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. 1981 Mar-Apr;54(2):111–125.

Neoplasms in domestic animals: a review of experimental and spontaneous carcinogenesis.

B R Madewell
PMCID: PMC2595863  PMID: 7269640

Abstract

Clues to environmental and host factors in human oncogenesis are derived from clinical or epidemiologic studies; additional evidence is provided by animal experimentation. Induced tumors in animals are useful because of their reproducibility and predictability, allowing detailed study of specific carcinogens or carcinogenic influences. Spontaneously or naturally occurring tumors in domestic animals are of particular interest for comparative studies - these tumors occur in heterogenous outbred populations of animal closely sharing man's environment; their cause is generally unknown; many tumors occur in numbers suitable for detailed investigations; and tumors generally occur in aged animals, thus facilitating study of chronic processes associated with carcinogenesis in nature.

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Selected References

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  1. ALLISON J. B., WASE A. W., LEATHEM J. H., WAINIO W. W. Some effects of 2-acetylaminofluorene on the dog. Cancer Res. 1950 May;10(5):266–271. [PubMed] [Google Scholar]
  2. Auerbach O., Hammond E. C., Kirman D., Garfinkel L. Effects of cigarette smoking on dogs. II. Pulmonary neoplasms. Arch Environ Health. 1970 Dec;21(6):754–768. doi: 10.1080/00039896.1970.10667329. [DOI] [PubMed] [Google Scholar]
  3. BAILEY W. S. PARASITES AND CANCER: SARCOMA IN DOGS ASSOCIATED WITH SPIROCERCA LUPI. Ann N Y Acad Sci. 1963 Nov 4;108:890–923. doi: 10.1111/j.1749-6632.1963.tb13429.x. [DOI] [PubMed] [Google Scholar]
  4. Bech-Nielsen S., Haskins M. E., Reif J. S., Brodey R. S., Patterson D. F., Spielman R. Frequency of osteosarcoma among first-degree relatives of St. Bernard dogs. J Natl Cancer Inst. 1978 Feb;60(2):349–353. doi: 10.1093/jnci/60.2.349. [DOI] [PubMed] [Google Scholar]
  5. Benjamin S. A., Boecker B. B., Cuddihy R. G., McClellan R. O. Nasal carcinomas in beagles after inhalation of relatively soluble forms of beta-emitting radionuclides. J Natl Cancer Inst. 1979 Jul;63(1):133–139. [PubMed] [Google Scholar]
  6. Benjamin S. A., Hahn F. F., Chieffelle T. L., Boecker B. B., Hobbs C. H. Occurrence of hemangiosarcomas in beagles with internally deposited radionuclides. Cancer Res. 1975 Jul;35(7):1745–1755. [PubMed] [Google Scholar]
  7. Bingel S. A., Brodey R. S., Allen H. L., Riser W. H. Haemangiosarcoma of bone in the dog. J Small Anim Pract. 1974 May;15(5):303–322. doi: 10.1111/j.1748-5827.1974.tb05698.x. [DOI] [PubMed] [Google Scholar]
  8. Black H. E., Capen C. C., Young D. M. Ultimobranchial thyroid neoplasms in bulls. A syndrome resembling medullary thyroid carcinoma in man. Cancer. 1973 Oct;32(4):865–878. doi: 10.1002/1097-0142(197310)32:4<865::aid-cncr2820320418>3.0.co;2-t. [DOI] [PubMed] [Google Scholar]
  9. Brodey R. S., Craig P. H. Primary pulmonary neoplasms in the dog: a review of 29 cases. J Am Vet Med Assoc. 1965 Dec 15;147(12):1628–1643. [PubMed] [Google Scholar]
  10. Brodey R. S., Misdorp W., Riser W. H., van der Heul R. O. Canine skeletal chondrosarcoma: a clinicopathologic study of 35 cases. J Am Vet Med Assoc. 1974 Jul 1;165(1):68–78. [PubMed] [Google Scholar]
  11. Burridge M. J., Wilcox C. J., Hennemann J. M. Influence of genetic factors on the susceptibility of cattle to bovine leukemia virus infection. Eur J Cancer. 1979 Nov;15(11):1395–1400. doi: 10.1016/0014-2964(79)90117-8. [DOI] [PubMed] [Google Scholar]
  12. CHANG H. P. HEPATIC CLONORCHIASIS AND CARCINOMA OF THE BILE DUCT IN A DOG. J Pathol Bacteriol. 1965 Jan;89:365–367. [PubMed] [Google Scholar]
  13. COPLAN M. M. Report on carcinogenic action of certain agents on urinary bladder of dogs. J Am Med Assoc. 1960 Apr 9;172:1611–1618. doi: 10.1001/jama.1960.03020150035007. [DOI] [PubMed] [Google Scholar]
  14. Cameron A. M., Faulkin L. J., Jr Hyperplastic and inflammatory nodules in the canine mammary gland. J Natl Cancer Inst. 1971 Dec;47(6):1277–1287. [PubMed] [Google Scholar]
  15. Cohen D. In vitro cell-mediated cytotoxicity and antibody-dependent cellular cytotoxicity to the transmissible venereal tumor of the dog. J Natl Cancer Inst. 1980 Feb;64(2):317–321. doi: 10.1093/jnci/64.2.317. [DOI] [PubMed] [Google Scholar]
  16. Dorn C. R., Priester W. A. Epidemiologic analysis of oral and pharyngeal cancer in dogs, cats, horses, and cattle. J Am Vet Med Assoc. 1976 Dec 1;169(11):1202–1206. [PubMed] [Google Scholar]
  17. Dorn C. R., Taylor D. O., Schneider R., Hibbard H. H., Klauber M. R. Survey of animal neoplasms in Alameda and Contra Costa Counties, California. II. Cancer morbidity in dogs and cats from Alameda County. J Natl Cancer Inst. 1968 Feb;40(2):307–318. [PubMed] [Google Scholar]
  18. Dorn C. R., Taylor D. O., Schneider R. Sunlight exposure and risk of developing cutaneous and oral squamous cell carcinomas in white cats. J Natl Cancer Inst. 1971 May;46(5):1073–1078. [PubMed] [Google Scholar]
  19. Duncan J. R., Tyler D. E., Van Der Maaten M. J., Andersen J. R. Enzootic nasal adenocarcinoma in sheep. J Am Vet Med Assoc. 1967 Sep 15;151(6):732–734. [PubMed] [Google Scholar]
  20. Edwards C., Heath D., Harris P., Castillo Y., Krüger H., Arias-Stella J. The carotid body in animals at high altitude. J Pathol. 1971 Aug;104(4):231–238. doi: 10.1002/path.1711040404. [DOI] [PubMed] [Google Scholar]
  21. El Etreby M. F., Müller-Peddinghaus R., Bhargava A. S., El Bab M. R., Gräf K. J., Trautwein G. The role of the pituitary gland in spontaneous canine mammary tumorigenesis. Vet Pathol. 1980 Jan;17(1):2–16. doi: 10.1177/030098588001700101. [DOI] [PubMed] [Google Scholar]
  22. El Etreby M. F., Müller-Peddinghaus R., Bhargava A. S., Trautwein G. Functional morphology of spontaneous hyperplastic and neoplastic lesions in the canine pituitary gland. Vet Pathol. 1980 Mar;17(2):109–122. doi: 10.1177/030098588001700201. [DOI] [PubMed] [Google Scholar]
  23. FORTNER J. G., LEFFALL L. D. Carcinoma of the gallbladder in dogs. Cancer. 1961 Sep-Oct;14:1127–1130. doi: 10.1002/1097-0142(196109/10)14:5<1127::aid-cncr2820140535>3.0.co;2-m. [DOI] [PubMed] [Google Scholar]
  24. Fiala S., Fiala A. E., Dixon B. -Glutamyl transpeptidase in transplantable, chemically induced rat hepatomas and "spontaneous" mouse hepatomas. J Natl Cancer Inst. 1972 May;48(5):1393–1401. [PubMed] [Google Scholar]
  25. Gallo R. C., Meyskens F. L., Jr Advances in the viral etiology of leukemia and lymphoma. Semin Hematol. 1978 Oct;15(4):379–398. [PubMed] [Google Scholar]
  26. Geil R. G., Lamar J. K. FDA studies of estrogen, progestogens, and estrogen/progestogen combinations in the dog and monkey. J Toxicol Environ Health. 1977 Sep;3(1-2):179–193. doi: 10.1080/15287397709529557. [DOI] [PubMed] [Google Scholar]
  27. Gordon D. E., Olson C. Meningiomas and fibroblastic neoplasia in calves induced with the bovine papilloma virus. Cancer Res. 1968 Dec;28(12):2423–2431. [PubMed] [Google Scholar]
  28. Gosselin S., Capen C. C., Martin S. L. Lymphocytic thyroiditis in the dog. Am J Pathol. 1978 Jan;90(1):285–288. [PMC free article] [PubMed] [Google Scholar]
  29. HJERPE C. A., THEILEN G. H. MALIGNANT MELANOMAS IN PORCINE LITTERMATES. J Am Vet Med Assoc. 1964 May 15;144:1129–1131. [PubMed] [Google Scholar]
  30. Hardy W. D., Jr, Old L. J., Hess P. W., Essex M., Cotter S. Horizontal transmission of feline leukaemia virus. Nature. 1973 Aug 3;244(5414):266–269. doi: 10.1038/244266a0. [DOI] [PubMed] [Google Scholar]
  31. Hargis A. M., Thomassen R. W., Phemister R. D. Chronic dermatosis and cutaneous squamous cell carcinoma in the beagle dog. Vet Pathol. 1977 May;14(3):218–228. doi: 10.1177/030098587701400304. [DOI] [PubMed] [Google Scholar]
  32. Hayes H. M., Jr Canine bladder cancer: epidemiologic features. Am J Epidemiol. 1976 Dec;104(6):673–677. doi: 10.1093/oxfordjournals.aje.a112346. [DOI] [PubMed] [Google Scholar]
  33. Hayes H. M., Jr, Fraumeni J. F., Jr Canine thyroid neoplasms: epidemiologic features. J Natl Cancer Inst. 1975 Oct;55(4):931–934. doi: 10.1093/jnci/55.4.931. [DOI] [PubMed] [Google Scholar]
  34. Hayes H. M., Jr, Fraumeni J. F., Jr Epidemiological features of canine renal neoplasms. Cancer Res. 1977 Aug;37(8 Pt 1):2553–2556. [PubMed] [Google Scholar]
  35. Hayes H. M., Jr, Pendergrass T. W. Canine testicular tumors: epidemiologic features of 410 dogs. Int J Cancer. 1976 Oct 15;18(4):482–487. doi: 10.1002/ijc.2910180413. [DOI] [PubMed] [Google Scholar]
  36. Hayes H. M., Jr, Young J. L., Jr Epidemiologic features of canine ovarian neoplasms. Gynecol Oncol. 1978 Aug;6(4):348–353. doi: 10.1016/0090-8258(78)90041-0. [DOI] [PubMed] [Google Scholar]
  37. Hayes H. M., Priester W. A., Jr, Pendergrass T. W. Occurrence of nervous-tissue tumors in cattle, horses, cats and dogs. Int J Cancer. 1975 Jan 15;15(1):39–47. doi: 10.1002/ijc.2910150106. [DOI] [PubMed] [Google Scholar]
  38. Hernandez F. J., Fernandez B. B., Chertack M., Gage P. A. Feline mammary carcinoma and progestogens. Feline Pract. 1975 Sep-Oct;5(5):45–48. [PubMed] [Google Scholar]
  39. Huseby R. A. Utility and failure of models in oncology. Fed Proc. 1969 Jan-Feb;28(1):211–215. [PubMed] [Google Scholar]
  40. JARRETT W. F., MARTIN W. B., CRIGHTON G. W., DALTON R. G., STEWART M. F. TRANSMISSION EXPERIMENTS WITH LEUKEMIA (LYMPHOSARCOMA). Nature. 1964 May 9;202:566–567. doi: 10.1038/202566a0. [DOI] [PubMed] [Google Scholar]
  41. Jarrett W. F., McNeil P. E., Grimshaw W. T., Selman I. E., McIntyre W. I. High incidence area of cattle cancer with a possible interaction between an environmental carcinogen and a papilloma virus. Nature. 1978 Jul 20;274(5668):215–217. doi: 10.1038/274215a0. [DOI] [PubMed] [Google Scholar]
  42. Kurihara M., Shirakabe H., Murakami T., Yasui A., Izumi T. A new method for producing adenocarcinomas in the stomach of dogs with N-ethyl-N'-nitro-N-nitrosoguanidine. Gan. 1974 Apr;65(2):163–177. [PubMed] [Google Scholar]
  43. Ladds P. W., Entwistle K. W. Observations on squamous cell carcinomas of sheep in Queensland, Australia. Br J Cancer. 1977 Jan;35(1):110–114. doi: 10.1038/bjc.1977.10. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Leav I., Schiller A. L., Rijnberk A., Legg M. A., der Kinderen P. J. Adenomas and carcinomas of the canine and feline thyroid. Am J Pathol. 1976 Apr;83(1):61–122. [PMC free article] [PubMed] [Google Scholar]
  45. Lerner A. B., Cage G. W. Melanomas in horses. Yale J Biol Med. 1973 Dec;46(5):646–649. [PMC free article] [PubMed] [Google Scholar]
  46. Lingeman C. H., Garner F. M., Taylor D. O. Spontaneous gastric adenocarcinomas of dogs: a review. J Natl Cancer Inst. 1971 Jul;47(1):137–153. [PubMed] [Google Scholar]
  47. Lu S. T., Michaelson S. M., Quinlan W. J. Sequential pathophysiologic effects of ionizing radiation on the beagle thyroid gland. J Natl Cancer Inst. 1973 Aug;51(2):419–441. [PubMed] [Google Scholar]
  48. Madewell B. R., Priester W. A., Gillette E. L., Snyder S. P. Neoplasms of the nasal passages and paranasal sinuses in domesticated animals as reported by 13 veterinary colleges. Am J Vet Res. 1976 Jul;37(7):851–856. [PubMed] [Google Scholar]
  49. Manning P. J., Millikan L. E., Cox V. S., Carey K. D., Hook R. R., Jr Congenital cutaneous and visceral melanomas of Sinclair miniature swine: three case reports. J Natl Cancer Inst. 1974 May;52(5):1559–1566. doi: 10.1093/jnci/52.5.1559. [DOI] [PubMed] [Google Scholar]
  50. Marhold J., Matrka M., Hub M., Ruffer F. The possible complicity of diphenyline in the origine of tumours in the manufacture of benzidine. Neoplasma. 1968;15(1):3–10. [PubMed] [Google Scholar]
  51. McTaggart H. S., Head K. W., Laing A. H. Evidence for a genetic factor in the transmission of spontaneous lymphosarcoma (leukaemia) of young pigs. Nature. 1971 Aug 20;232(5312):557–558. doi: 10.1038/232557a0. [DOI] [PubMed] [Google Scholar]
  52. Migaki G., Nelson L. W., Todd G. C. Prevalence of embryonal nephroma in slaughtered swine. J Am Vet Med Assoc. 1971 Aug 15;159(4):441–442. [PubMed] [Google Scholar]
  53. Millikan L. E., Hook R. R., Manning P. J. Immunobiology of melanoma. Gross and ultrastructural studies in a new melanoma model: the Sinclair swine. Yale J Biol Med. 1973 Dec;46(5):631–645. [PMC free article] [PubMed] [Google Scholar]
  54. Misdorp W., Weijer K. Animal model of human disease: breast cancer. Am J Pathol. 1980 Feb;98(2):573–576. [PMC free article] [PubMed] [Google Scholar]
  55. NELSON A. A., WOODARD G. Tumors of the urinary bladder, gall bladder, and liver in dogs fed o-aminoazotoluene or p-dimethylaminoazobenzene. J Natl Cancer Inst. 1953 Jun;13(6):1497–1509. [PubMed] [Google Scholar]
  56. Nelson L. W., Carlton W. W., Weikel J. H., Jr Canine mammary neoplasms and progestogens. JAMA. 1972 Mar 20;219(12):1601–1606. [PubMed] [Google Scholar]
  57. Newberne P. M., Butler W. H. Acute and chronic effects of aflatoxin on the liver of domestic and laboratory animals: a review. Cancer Res. 1969 Jan;29(1):236–250. [PubMed] [Google Scholar]
  58. Njoku C. O., Shannon D., Chineme C. N., Bida S. A. Ovine nasal adenopapilloma: incidence and clinicopathologic studies. Am J Vet Res. 1978 Nov;39(11):1850–1852. [PubMed] [Google Scholar]
  59. OLSON C., PAMUKCU A. M., BROBST D. F., KOWALCZYK T., SATTER E. J., PRICE J. M. A urinary bladder tumor induced by a bovine cutaneous papilloma agent. Cancer Res. 1959 Aug;19:779–782. [PubMed] [Google Scholar]
  60. Olson C., Gordon D. E., Robl M. G., Lee K. P. Oncogenicity of bovine papilloma virus. Arch Environ Health. 1969 Dec;19(6):827–837. doi: 10.1080/00039896.1969.10666938. [DOI] [PubMed] [Google Scholar]
  61. Owen L. N., Briggs M. H. Contraceptive steroid toxicology in the Beagle dog and its relevance to human carcinogenicity. Curr Med Res Opin. 1976;4(5):309–329. doi: 10.1185/03007997609109324. [DOI] [PubMed] [Google Scholar]
  62. Paladugu R. R., Shors E. C., Cohen A. H., Matsumura K., Benfield J. R. Induction of lung cancers in preselected, localized sites in the dog. J Natl Cancer Inst. 1980 Nov;65(5):921–927. [PubMed] [Google Scholar]
  63. Park J. F., Bair W. J., Busch R. H. Progress in beagle dog studies with transuranium elements at Battelle-Northwest. Health Phys. 1972 Jun;22(6):803–810. doi: 10.1097/00004032-197206000-00041. [DOI] [PubMed] [Google Scholar]
  64. Patnaik A. K., Liu S. K., Hurvitz A. I., McClelland A. J. Canine chemodectoma (extra-adrenal paragangliomas)--a comparative study. J Small Anim Pract. 1975 Dec;16(12):785–801. doi: 10.1111/j.1748-5827.1975.tb05813.x. [DOI] [PubMed] [Google Scholar]
  65. Pendergrass T. W., Hayes H. M., Jr Cryptorchism and related defects in dogs: epidemiologic comparisons with man. Teratology. 1975 Aug;12(1):51–55. doi: 10.1002/tera.1420120107. [DOI] [PubMed] [Google Scholar]
  66. Peters J. A. Canine mastocytoma: excess risk as related to ancestry. J Natl Cancer Inst. 1969 Mar;42(3):435–443. [PubMed] [Google Scholar]
  67. Ponomarkov V., Mackey L. J. Tumours of the liver and biliary system. Bull World Health Organ. 1976;53(2-3):187–194. [PMC free article] [PubMed] [Google Scholar]
  68. Pospischil A., Haenichen T., Schaeffler H. Histological and electron microscopic studies of endemic ethmoidal carcinomas in cattle. Vet Pathol. 1979 Mar;16(2):180–190. doi: 10.1177/030098587901600203. [DOI] [PubMed] [Google Scholar]
  69. Price J. M., Pamukcu A. M. The induction of neoplasms of the urinary bladder of the cow and the small intestine of the rat by feeding bracken fern (Pteris aquilina). Cancer Res. 1968 Nov;28(11):2247–2251. [PubMed] [Google Scholar]
  70. Priester W. A. Canine lymphoma: relative risk in the boxer breed. J Natl Cancer Inst. 1967 Nov;39(5):833–845. [PubMed] [Google Scholar]
  71. Priester W. A. Data from eleven United States and Canadian colleges of veterinary medicine on pancreatic carcinoma in domestic animals. Cancer Res. 1974 Jun;34(6):1372–1375. [PubMed] [Google Scholar]
  72. Priester W. A. Occurrence of mammary neoplasms in bitches in relation to breed, age, tumour type, and geographical region from which reported. J Small Anim Pract. 1979 Jan;20(1):1–11. doi: 10.1111/j.1748-5827.1979.tb07014.x. [DOI] [PubMed] [Google Scholar]
  73. Priester W. A. Pancreatic islet cell tumors in domestic animals. Data from 11 colleges of veterinary medicine in the United States and Canada. J Natl Cancer Inst. 1974 Jul;53(1):227–229. doi: 10.1093/jnci/53.1.227. [DOI] [PubMed] [Google Scholar]
  74. Pritchard D. J., Finkel M. P., Reilly C. A., Jr The etiology of osteosarcoma. A review of current considerations. Clin Orthop Relat Res. 1975 Sep;(111):14–22. doi: 10.1097/00003086-197509000-00003. [DOI] [PubMed] [Google Scholar]
  75. Prout G. R., Jr Bladder carcinoma. N Engl J Med. 1972 Jul 13;287(2):86–90. doi: 10.1056/NEJM197207132870207. [DOI] [PubMed] [Google Scholar]
  76. ROONEY J. R. Liver carcinoma in the dog. Acta Pathol Microbiol Scand. 1959;45(4):321–330. doi: 10.1111/j.1699-0463.1959.tb04717.x. [DOI] [PubMed] [Google Scholar]
  77. Radomski J. L. The primary aromatic amines: their biological properties and structure-activity relationships. Annu Rev Pharmacol Toxicol. 1979;19:129–157. doi: 10.1146/annurev.pa.19.040179.001021. [DOI] [PubMed] [Google Scholar]
  78. Ramadan R. O. Squamous cell carcinoma of the perineum of the goat. Br Vet J. 1975 May-Jun;131(3):347–350. doi: 10.1016/s0007-1935(17)35292-2. [DOI] [PubMed] [Google Scholar]
  79. Reif J. S., Brodey R. S. The relationship between cryptorchidism and canine testicular neoplasia. J Am Vet Med Assoc. 1969 Dec 15;155(12):2005–2010. [PubMed] [Google Scholar]
  80. Reif J. S., Cohen D. The environmental distribution of canine respiratory tract neoplasms. Arch Environ Health. 1971 Jan;22(1):136–140. doi: 10.1080/00039896.1971.10665823. [DOI] [PubMed] [Google Scholar]
  81. Riser W. H., Brodey R. S., Biery D. N. Bone infarctions associated with malignant bone tumors in dogs. J Am Vet Med Assoc. 1972 Feb 15;160(4):414–421. [PubMed] [Google Scholar]
  82. Rockey E. E., Speer F. D. The ill effects of cigarette smoking in dogs. Int Surg. 1966 Dec;46(6):520–530. [PubMed] [Google Scholar]
  83. Ross A. D. Small intestinal carcinoma in sheep. Aust Vet J. 1980 Jan;56(1):25–33. doi: 10.1111/j.1751-0813.1980.tb02536.x. [DOI] [PubMed] [Google Scholar]
  84. STAUB E. W., EISENSTEIN R., HASS G., BEATTIE E. J., Jr BRONCHOGENIC CARCINOMA PRODUCED EXPERIMENTALLY IN THE NORMAL DOG. J Thorac Cardiovasc Surg. 1965 Mar;49:364–372. [PubMed] [Google Scholar]
  85. STERNBERG S. S., POPPER H., OSER B. L., OSER M. Gallbladder and bile duct adenocarcinomas in dogs after long term feeding of aramite. Cancer. 1960 Jul-Aug;13:780–789. doi: 10.1002/1097-0142(196007/08)13:4<780::aid-cncr2820130421>3.0.co;2-7. [DOI] [PubMed] [Google Scholar]
  86. Schaller R. T., Jr, Stevenson J. K. Development of carcinoma of the thyroid in iodine-deficient mice. Cancer. 1966 Aug;19(8):1063–1080. doi: 10.1002/1097-0142(196608)19:8<1063::aid-cncr2820190804>3.0.co;2-a. [DOI] [PubMed] [Google Scholar]
  87. Schmähl D., Habs M., Ivankovic S. Carcinogenesis of N-nitrosodiethylamine (DENA) in chickens and domestic cats. Int J Cancer. 1978 Nov 15;22(5):552–557. doi: 10.1002/ijc.2910220508. [DOI] [PubMed] [Google Scholar]
  88. Schneider R., Dorn C. R., Taylor D. O. Factors influencing canine mammary cancer development and postsurgical survival. J Natl Cancer Inst. 1969 Dec;43(6):1249–1261. [PubMed] [Google Scholar]
  89. Shope R. E., Hurst E. W. INFECTIOUS PAPILLOMATOSIS OF RABBITS : WITH A NOTE ON THE HISTOPATHOLOGY. J Exp Med. 1933 Oct 31;58(5):607–624. doi: 10.1084/jem.58.5.607. [DOI] [PMC free article] [PubMed] [Google Scholar]
  90. Silverberg S. G. Carcinoma arising in adenomatous polyps of the rectum in a dog. Dis Colon Rectum. 1971 May-Jun;14(3):191–194. doi: 10.1007/BF02553183. [DOI] [PubMed] [Google Scholar]
  91. Simpson B. H. An epidemiological study of carcinoma of the small intestine in New Zealand sheep. N Z Vet J. 1972 Jun;20(6):91–97. doi: 10.1080/00480169.1972.34022. [DOI] [PubMed] [Google Scholar]
  92. Sinibaldi K., Rosen H., Liu S. K., DeAngelis M. Tumors associated with metallic implants in animals. Clin Orthop Relat Res. 1976 Jul-Aug;(118):257–266. [PubMed] [Google Scholar]
  93. Stabenfeldt G. H., Hughes J. P., Kennedy P. C., Meagher D. M., Neely D. P. Clinical findings, pathological changes and endocrinological secretory patterns in mares with ovarian tumours. J Reprod Fertil Suppl. 1979;(27):277–285. [PubMed] [Google Scholar]
  94. Sugimura T., Tanaka N., Kawachi T., Kogure K., Fujimura S. Production of stomach cancer in dogs by N-methyl-N'-nitro-N-nitrosoguanidine. Gan. 1971 Feb;62(1):67–67. [PubMed] [Google Scholar]
  95. Thurman G. B., Mays C. W., Taylor G. N., Keane A. T., Sissons H. A. Skeletal location of radiation-induced and naturally occurring osteosarcomas in man and dog. Cancer Res. 1973 Jul;33(7):1604–1607. [PubMed] [Google Scholar]
  96. Tjalma R. A. Canine bone sarcoma: estimation of relative risk as a function of body size. J Natl Cancer Inst. 1966 Jun;36(6):1137–1150. [PubMed] [Google Scholar]
  97. Vítovec J. Hepatozelluläre Karzinome beim Rind und ihre Beziehung zur biliären Zirrhose fasziolären Ursprungs. Vet Pathol. 1974;11(6):548–557. doi: 10.1177/030098587401100609. [DOI] [PubMed] [Google Scholar]
  98. Warner M. R. Age incidence and site distribution of mammary dysplasias in young beagle bitches. J Natl Cancer Inst. 1976 Jul;57(1):57–61. doi: 10.1093/jnci/57.1.57. [DOI] [PubMed] [Google Scholar]
  99. Watrach A. M., Small E., Case M. T. Canine papilloma: progression of oral papilloma to carcinoma. J Natl Cancer Inst. 1970 Nov;45(5):915–920. [PubMed] [Google Scholar]
  100. Wilkie B. N., Krook L. Ultimobranchial tumor of the thyroid and pheochromocytoma in the bull. Pathol Vet. 1970;7(2):126–134. doi: 10.1177/030098587000700204. [DOI] [PubMed] [Google Scholar]
  101. Wold W. S., Green M. Historic milestones in cancer virology. Semin Oncol. 1979 Dec;6(4):461–478. [PubMed] [Google Scholar]
  102. Wright B. J., Conner G. H. Adrenal neoplasms in slaughtered cattle. Cancer Res. 1968 Feb;28(2):251–263. [PubMed] [Google Scholar]
  103. Wronski T. J., Smith J. M., Jee W. S. The microdistribution and retention of injected 239Pu on trabecular bone surfaces of the beagle: implications for the induction of osteosarcoma. Radiat Res. 1980 Jul;83(1):74–89. [PubMed] [Google Scholar]
  104. Yang C. S. Research on esophageal cancer in China: a review. Cancer Res. 1980 Aug;40(8 Pt 1):2633–2644. [PubMed] [Google Scholar]
  105. Yang T. J., Jones J. B. Canine transmissible venereal sarcoma: transplantation studies in neonatal and adult dogs. J Natl Cancer Inst. 1973 Dec;51(6):1915–1918. doi: 10.1093/jnci/51.6.1915. [DOI] [PubMed] [Google Scholar]
  106. Yonemichi H., Ohgi T., Fujimoto Y., Okada K., Onuma M., Mikami T. Intranasal tumor of the ethmoid olfactory mucosa in sheep. Am J Vet Res. 1978 Oct;39(10):1599–1606. [PubMed] [Google Scholar]
  107. Young D. M., Capen C. C., Black H. E. Calcitonin activity in ultimobranchial neoplasms from bulls. Vet Pathol. 1971;8(1):19–27. doi: 10.1177/030098587100800104. [DOI] [PubMed] [Google Scholar]
  108. Zarrin K., Hänichen T. Comparative histopathological study of the canine thyroid gland in London and Munich. J Small Anim Pract. 1974 May;15(5):329–342. doi: 10.1111/j.1748-5827.1974.tb05700.x. [DOI] [PubMed] [Google Scholar]
  109. Zwicker G. M., Filipy R. E., Park J. F., Loscutoff S. M., Ragan H. A., Stevens D. L. Clinical and pathological effects of cigarette smoke exposure in beagle dogs. Arch Pathol Lab Med. 1978 Dec;102(12):623–628. [PubMed] [Google Scholar]
  110. von Sandersleben J., Hänichen T. Tumours of the thyroid gland. Bull World Health Organ. 1974;50(1-2):35–42. [PMC free article] [PubMed] [Google Scholar]

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