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. 1977 Jul-Aug;50(4):419–427.

Transient Warm Autoimmune Hemolytic Anemia and Cryoglobulinemia Associated with Seminoma

W Bruce Lundberg, Malcolm S Mitchell
PMCID: PMC2595514  PMID: 906560

Abstract

A patient with a pure seminoma presented with severe IgG-mediated warm autoimmune hemolytic anemia. Monoclonal IgM-kappa cryoglobulinemia and a biological false positive test for syphilis were also found. Treatment directed at both the seminoma and the hemolysis resulted in the complete disappearance of these antibodies. It is possible that these immunological phenomena occurred in response to the tumor. The occurrence of warm autoimmune hemolytic anemia and monoclonal paraproteinemia in association with solid tumors is reviewed.

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Selected References

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  1. ALLIBONE E. C., COLLINS D. H. Symptomatic haemolytic anaemia associated with ovarian teratoma in child. J Clin Pathol. 1951 Nov;4(4):412–420. doi: 10.1136/jcp.4.4.412. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Alexanian R. Monoclonal gammopathy in lymphoma. Arch Intern Med. 1975 Jan;135(1):62–66. [PubMed] [Google Scholar]
  3. André R., Duhamel G., Najman A., Homberg J. C., Mawas C., Armangol R. Anémie hémolytique auto-immune et tumeur maligne de l'ovarie. Presse Med. 1969 Dec 27;77(56):2133–2136. [PubMed] [Google Scholar]
  4. BARRY K. G., CROSBY W. H. Auto-immune hemolytic anemia arrested by removal of an ovarian teratoma: review of the literature and report of a case. Ann Intern Med. 1957 Nov;47(5):1002–1007. doi: 10.7326/0003-4819-47-5-1002. [DOI] [PubMed] [Google Scholar]
  5. BOHROD M. G. Plasmacytosis and cryoglobulinemia in cancer. J Am Med Assoc. 1957 May 4;164(1):18–21. doi: 10.1001/jama.1957.02980010020005. [DOI] [PubMed] [Google Scholar]
  6. BRAIN M. C., DACIE J. V., HOURIHANE D. O. Microangiopathic haemolytic anaemia: the possible role of vascular lesions in pathogenesis. Br J Haematol. 1962 Oct;8:358–374. doi: 10.1111/j.1365-2141.1962.tb06541.x. [DOI] [PubMed] [Google Scholar]
  7. Baker L. R., Brain M. C., Azzopardi J. G., Worlledge S. M. Autoimmune haemolytic anaemia associated with ovarian dermoid cyst. J Clin Pathol. 1968 Sep;21(5):626–630. doi: 10.1136/jcp.21.5.626. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Bohnen R. F., Ultmann J. E., Gorman J. G., Farhangi M., Scudder J. The direct Coombs' test: its clinical significance. Study in a large university hospital. Ann Intern Med. 1968 Jan;68(1):19–32. doi: 10.7326/0003-4819-68-1-19. [DOI] [PubMed] [Google Scholar]
  9. Brain M. C., Azzopardi J. G., Baker L. R., Pineo G. F., Roberts P. D., Dacie J. V. Microangiopathic haemolytic anaemia and mucin-forming adenocarcinoma. Br J Haematol. 1970 Feb;18(2):183–193. doi: 10.1111/j.1365-2141.1970.tb01433.x. [DOI] [PubMed] [Google Scholar]
  10. Brouet J. C., Clauvel J. P., Danon F., Klein M., Seligmann M. Biologic and clinical significance of cryoglobulins. A report of 86 cases. Am J Med. 1974 Nov;57(5):775–788. doi: 10.1016/0002-9343(74)90852-3. [DOI] [PubMed] [Google Scholar]
  11. Burkert L., Becker G., Pisciotta A. V. Ovarian malignancy and hemolytic anemia. Demonstration of a hemolytic serum factor. Ann Intern Med. 1970 Jul;73(1):91–93. doi: 10.7326/0003-4819-73-1-91. [DOI] [PubMed] [Google Scholar]
  12. Dacie J. V. Autoimmune hemolytic anemia. Arch Intern Med. 1975 Oct;135(10):1293–1300. [PubMed] [Google Scholar]
  13. Dawson M. A., Talbert W., Yarbro J. W. Hemolytic anemia associated with an ovarian tumor. Am J Med. 1971 Apr;50(4):552–556. doi: 10.1016/0002-9343(71)90345-7. [DOI] [PubMed] [Google Scholar]
  14. De Bruyère M., Sokal G., Devoitille J. M., Fauchet-Dutrieux M. C., De Spa V. Autoimmune haemolytic anaemia and ovarian tumour. Br J Haematol. 1971 Jan;20(1):83–94. doi: 10.1111/j.1365-2141.1971.tb00789.x. [DOI] [PubMed] [Google Scholar]
  15. ELLIS L. D., WESTERMAN M. P. AUTOIMMUNE HEMOLYTIC ANEMIA AND CANCER. JAMA. 1965 Sep 13;193:962–964. doi: 10.1001/jama.1965.03090110100033. [DOI] [PubMed] [Google Scholar]
  16. FRUMIN A. M., MENDELL T. H., MERANZE D. R. Hematologic manifestations of metastatic gastric malignancy. Gastroenterology. 1954 Aug;27(2):183–188. [PubMed] [Google Scholar]
  17. Friou G. J. Current knowledge and concepts of the relationship of malignancy, autoimmunity, and immunologic disease. Ann N Y Acad Sci. 1974;230:23–55. doi: 10.1111/j.1749-6632.1974.tb14436.x. [DOI] [PubMed] [Google Scholar]
  18. GREEN H. N., WAKEFIELD J., LITTLEWOOD G. The nature of cancer anaemia and its bearing on the immunological theory of cancer. Br Med J. 1957 Oct 5;2(5048):779–784. doi: 10.1136/bmj.2.5048.779. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Giesy J. D., Pirofsky B., Hodges C. V. Positive antiglobulin reactions complicating urological surgery. J Urol. 1966 Jun;95(6):809–813. doi: 10.1016/S0022-5347(17)63548-1. [DOI] [PubMed] [Google Scholar]
  20. HYMAN G. A., GELLHORN A., HARVEY J. L. Studies on the anemia of disseminated malignant neoplastic disease. II. Study of the life span of the erythrocyte. Blood. 1956 Jul;11(7):618–631. [PubMed] [Google Scholar]
  21. HYMAN G. A., HARVEY J. E. The pathogenesis of anemia in patients with carcinoma. Am J Med. 1955 Sep;19(3):350–356. doi: 10.1016/0002-9343(55)90123-6. [DOI] [PubMed] [Google Scholar]
  22. Harker L. A., Slichter S. J. Platelet and fibrinogen consumption in man. N Engl J Med. 1972 Nov 16;287(20):999–1005. doi: 10.1056/NEJM197211162872001. [DOI] [PubMed] [Google Scholar]
  23. Lalezari P. Serologic profile in autoimmune hemolytic disease: pathophysiologic and clinical interpretations. Semin Hematol. 1976 Oct;13(4):291–310. [PubMed] [Google Scholar]
  24. Lohrmann H. P., Adam W., Heymer B., Kubanek B. Microangiopathic hemolytic anemia in metastatic carcinoma. Report of eight cases. Ann Intern Med. 1973 Sep;79(3):368–375. doi: 10.7326/0003-4819-79-3-368. [DOI] [PubMed] [Google Scholar]
  25. MCANDREW G. M. HAEMOLYTIC ANAEMIA ASSOCIATED WITH OVARIAN TERATOMA. Br Med J. 1964 Nov 21;2(5420):1307–1308. doi: 10.1136/bmj.2.5420.1307. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Michaux J. L., Heremans J. F. Thirty cases of monoclonal immunoglobulin disorders other than myeloma or macroglobulinemia. A classification of diseases associated with the production of monoclonal-type immunoglobulins. Am J Med. 1969 Apr;46(4):562–579. doi: 10.1016/0002-9343(69)90075-8. [DOI] [PubMed] [Google Scholar]
  27. Migliore P. J., Alexanian R. Monoclonal gammopathy in human neoplasia. Cancer. 1968 Jun;21(6):1127–1131. doi: 10.1002/1097-0142(196806)21:6<1127::aid-cncr2820210613>3.0.co;2-0. [DOI] [PubMed] [Google Scholar]
  28. Miura A. B., Shibata A., Akihama T., Endo Y., Sugawara M. Autoimmune hemolytic anemia associated with colon cancer. Cancer. 1974 Jan;33(1):111–114. doi: 10.1002/1097-0142(197401)33:1<111::aid-cncr2820330117>3.0.co;2-9. [DOI] [PubMed] [Google Scholar]
  29. NORCROSS J. W. Hematologic manifestations of malignant disease. Med Clin North Am. 1963 Mar;47:345–352. doi: 10.1016/s0025-7125(16)33592-1. [DOI] [PubMed] [Google Scholar]
  30. OSSERMAN E. F., TAKATSUKI K. PLASMA CELL MYELOMA: GAMMA GLOBULIN SYNTHESIS AND STRUCTURE. A REVIEW OF BIOCHEMICAL AND CLINICAL DATA, WITH THE DESCRIPTION OF A NEWLY-RECOGNIZED AND RELATED SYNDROME, "H-GAMMA-2-CHAIN (FRANKLIN'S) DISEASE. Medicine (Baltimore) 1963 Nov;42:357–384. [PubMed] [Google Scholar]
  31. Pirofsky B. Autoimmune hemolytic anemia and neoplasia of the reticuloendothelium. With a hypothesis concerning etiologic relationships. Ann Intern Med. 1968 Jan;68(1):109–121. doi: 10.7326/0003-4819-68-1-109. [DOI] [PubMed] [Google Scholar]
  32. SHEN S. C., HOMBURGER F. The anemia of cancer patients and its relation to metastases to the bone marrow. J Lab Clin Med. 1951 Feb;37(2):182–198. [PubMed] [Google Scholar]
  33. SOHIER W. D., Jr, JURANIES E., AUB J. C. Hemolytic anemia, a host response to malignancy. Cancer Res. 1957 Sep;17(8):767–774. [PubMed] [Google Scholar]
  34. Waldmann T. A., Durm M., Broder S., Blackman M., Blaese R. M., Strober W. Role of suppressor T cells in pathogenesis of common variable hypogammaglobulinaemia. Lancet. 1974 Sep 14;2(7881):609–613. doi: 10.1016/s0140-6736(74)91940-0. [DOI] [PubMed] [Google Scholar]
  35. West-Watson W. N., Young C. J. Failed Splenectomy in Acholuric Jaundice. Br Med J. 1938 Jun 18;1(4041):1305–1309. doi: 10.1136/bmj.1.4041.1305. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Yam L. T., Rudzki C., Busch S., Leithold S. L. Ovarian neoplasm associated with autoimmune hemolytic anemia. Am J Obstet Gynecol. 1966 May 15;95(2):207–211. doi: 10.1016/0002-9378(66)90170-0. [DOI] [PubMed] [Google Scholar]

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