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. 1988 Sep;56(9):2369–2372. doi: 10.1128/iai.56.9.2369-2372.1988

Use of lymphokines in treatment of experimental intra-abdominal abscess caused by Bacteroides fragilis.

S V Gollapudi 1, A Gupta 1, H Thadepalli 1, A Perez 1
PMCID: PMC259574  PMID: 3044996

Abstract

The role of cell-free soluble factors (lymphokines) derived from mitogen-activated splenic cells of mice previously immunized against Bacteroides fragilis was evaluated in the treatment of B. fragilis intra-abdominal abscess (IAA). Neither clindamycin nor lymphokines alone were effective against an established B. fragilis IAA, but the combination of clindamycin and lymphokines decreased the abscess size and bacterial counts in the majority of animals. This suggests that the synergy of lymphokines with clindamycin effects cure of IAA caused by B. fragilis and that lymphokines might have an application as adjuncts to conventional antimicrobial therapy in this setting.

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Selected References

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