Skip to main content
The Yale Journal of Biology and Medicine logoLink to The Yale Journal of Biology and Medicine
. 1980 Jul-Aug;53(4):325–332.

Truth and fancy in the management of the solitary thyroid nodule.

G N Burrow
PMCID: PMC2595823  PMID: 7445539

Abstract

Although there is considerable controversy about the proper management of the solitary nodule, certain information may be useful in reaching this decision. Age, sex, and a previous history of external irradiation to the head and neck are helpful as are the clinical characteristics of the thyroid gland. Whether the nodule is functioning or "cold" on thyroid scan, and cystic or solid on thyroid ultrasound is also helpful. Based on these findings, the physician must decide whether to recommend surgery or thyroid hormone suppressive therapy.

Full text

PDF
325

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BOWENS O. M., VANDER J. B. Thyroid nodules and thyroid malignancy. The risk involved in delayed surgery. Ann Intern Med. 1962 Aug;57:245–253. doi: 10.7326/0003-4819-57-2-245. [DOI] [PubMed] [Google Scholar]
  2. Blum M. Enhanced clinical diagnosis of thyroid disease using echography. Am J Med. 1975 Sep;59(3):301–307. doi: 10.1016/0002-9343(75)90387-3. [DOI] [PubMed] [Google Scholar]
  3. Burrow G. N., Mujtaba Q., LiVolsi V., Cornog J. The incidence of carcinoma in solitary "cold" thyroid nodules. Yale J Biol Med. 1978 Jan-Feb;51(1):13–17. [PMC free article] [PubMed] [Google Scholar]
  4. DUFFY B. J., Jr, FITZGERALD P. J. Cancer of the thyroid in children: a report of 28 cases. J Clin Endocrinol Metab. 1950 Oct;10(10):1296–1308. doi: 10.1210/jcem-10-10-1296. [DOI] [PubMed] [Google Scholar]
  5. Field J. B., Larsen P. R., Yamashita K., Mashiter K., Dekker A. Demonstration of iodide transport defect but normal iodide organification in nonfunctioning nodules of human thyroid glands. J Clin Invest. 1973 Oct;52(10):2404–2410. doi: 10.1172/JCI107430. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Kirkland R. T., Kirkland J. L., Rosenberg H. S., Harberg F. J., Librik L., Clayton G. W. Solitary thyroid nodules in 30 children and report of a child with a thyroid abscess. Pediatrics. 1973 Jan;51(1):85–90. [PubMed] [Google Scholar]
  7. Miller J. M., Hamburger J. I., Mellinger R. C. The thyroid scintigram. II. The cold nodule. Radiology. 1965 Oct;85(4):702–710. doi: 10.1148/85.4.702. [DOI] [PubMed] [Google Scholar]
  8. Miller J. M., Zafar S. U., Karo J. J. The cystic thyroid nodule. Recognition and management. Radiology. 1974 Feb;110(2):257–261. doi: 10.1148/110.2.257. [DOI] [PubMed] [Google Scholar]
  9. Rallison M. L., Dobyns B. M., Keating F. R., Jr, Rall J. E., Tyler F. H. Thyroid nodularity in children. JAMA. 1975 Sep 8;233(10):1069–1072. [PubMed] [Google Scholar]
  10. Refetoff S., Harrison J., Karanfilski B. T., Kaplan E. L., De Groot L. J., Bekerman C. Continuing occurrence of thyroid carcinoma after irradiation to the neck in infancy and childhood. N Engl J Med. 1975 Jan 23;292(4):171–175. doi: 10.1056/NEJM197501232920402. [DOI] [PubMed] [Google Scholar]
  11. Shimaoka K., Sokal J. E. Suppressive therapy of nontoxic goiter. Am J Med. 1974 Oct;57(4):576–583. doi: 10.1016/0002-9343(74)90009-6. [DOI] [PubMed] [Google Scholar]
  12. WINSHIP T., ROSVOLL R. V. Childhood thyroid carcinoma. Cancer. 1961 Jul-Aug;14:734–743. doi: 10.1002/1097-0142(199007/08)14:4<734::aid-cncr2820140410>3.0.co;2-w. [DOI] [PubMed] [Google Scholar]

Articles from The Yale Journal of Biology and Medicine are provided here courtesy of Yale Journal of Biology and Medicine

RESOURCES