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. 1988 Sep;56(9):2507–2511. doi: 10.1128/iai.56.9.2507-2511.1988

Effect of intravenous silica on the course of Nocardia asteroides pneumonia.

C Pomeroy 1, G A Filice 1
PMCID: PMC259597  PMID: 3045004

Abstract

Silica, a known toxin of mononuclear phagocytes, was administered intravenously to mice during Nocardia asteroides pneumonia. Mice that received silica had a sevenfold decrease in the number of peripheral blood monocytes and developed more severe N. asteroides pneumonia than control mice. Lung histology in mice that received silica resembled that of mice with impaired cell-mediated immunity. These results are most consistent with the explanation that silica injures blood monocytes and impairs their contributions to pulmonary host defense.

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Selected References

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