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. 1988 Aug;56(8):2011–2015. doi: 10.1128/iai.56.8.2011-2015.1988

Prevention by gamma interferon of fatal infection with Listeria monocytogenes in mice treated with cyclosporin A.

A Nakane 1, T Minagawa 1, I Yasuda 1, C Yu 1, K Kato 1
PMCID: PMC259516  PMID: 3135267

Abstract

The significance of interferons (IFNs) induced by Listeria monocytogenes in the antilisterial defense mechanism was studied in mice. Cyclosporin A (CsA) had no effect on IFN-alpha production that was induced in the bloodstream after intravenous infection of mice with L. monocytogenes, whereas IFN-gamma that was induced in the bloodstreams of control mice 6 h after stimulation with specific antigen in the late phase of infection was suppressed in CsA-treated mice, depending on the dose of the drug injected. The decrease in IFN-gamma production caused an increase in bacterial growth in the spleens and livers of CsA-treated mice. Furthermore, administration of a daily dose of CsA at 80 or 100 mg/kg of body weight resulted in fatal listeriosis, even though the dose was nonlethal for normal mice. The administration of recombinant murine IFN-gamma on day 0 of L. monocytogenes infection prevented CsA-treated mice from developing fatal listeriosis and restored their ability to produce IFN-gamma in the bloodstream, in response to specific antigen in the late phase of infection.

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2011

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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