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. 1980 Jan-Feb;53(1):47–54.

Herpes simplex virus infection: problems and prospects as perceived by a peripatetic pediatrician.

A J Nahmias
PMCID: PMC2595848  PMID: 6246686

Abstract

The multivaried aspects of the herpes simplex viruses (HSV) types 1 and 2 and the infections they produce are discussed. Points emphasized are: (1) the need for considering these (and other viruses) from an evolutionary perspective; (2) the necessity of disseminating current methods for virus identification; (3) the great progress in molecular-virological aspects and in the genetics of the virus which provide new tools for epidemiological and immunological studies and define more convincingly the possible causal role of HSV-2 in cervical carcinogenesis; (4) the problems with vaccines and the therapeutic advances and failures; (5) the great psychosocial aspect of some herpetic infections and the need to be sympathetic and supportive to afflicted patients and their families; (6) the overreaction regarding HSV that currently exists among physicians, nurses, the public, and the press resulting in increased misery for those afflicted or misdiagnosed, or in poor advice or management given by some physicians pressured in part by the fear of malpractice suits. The problems then are many but the prospects for their solution are in sight as more research at all levels is being conducted today in all corners of the world on the complex herpes simplex viruses.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aurelian L., Davis H. J., Julian C. G. Herpesvirus type 2-induced, tumor-specific antigen in cervical carcinoma. Am J Epidemiol. 1973 Jul;98(1):1–9. doi: 10.1093/oxfordjournals.aje.a121527. [DOI] [PubMed] [Google Scholar]
  2. Baringer J. R. Herpes simplex virus infection of nervous tissue in animals and man. Prog Med Virol. 1975;20:1–26. [PubMed] [Google Scholar]
  3. Buchman T. G., Roizman B., Nahmias A. J. Demonstration of exogenous genital reinfection with herpes simplex virus type 2 by restriction endonuclease fingerprinting of viral DNA. J Infect Dis. 1979 Sep;140(3):295–304. doi: 10.1093/infdis/140.3.295. [DOI] [PubMed] [Google Scholar]
  4. Camacho A., Spear G. Transformation of hamster embryo fibroblasts by a specific fragment of the herpes simplex virus genome. Cell. 1978 Nov;15(3):993–1002. doi: 10.1016/0092-8674(78)90283-0. [DOI] [PubMed] [Google Scholar]
  5. Ching C., Lopez C. Natural killing of herpes simplex virus type 1-infected target cells: normal human responses and influence of antiviral antibody. Infect Immun. 1979 Oct;26(1):49–56. doi: 10.1128/iai.26.1.49-56.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Nahmias A. J., Alford C. A., Korones S. B. Infection of the newborn with herpesvirus hominis. Adv Pediatr. 1970;17:185–226. [PubMed] [Google Scholar]
  7. Nahmias A. J. Herpesviruses from fish to man--a search for pathobiologic unity. Pathobiol Annu. 1972;2:153–182. [PubMed] [Google Scholar]
  8. Nahmias A. J., Sawanabori S. The genital herpes-cervical cancer hypothesis--10 years later. Prog Exp Tumor Res. 1978;21:117–139. doi: 10.1159/000400861. [DOI] [PubMed] [Google Scholar]
  9. Naib Z. M., Nahmias A. J., Josey W. E. Cytology and histopathology of cervical herpes simplex infection. Cancer. 1966 Jul;19(7):1026–1031. doi: 10.1002/1097-0142(196607)19:7<1026::aid-cncr2820190718>3.0.co;2-#. [DOI] [PubMed] [Google Scholar]
  10. Roizman B., Buchman T. The molecular epidemiology of herpes simplex viruses. Hosp Pract. 1979 Jan;14(1):95–104. doi: 10.1080/21548331.1979.11707470. [DOI] [PubMed] [Google Scholar]
  11. Roizman B. The structure and isomerization of herpes simplex virus genomes. Cell. 1979 Mar;16(3):481–494. doi: 10.1016/0092-8674(79)90023-0. [DOI] [PubMed] [Google Scholar]
  12. Skinner G. R., Whitney J. E., Hartley C. Prevalence of type-specific antibody against type 1 and type 2 herpes simplex virus in women with abnormal cervical cytology: evidence towards pre-pubertal vaccination of sero-negative female subjects. Arch Virol. 1977;54(3):211–221. doi: 10.1007/BF01314787. [DOI] [PubMed] [Google Scholar]
  13. Warren K. G., Brown S. M., Wroblewska Z., Gilden D., Koprowski H., Subak-Sharpe J. Isolation of latent herpes simplex virus from the superior cervical and vagus ganglions of human beings. N Engl J Med. 1978 May 11;298(19):1068–1069. doi: 10.1056/NEJM197805112981907. [DOI] [PubMed] [Google Scholar]
  14. Wentz W. B., Reagan J. W., Heggie A. D. Cervical carcinogenesis with herpes simplex virus, type 2. Obstet Gynecol. 1975 Aug;46(2):117–121. [PubMed] [Google Scholar]
  15. Whitley R. J., Soong S. J., Dolin R., Galasso G. J., Ch'ien L. T., Alford C. A. Adenine arabinoside therapy of biopsy-proved herpes simplex encephalitis. National Institute of Allergy and Infectious Diseases collaborative antiviral study. N Engl J Med. 1977 Aug 11;297(6):289–294. doi: 10.1056/NEJM197708112970601. [DOI] [PubMed] [Google Scholar]

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