Abstract
Although acute renal failure, caused either by renal ischemia or nephrotoxic agents, is usually characterized by oliguria, a severe fall in glomerular filtration rate, and a fall in renal blood flow, some patients and experimental models display a non-oliguric pattern of renal injury. The present study was designed to evaluate the mechanism of preservation of high urinary flow rate under this condition. Following the administration of the aminoglycoside gentamicin to rats for five days, a decrease in concentrating ability was demonstrated, caused by impaired vasopressin-mediated water transport. Further treatment resulted in a fall in Cin to 15 percent of control, although RBF was reduced to only 67 percent of control, and urine flow rate rose above control levels. Induction of acute and renal failure with dichromate was associated with variable high or low urinary flow rates according to pre-injury intake of sodium. Urine volume correlated directly with cortical blood flow. These data suggest that the non-oliguric pattern of acute renal injury is caused by preservation of cortical perfusion in the setting of severe tubular injury.
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Selected References
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- Anderson R. J., Linas S. L., Berns A. S., Henrich W. L., Miller T. R., Gabow P. A., Schrier R. W. Nonoliguric acute renal failure. N Engl J Med. 1977 May 19;296(20):1134–1138. doi: 10.1056/NEJM197705192962002. [DOI] [PubMed] [Google Scholar]
- Appel G. B., Neu H. C. Gentamicin in 1978. Ann Intern Med. 1978 Oct;89(4):528–538. doi: 10.7326/0003-4819-89-4-528. [DOI] [PubMed] [Google Scholar]
- Appel G. B., Neu H. C. The nephrotoxicity of antimicrobial agents (third of three parts). N Engl J Med. 1977 Apr 7;296(14):784–787. doi: 10.1056/NEJM197704072961404. [DOI] [PubMed] [Google Scholar]
- Bankir L., Tan M. M., Grünfeld J. P. Measurement of glomerular blood flow in rabbits and rats: erroneous findings with 15-micron microspheres. Kidney Int. 1979 Feb;15(2):126–133. doi: 10.1038/ki.1979.18. [DOI] [PubMed] [Google Scholar]
- Kashgarian M., Siegel N. J., Ries A. L., DiMeola H. J., Hayslett J. P. Hemodynamic aspects in development and recovery phases of experimental postischemic acute renal failure. Kidney Int Suppl. 1976 Oct;6:S160–S168. [PubMed] [Google Scholar]
- Kosek J. C., Mazze R. I., Cousins M. J. Nephrotoxicity of gentamicin. Lab Invest. 1974 Jan;30(1):48–57. [PubMed] [Google Scholar]
- Minuth A. N., Terrell J. B., Jr, Suki W. N. Acute renal failure: a study of the course and prognosis of 104 patients and of the role of furosemide. Am J Med Sci. 1976 May-Jun;271(3):317–324. doi: 10.1097/00000441-197605000-00007. [DOI] [PubMed] [Google Scholar]
- Siegel N. J., Feldman R. A., Lytton B., Hayslett J. P., Kashgarian M. Renal cortical blood flow distribution in obstructive nephropathy in rats. Circ Res. 1977 Apr;40(4):379–384. doi: 10.1161/01.res.40.4.379. [DOI] [PubMed] [Google Scholar]
- Siegel N. J., Gunstream S. K., Handler R. I., Kashgarian M. Renal function and cortical blood flow during the recovery phase of acute renal failure. Kidney Int. 1977 Sep;12(3):199–204. doi: 10.1038/ki.1977.101. [DOI] [PubMed] [Google Scholar]
- Stein J. H., Lifschitz M. D., Barnes L. D. Current concepts on the pathophysiology of acute renal failure. Am J Physiol. 1978 Mar;234(3):F171–F181. doi: 10.1152/ajprenal.1978.234.3.F171. [DOI] [PubMed] [Google Scholar]
- Stein J. H., Lifschitz M. D., Barnes L. D. Current concepts on the pathophysiology of acute renal failure. Am J Physiol. 1978 Mar;234(3):F171–F181. doi: 10.1152/ajprenal.1978.234.3.F171. [DOI] [PubMed] [Google Scholar]