Abstract
The mechanism of fever in patients with Hodgkin's disease was investigated by examining endogenous pyrogen production by blood, spleen, and lymph node cells incubated in vitro. Blood leucocytes from febrile or afebrile patients with Hodgkin's disease did not produce pyrogen spontaneously. Spleen cells, however, frequently released pyrogen during initial incubations, unlike spleen cells from patients with non-malignant diseases. Pyrogen production occurred from spleens without observed pathologic infiltrates of Hodgkin's disease. Lymph nodes involved with Hodgkin's disease produced pyrogen more frequently than did nodes involved with other diseases. Pyrogen production by tissue cells was prolonged, required protein synthesis, and in some cases was due to mononuclear cells; it did not correlate with fever in the patient. These studies demonstrate spontaneous production of endogenous pyrogen in vitro by lymphoid tissue cells from patients with Hodgkin's disease.
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- ATKINS E., HEIJN C., Jr STUDIES ON TUBERCULIN FEVER. 3. MECHANISMS INVOLVED IN THE RELEASE OF ENDOGENOUS PYROGEN IN VITRO. J Exp Med. 1965 Aug 1;122:207–235. doi: 10.1084/jem.122.2.207. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Atkins E., Feldman J. D., Francis L., Hursh E. Studies on the mechanism of fever accompanying delayed hypersensitivity. The role of the sensitized lymphocyte. J Exp Med. 1972 May 1;135(5):1113–1132. doi: 10.1084/jem.135.5.1113. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bodel P., Dillard M. Studies on steroid fever: I. Production of leukocyte pyrogen in vitro by etiocholanolone. J Clin Invest. 1968 Jan;47(1):107–117. doi: 10.1172/JCI105701. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bodel P. Studies on the mechanism of endogenous pyrogen production. I. Investigation of new protein synthesis in stimulated human blood leucocytes. Yale J Biol Med. 1970 Dec;43(3):145–163. [PMC free article] [PubMed] [Google Scholar]
- Dillard G. M., Bodel P. Studies on steroid fever. II. Pyrogenic and anti-pyrogenic activity in vitro of some endogenous steroids of man. J Clin Invest. 1970 Dec;49(12):2418–2426. doi: 10.1172/JCI106461. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KOEHLER P. R., WOHL G. T., SCHAFFER B. LYMPHANGIOGRAPHY--A SURVEY OF ITS CURRENT STATUS. Am J Roentgenol Radium Ther Nucl Med. 1964 Jun;91:1216–1221. [PubMed] [Google Scholar]
- Moore D. M., Cheuk S. F., Morton J. D., Berlin R. D., Wood W. B., Jr Studies on the pathogenesis of fever. 18. Activation of leukocytes for pyrogen production. J Exp Med. 1970 Jan 1;131(1):179–188. doi: 10.1084/jem.131.1.179. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nordlund J. J., Root R. K., Wolff S. M. Studies on the origin of human leukocytic pyrogen. J Exp Med. 1970 Apr 1;131(4):727–743. doi: 10.1084/jem.131.4.727. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Order S. E., Hellman S. Pathogenesis of Hodgkin's disease. Lancet. 1972 Mar 11;1(7750):571–573. doi: 10.1016/s0140-6736(72)90360-1. [DOI] [PubMed] [Google Scholar]
- Order S. E., Porter M., Hellman S. Hodgkin's disease: evidence for a tumor-associated antigen. N Engl J Med. 1971 Aug 26;285(9):471–474. doi: 10.1056/NEJM197108262850901. [DOI] [PubMed] [Google Scholar]
- Rawlins M. D., Luff R. H., Cranston W. I. Pyrexia in renal carcinoma. Lancet. 1970 Jun 27;1(7661):1371–1373. doi: 10.1016/s0140-6736(70)91274-2. [DOI] [PubMed] [Google Scholar]
- Root R. K., Nordlund J. J., Wolff S. M. Factors affecting the quantitative production and assay of human leukocytic pyrogen. J Lab Clin Med. 1970 Apr;75(4):679–693. [PubMed] [Google Scholar]
- SNELL E. S. Pyrogenic properties of human pathological fluids. Clin Sci. 1962 Aug;23:141–150. [PubMed] [Google Scholar]
- Sokal J. E., Shimaoka K. Pyrogen in the urine of febrile patients with Hodgkin's disease. Nature. 1967 Sep 9;215(5106):1183–1185. doi: 10.1038/2151183b0. [DOI] [PubMed] [Google Scholar]