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. 1976 Mar;49(1):83–91.

Cytomegalovirus Infection in Children Undergoing Open-Heart Surgery 1

John A Armstrong, George C Tarr, Leona A Youngblood, John N Dowling, Arnold R Saslow, John P Lucas, Monto Ho
PMCID: PMC2595348  PMID: 183389

Abstract

A group of 124 children undergoing open-heart surgery was followed prospectively in order to estimate the risk of cytomegalovirus (CMV) infection due to transfused blood.

Ninety-three patients (75%) had complement fixation (CF) titers of < 1:4 against CMV on admission. Of this seronegative subgroup, nine patients (9.7%) subsequently became infected with CMV. All nine showed seroconversion, and six were viruric 12-14 weeks after surgery. Comparative seroepidemiological studies of the hospital population showed that in the age ranges studied (3-16 yr), the infections seen in the study group represented a significant excess over expectation. This infection rate was consistent with a model of transmission by blood transfusion with a risk of 2.7% per unit but not proven.

Thirty-one patients had CF antibody to CMV on admission. CMV was isolated from 14% of urines of seropositive children both before and after surgery, but only two patients showed CF antibody rises to CMV. Thus the frequency of CMV infection associated with open-heart surgery and transfusion could not be calculated in the seropositive subgroup.

CMV infection was not related to the primary diagnosis or to Down's syndrome.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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