fleisher Barry E., Baum David, Brudos Ginger, Burge Mary, Carson Elaine, Constantinou Janet, Duckworth Josh, Gamberg Pat, Klein Pat, Luikart Helen. Infant heart transplantation at Stanford: growth and neurodevelopmental outcome. Pediatrics. 2002 Jan;109(1):1–7. doi: 10.1542/peds.109.1.1. [DOI] [PubMed] [Google Scholar]
  19. Forsén T., Eriksson J., Tuomilehto J., Reunanen A., Osmond C., Barker D. The fetal and childhood growth of persons who develop type 2 diabetes. Ann Intern Med. 2000 Aug 1;133(3):176–182. doi: 10.7326/0003-4819-133-3-200008010-00008. [DOI] [PubMed] [Google Scholar]
  20. Freedman D. S., Khan L. K., Serdula M. K., Srinivasan S. R., Berenson G. S. Secular trends in height among children during 2 decades: The Bogalusa Heart Study. Arch Pediatr Adolesc Med. 2000 Feb;154(2):155–161. doi: 10.1001/archpedi.154.2.155. [DOI] [PubMed] [Google Scholar]
  21. Gillman Matthew W. Epidemiological challenges in studying the fetal origins of adult chronic disease. Int J Epidemiol. 2002 Apr;31(2):294–299. [PubMed] [Google Scholar]
  22. Gunnell D., Okasha M., Smith G. D., Oliver S. E., Sandhu J., Holly J. M. Height, leg length, and cancer risk: a systematic review. Epidemiol Rev. 2001;23(2):313–342. doi: 10.1093/oxfordjournals.epirev.a000809. [DOI] [PubMed] [Google Scholar]
  23. Henneberg M. Evolution of the human brain: is bigger better? Clin Exp Pharmacol Physiol. 1998 Sep;25(9):745–749. doi: 10.1111/j.1440-1681.1998.tb02289.x. [DOI] [PubMed] [Google Scholar]
  24. Henry O. A., Guaran R. L., Petterson C. D., Walstab J. E. Obstetric and birthweight differences between Vietnam-born and Australian-born women. Med J Aust. 1992 Mar 2;156(5):321–324. doi: 10.5694/j.1326-5377.1992.tb139788.x. [DOI] [PubMed] [Google Scholar]
  25. Hu F. B., Wang B., Chen C., Jin Y., Yang J., Stampfer M. J., Xu X. Body mass index and cardiovascular risk factors in a rural Chinese population. Am J Epidemiol. 2000 Jan 1;151(1):88–97. doi: 10.1093/oxfordjournals.aje.a010127. [DOI] [PubMed] [Google Scholar]
  26. Hulman S., Kushner H., Katz S., Falkner B. Can cardiovascular risk be predicted by newborn, childhood, and adolescent body size? An examination of longitudinal data in urban African Americans. J Pediatr. 1998 Jan;132(1):90–97. doi: 10.1016/s0022-3476(98)70491-3. [DOI] [PubMed] [Google Scholar]
  27. Huxley R. R., Shiell A. W., Law C. M. The role of size at birth and postnatal catch-up growth in determining systolic blood pressure: a systematic review of the literature. J Hypertens. 2000 Jul;18(7):815–831. doi: 10.1097/00004872-200018070-00002. [DOI] [PubMed] [Google Scholar]
  28. Huxley Rachel, Neil Andrew, Collins Rory. Unravelling the fetal origins hypothesis: is there really an inverse association between birthweight and subsequent blood pressure? Lancet. 2002 Aug 31;360(9334):659–665. doi: 10.1016/S0140-6736(02)09834-3. [DOI] [PubMed] [Google Scholar]
  29. Joseph K. S., Kramer M. S. Review of the evidence on fetal and early childhood antecedents of adult chronic disease. Epidemiol Rev. 1996;18(2):158–174. doi: 10.1093/oxfordjournals.epirev.a017923. [DOI] [PubMed] [Google Scholar]
  30. Kramer M. S. Invited commentary: association between restricted fetal growth and adult chronic disease: is it causal? Is it important? Am J Epidemiol. 2000 Oct 1;152(7):605–608. doi: 10.1093/aje/152.7.605. [DOI] [PubMed] [Google Scholar]
  31. Laor A., Stevenson D. K., Shemer J., Gale R., Seidman D. S. Size at birth, maternal nutritional status in pregnancy, and blood pressure at age 17: population based analysis. BMJ. 1997 Aug 23;315(7106):449–453. doi: 10.1136/bmj.315.7106.449. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Leon D. A., Johansson M., Rasmussen F. Gestational age and growth rate of fetal mass are inversely associated with systolic blood pressure in young adults: an epidemiologic study of 165,136 Swedish men aged 18 years. Am J Epidemiol. 2000 Oct 1;152(7):597–604. doi: 10.1093/aje/152.7.597. [DOI] [PubMed] [Google Scholar]
  33. Lindeberg S., Nilsson-Ehle P., Terént A., Vessby B., Scherstén B. Cardiovascular risk factors in a Melanesian population apparently free from stroke and ischaemic heart disease: the Kitava study. J Intern Med. 1994 Sep;236(3):331–340. doi: 10.1111/j.1365-2796.1994.tb00804.x. [DOI] [PubMed] [Google Scholar]
  34. Lucas A., Fewtrell M. S., Cole T. J. Fetal origins of adult disease-the hypothesis revisited. BMJ. 1999 Jul 24;319(7204):245–249. doi: 10.1136/bmj.319.7204.245. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Martorell R., Stein A. D., Schroeder D. G. Early nutrition and later adiposity. J Nutr. 2001 Mar;131(3):874S–880S. doi: 10.1093/jn/131.3.874S. [DOI] [PubMed] [Google Scholar]
  36. Meeuwisse G., Olausson P. O. Okad födelsevikt i Norden. Allt större andel nyfödda väger över fyra kilo. Lakartidningen. 1998 Nov 25;95(48):5488–5492. [PubMed] [Google Scholar]
  37. Melve K. K., Gjessing H. K., Skjaerven R., Oyen N. Infants' length at birth: an independent effect on perinatal mortality. Acta Obstet Gynecol Scand. 2000 Jun;79(6):459–464. [PubMed] [Google Scholar]
  38. Michels K. B., Trichopoulos D., Robins J. M., Rosner B. A., Manson J. E., Hunter D. J., Colditz G. A., Hankinson S. E., Speizer F. E., Willett W. C. Birthweight as a risk factor for breast cancer. Lancet. 1996 Dec 7;348(9041):1542–1546. doi: 10.1016/S0140-6736(96)03102-9. [DOI] [PubMed] [Google Scholar]
  39. Okasha Mona, Gunnell David, Holly Jeffrey, Davey Smith George. Childhood growth and adult cancer. Best Pract Res Clin Endocrinol Metab. 2002 Jun;16(2):225–241. doi: 10.1053/beem.2002.0204. [DOI] [PubMed] [Google Scholar]
  40. Oken Emily, Gillman Matthew W. Fetal origins of obesity. Obes Res. 2003 Apr;11(4):496–506. doi: 10.1038/oby.2003.69. [DOI] [PubMed] [Google Scholar]
  41. Ong K. K., Ahmed M. L., Emmett P. M., Preece M. A., Dunger D. B. Association between postnatal catch-up growth and obesity in childhood: prospective cohort study. BMJ. 2000 Apr 8;320(7240):967–971. doi: 10.1136/bmj.320.7240.967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Parsons T. J., Power C., Manor O. Fetal and early life growth and body mass index from birth to early adulthood in 1958 British cohort: longitudinal study. BMJ. 2001 Dec 8;323(7325):1331–1335. doi: 10.1136/bmj.323.7325.1331. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Paz I., Laor A., Gale R., Harlap S., Stevenson D. K., Seidman D. S. Term infants with fetal growth restriction are not at increased risk for low intelligence scores at age 17 years. J Pediatr. 2001 Jan;138(1):87–91. doi: 10.1067/mpd.2001.110131. [DOI] [PubMed] [Google Scholar]
  44. Pietiläinen K. H., Kaprio J., Räsänen M., Winter T., Rissanen A., Rose R. J. Tracking of body size from birth to late adolescence: contributions of birth length, birth weight, duration of gestation, parents' body size, and twinship. Am J Epidemiol. 2001 Jul 1;154(1):21–29. doi: 10.1093/aje/154.1.21. [DOI] [PubMed] [Google Scholar]
  45. Popkin B. M., Doak C. M. The obesity epidemic is a worldwide phenomenon. Nutr Rev. 1998 Apr;56(4 Pt 1):106–114. doi: 10.1111/j.1753-4887.1998.tb01722.x. [DOI] [PubMed] [Google Scholar]
  46. Posthuma D., De Geus E. J., Bleichrodt N., Boomsma D. I. Twin-singleton differences in intelligence? Twin Res. 2000 Jun;3(2):83–87. doi: 10.1375/136905200320565535. [DOI] [PubMed] [Google Scholar]
  47. Rabbia F., Veglio F., Grosso T., Nacca R., Martini G., Riva P., di Cella S. M., Schiavone D., Chiandussi L. Relationship between birth weight and blood pressure in adolescence. Prev Med. 1999 Dec;29(6 Pt 1):455–459. doi: 10.1006/pmed.1999.0577. [DOI] [PubMed] [Google Scholar]
  48. Rantakallio P., Lärä E., Koiranen M., Sarpola A. Maternal build and pregnancy outcome. J Clin Epidemiol. 1995 Feb;48(2):199–207. doi: 10.1016/0895-4356(94)00130-i. [DOI] [PubMed] [Google Scholar]
  49. Rasmussen F., Johansson M. The relation of weight, length and ponderal index at birth to body mass index and overweight among 18-year-old males in Sweden. Eur J Epidemiol. 1998 Jun;14(4):373–380. doi: 10.1023/a:1007411613576. [DOI] [PubMed] [Google Scholar]
  50. Richards Marcus, Hardy Rebecca, Kuh Diana, Wadsworth Michael E. J. Birthweight, postnatal growth and cognitive function in a national UK birth cohort. Int J Epidemiol. 2002 Apr;31(2):342–348. [PubMed] [Google Scholar]
  51. Rollo C. David. Growth negatively impacts the life span of mammals. Evol Dev. 2002 Jan-Feb;4(1):55–61. doi: 10.1046/j.1525-142x.2002.01053.x. [DOI] [PubMed] [Google Scholar]
  52. Roseboom T. J., van der Meulen J. H., Osmond C., Barker D. J., Ravelli A. C., Bleker O. P. Adult survival after prenatal exposure to the Dutch famine 1944--45. Paediatr Perinat Epidemiol. 2001 Jul;15(3):220–225. doi: 10.1046/j.1365-3016.2001.00336.x. [DOI] [PubMed] [Google Scholar]
  53. Roth George S., Lane Mark A., Ingram Donald K., Mattison Julie A., Elahi Dariush, Tobin Jordan D., Muller Denis, Metter E. Jeffrey. Biomarkers of caloric restriction may predict longevity in humans. Science. 2002 Aug 2;297(5582):811–811. doi: 10.1126/science.1071851. [DOI] [PubMed] [Google Scholar]
  54. Rush D. Maternal nutrition and perinatal survival. Nutr Rev. 2001 Oct;59(10):315–326. doi: 10.1111/j.1753-4887.2001.tb06956.x. [DOI] [PubMed] [Google Scholar]
  55. Samaras T. T., Elrick H. Height, body size and longevity. Acta Med Okayama. 1999 Aug;53(4):149–169. [PubMed] [Google Scholar]
  56. Samaras T. T., Storms L. H. Impact of height and weight on life span. Bull World Health Organ. 1992;70(2):259–267. [PMC free article] [PubMed] [Google Scholar]
  57. Samaras T. T., Storms L. H. Secular growth and its harmful ramifications. Med Hypotheses. 2002 Feb;58(2):93–112. doi: 10.1054/mehy.2001.1463. [DOI] [PubMed] [Google Scholar]
  58. Samaras Thomas T., Elrick Harold, Storms Lowell H. Is height related to longevity? Life Sci. 2003 Mar 7;72(16):1781–1802. doi: 10.1016/s0024-3205(02)02503-1. [DOI] [PubMed] [Google Scholar]
  59. Samaras Thomas T., Storms Lowell H., Elrick Harold. Longevity, mortality and body weight. Ageing Res Rev. 2002 Sep;1(4):673–691. doi: 10.1016/s1568-1637(02)00029-6. [DOI] [PubMed] [Google Scholar]
  60. Sauitz D. A. Can children's health be predicted by perinatal health? Int J Epidemiol. 2000 Feb;29(1):189–190. doi: 10.1093/ije/29.1.189. [DOI] [PubMed] [Google Scholar]
  61. Seidman D. S., Gale R., Stevenson D. K., Laor A., Bettane P. A., Danon Y. L. Is the association between birthweight and height attainment independent of the confounding effect of ethnic and socioeconomic factors? Isr J Med Sci. 1993 Dec;29(12):772–776. [PubMed] [Google Scholar]
  62. Seidman D. S., Laor A., Gale R., Stevenson D. K., Danon Y. L. A longitudinal study of birth weight and being overweight in late adolescence. Am J Dis Child. 1991 Jul;145(7):782–785. [PubMed] [Google Scholar]
  63. Seidman D. S., Laor A., Gale R., Stevenson D. K., Mashiach S., Danon Y. L. Birth weight, current body weight, and blood pressure in late adolescence. BMJ. 1991 May 25;302(6787):1235–1237. doi: 10.1136/bmj.302.6787.1235. [DOI] [PMC free article] [PubMed] [Google Scholar]
  64. Stavola B. L., Hardy R., Kuh D., Silva I. S., Wadsworth M., Swerdlow A. J. Birthweight, childhood growth and risk of breast cancer in a British cohort. Br J Cancer. 2000 Oct;83(7):964–968. doi: 10.1054/bjoc.2000.1370. [DOI] [PMC free article] [PubMed] [Google Scholar]
  65. Stein Aryeh D., Conlisk Andrea, Torun Benjamin, Schroeder Dirk G., Grajeda Ruben, Martorell Reynaldo. Cardiovascular disease risk factors are related to adult adiposity but not birth weight in young guatemalan adults. J Nutr. 2002 Aug;132(8):2208–2214. doi: 10.1093/jn/132.8.2208. [DOI] [PubMed] [Google Scholar]
  66. Stettler Nicolas, Zemel Babette S., Kumanyika Shiriki, Stallings Virginia A. Infant weight gain and childhood overweight status in a multicenter, cohort study. Pediatrics. 2002 Feb;109(2):194–199. doi: 10.1542/peds.109.2.194. [DOI] [PubMed] [Google Scholar]
  67. Sørensen H. T., Sabroe S., Rothman K. J., Gillman M., Fischer P., Sørensen T. I. Relation between weight and length at birth and body mass index in young adulthood: cohort study. BMJ. 1997 Nov 1;315(7116):1137–1137. doi: 10.1136/bmj.315.7116.1137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  68. Tibblin G., Eriksson M., Cnattingius S., Ekbom A. High birthweight as a predictor of prostate cancer risk. Epidemiology. 1995 Jul;6(4):423–424. doi: 10.1097/00001648-199507000-00017. [DOI] [PubMed] [Google Scholar]
  69. Ulizzi L. Absence of selection on birth weight in modern Italy. Hum Biol. 2002 Aug;74(4):525–532. doi: 10.1353/hub.2002.0048. [DOI] [PubMed] [Google Scholar]
  70. Vanhala M. J., Vanhala P. T., Keinänen-Kiukaanniemi S. M., Kumpusalo E. A., Takala J. K. Relative weight gain and obesity as a child predict metabolic syndrome as an adult. Int J Obes Relat Metab Disord. 1999 Jun;23(6):656–659. doi: 10.1038/sj.ijo.0800898. [DOI] [PubMed] [Google Scholar]
  71. Vågerö D., Leon D. Ischaemic heart disease and low birth weight: a test of the fetal-origins hypothesis from the Swedish Twin Registry. Lancet. 1994 Jan 29;343(8892):260–263. doi: 10.1016/s0140-6736(94)91112-6. [DOI] [PubMed] [Google Scholar]
  72. Walker A. R., Walker B. F., Glatthaar I. I. Is the lesser growth of African schoolchildren essentially prejudicial to their present and future health? Trop Geogr Med. 1995;47(4):145–150. [PubMed] [Google Scholar]
  73. Wannamethee S. Goya, Shaper A. Gerald, Whincup Peter H., Walker Mary. Migration within Great Britain and cardiovascular disease: early life and adult environmental factors. Int J Epidemiol. 2002 Oct;31(5):1054–1060. doi: 10.1093/ije/31.5.1054. [DOI] [PubMed] [Google Scholar]
  74. Wilcox A. J. On the importance--and the unimportance--of birthweight. Int J Epidemiol. 2001 Dec;30(6):1233–1241. doi: 10.1093/ije/30.6.1233. [DOI] [PubMed] [Google Scholar]
  75. Williams S., Poulton R. Twins and maternal smoking: ordeals for the fetal origins hypothesis? A cohort study. BMJ. 1999 Apr 3;318(7188):897–900. doi: 10.1136/bmj.318.7188.897. [DOI] [PMC free article] [PubMed] [Google Scholar]
  76. Wollschlaeger K., Nieder J., Köppe I., Härtlein K. A study of fetal macrosomia. Arch Gynecol Obstet. 1999 Nov;263(1-2):51–55. doi: 10.1007/s004040050262. [DOI] [PubMed] [Google Scholar]
  77. Yajnik C. S. The insulin resistance epidemic in India: fetal origins, later lifestyle, or both? Nutr Rev. 2001 Jan;59(1 Pt 1):1–9. doi: 10.1111/j.1753-4887.2001.tb01898.x. [DOI] [PubMed] [Google Scholar]
  78. Yeazel M. W., Ross J. A., Buckley J. D., Woods W. G., Ruccione K., Robison L. L. High birth weight and risk of specific childhood cancers: a report from the Children's Cancer Group. J Pediatr. 1997 Nov;131(5):671–677. doi: 10.1016/s0022-3476(97)70091-x. [DOI] [PubMed] [Google Scholar]

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