Abstract
Five patients seen during a two-month period who developed untoward systemic reactions following high dose intravenous administration of nafcillin are described. Recovery was complete upon discontinuation of the drug. The clustering of these cases and the high incidence (5 of 5) of side effects are highly unusual, and suggest that the frequency of nafcillin reactions might be higher than previously suspected.
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Selected References
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- Ahern M. J., Hicks J. E., Andriole V. T. Neutropenia during high dose intravenous oxacillin therapy. Yale J Biol Med. 1976 Sep;49(4):351–360. [PMC free article] [PubMed] [Google Scholar]
- Baldwin D. S., Levine B. B., McCluskey R. T., Gallo G. R. Renal failure and interstitial nephritis due to penicillin and methicillin. N Engl J Med. 1968 Dec 5;279(23):1245–1252. doi: 10.1056/NEJM196812052792302. [DOI] [PubMed] [Google Scholar]
- Border W. A., Lehman D. H., Egan J. D., Sass H. J., Glode J. E., Wilson C. B. Antitubular basement-membrane antibodies in methicillin-associated interstitial nephritis. N Engl J Med. 1974 Aug 22;291(8):381–384. doi: 10.1056/NEJM197408222910803. [DOI] [PubMed] [Google Scholar]
- Dismukes W. E. Oxacillin-induced hepatic dysfunction. JAMA. 1973 Nov 19;226(8):861–863. [PubMed] [Google Scholar]
- FREEDMAN M. A. OXACILLIN--APPARENT HEMATOLOGIC AND HEPATIC TOXICITY. Rocky Mt Med J. 1965 Jan;62:34–36. [PubMed] [Google Scholar]
- Gilbert D. N., Sanford J. P. Methicillin: critical appraisal after a decade of experience. Med Clin North Am. 1970 Sep;54(5):1113–1125. [PubMed] [Google Scholar]
- Glew R. H., Millering R. S., Jr, Wennersten C. Comparative synergistic activity of nafcillin, oxacillin, and methicillin in combination with gentamicin against. Antimicrob Agents Chemother. 1975 Jun;7(6):828–832. doi: 10.1128/aac.7.6.828. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Idsoe O., Guthe T., Willcox R. R., de Weck A. L. Nature and extent of penicillin side-reactions, with particular reference to fatalities from anaphylactic shock. Bull World Health Organ. 1968;38(2):159–188. [PMC free article] [PubMed] [Google Scholar]
- LEVITT B. H., GOTTLIEB A. J., ROSENBERG I. R., KLEIN J. J. BONE MARROW DEPRESSION DUE TO METHICILLIN, A SEMISYNTHETIC PENICILLIN. Clin Pharmacol Ther. 1964 May-Jun;5:301–306. doi: 10.1002/cpt196453301. [DOI] [PubMed] [Google Scholar]
- MARTIN C. M. CLINICAL STATUS OF NAFCILLIN. Antimicrob Agents Chemother (Bethesda) 1964;10:285–291. [PubMed] [Google Scholar]
- Markowitz S. M., Rothkopf M., Holden F. D., Stith D. M., Duma R. J. Nafcillin-induced agranulocytosis. JAMA. 1975 Jun 16;232(11):1150–1152. [PubMed] [Google Scholar]
- Sandberg M., Tuazon C. U., Sheagren J. N. Neutropenia probably resulting from nafcillin. JAMA. 1975 Jun 16;232(11):1152–1154. [PubMed] [Google Scholar]
- Weitzman S. A., Stossel T. P. Drug-induced immunological neutropenia. Lancet. 1978 May 20;1(8073):1068–1072. doi: 10.1016/s0140-6736(78)90915-7. [DOI] [PubMed] [Google Scholar]
