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. 1982 May-Aug;55(3-4):219–223.

Respiratory syncytial virus: its transmission in the hospital environment.

C B Hall
PMCID: PMC2596445  PMID: 6758370

Abstract

Respiratory syncytial virus (RSV) over the past two decades has been recognized as the most important cause of lower respiratory tract disease in infants and young children. Recently, it has also been identified as a major nosocomial hazard on pediatric wards. The potential for RSV to spread on such wards is underlined by several singular characteristics of RSV. It arrives in yearly epidemics and is highly contagious in all age groups. Immunity is of short duration, allowing repeated infections to occur. Thus, during an epidemic 20--40 percent of infants admitted for other conditions may acquire nosocomial RSV infection, as well as 50 percent of the ward personnel. The usual infection control procedures for respiratory illnesses have had limited success in controlling the spread of RSV. This may be due in part to the modes of transmission of RSV. Inoculation occurs mainly through the eye and nose, rather than the mouth. This may be via large-particle aerosols or droplets, requiring close contact. The virus, however, does not seem capable of traversing distances by small-particle aerosols. Nevertheless, it is able to remain infectious on various environmental surfaces, suggesting fomites as a source of spread. Indeed, inoculation after touching such contaminated surfaces can occur, and may be a major second means of spread, in hospitals as well as in families.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BEEM M., EGERER R., ANDERSON J. RESPIRATORY SYNCYTIAL VIRUS NEUTRALIZING ANTIBODIES IN PERSONS RESIDING IN CHICAGO, ILLINOIS. Pediatrics. 1964 Dec;34:761–770. [PubMed] [Google Scholar]
  2. BLOUNT R. E., Jr, MORRIS J. A., SAVAGE R. E. Recovery of cytopathogenic agent from chimpanzees with coryza. Proc Soc Exp Biol Med. 1956 Jul;92(3):544–549. doi: 10.3181/00379727-92-22538. [DOI] [PubMed] [Google Scholar]
  3. Brandt C. D., Kim H. W., Arrobio J. O., Jeffries B. C., Wood S. C., Chanock R. M., Parrott R. H. Epidemiology of respiratory syncytial virus infection in Washington, D.C. 3. Composite analysis of eleven consecutive yearly epidemics. Am J Epidemiol. 1973 Nov;98(5):355–364. doi: 10.1093/oxfordjournals.aje.a121565. [DOI] [PubMed] [Google Scholar]
  4. CHANOCK R. M., PARROTT R. H. ACUTE RESPIRATORY DISEASE IN INFANCY AND CHILDHOOD: PRESENT UNDERSTANDING AND PROSPECTS FOR PREVENTION. Pediatrics. 1965 Jul;36:21–39. [PubMed] [Google Scholar]
  5. Denny F. W., Collier A. M., Henderson F. W., Clyde W. A., Jr The epidemiology of bronchiolitis. Pediatr Res. 1977 Mar;11(3 Pt 2):234–236. [PubMed] [Google Scholar]
  6. Gardner P. S., Court S. D., Brocklebank J. T., Downham M. A., Weightman D. Virus cross-infection in paediatric wards. Br Med J. 1973 Jun 9;2(5866):571–575. doi: 10.1136/bmj.2.5866.571. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Gardner P. S. How etiologic, pathologic, and clinical diagnoses can be made in a correlated fashion. Pediatr Res. 1977 Mar;11(3 Pt 2):254–261. [PubMed] [Google Scholar]
  8. Glezen P., Denny F. W. Epidemiology of acute lower respiratory disease in children. N Engl J Med. 1973 Mar 8;288(10):498–505. doi: 10.1056/NEJM197303082881005. [DOI] [PubMed] [Google Scholar]
  9. Hall C. B., Douglas R. G., Jr, Geiman J. M., Messner M. K. Nosocomial respiratory syncytial virus infections. N Engl J Med. 1975 Dec 25;293(26):1343–1346. doi: 10.1056/NEJM197512252932604. [DOI] [PubMed] [Google Scholar]
  10. Hall C. B., Douglas R. G., Jr, Geiman J. M. Possible transmission by fomites of respiratory syncytial virus. J Infect Dis. 1980 Jan;141(1):98–102. doi: 10.1093/infdis/141.1.98. [DOI] [PubMed] [Google Scholar]
  11. Hall C. B., Douglas R. G., Jr, Geiman J. M. Respiratory syncytial virus infections in infants: quantitation and duration of shedding. J Pediatr. 1976 Jul;89(1):11–15. doi: 10.1016/s0022-3476(76)80918-3. [DOI] [PubMed] [Google Scholar]
  12. Hall C. B., Douglas R. G., Jr Modes of transmission of respiratory syncytial virus. J Pediatr. 1981 Jul;99(1):100–103. doi: 10.1016/s0022-3476(81)80969-9. [DOI] [PubMed] [Google Scholar]
  13. Hall C. B., Douglas R. G., Jr Nosocomial respiratory syncytial viral infections. Should gowns and masks be used? Am J Dis Child. 1981 Jun;135(6):512–515. doi: 10.1001/archpedi.1981.02130300012006. [DOI] [PubMed] [Google Scholar]
  14. Hall C. B., Douglas R. G., Jr, Schnabel K. C., Geiman J. M. Infectivity of respiratory syncytial virus by various routes of inoculation. Infect Immun. 1981 Sep;33(3):779–783. doi: 10.1128/iai.33.3.779-783.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Hall C. B., Geiman J. M., Biggar R., Kotok D. I., Hogan P. M., Douglas G. R., Jr Respiratory syncytial virus infections within families. N Engl J Med. 1976 Feb 19;294(8):414–419. doi: 10.1056/NEJM197602192940803. [DOI] [PubMed] [Google Scholar]
  16. Hall C. B., Geiman J. M., Douglas R. G., Jr, Meagher M. P. Control of nosocomial respiratory syncytial viral infections. Pediatrics. 1978 Nov;62(5):728–732. [PubMed] [Google Scholar]
  17. Hall C. B., Kopelman A. E., Douglas R. G., Jr, Geiman J. M., Meagher M. P. Neonatal respiratory syncytial virus infection. N Engl J Med. 1979 Feb 22;300(8):393–396. doi: 10.1056/NEJM197902223000803. [DOI] [PubMed] [Google Scholar]
  18. Hall W. J., Hall C. B., Speers D. M. Respiratory syncytial virus infection in adults: clinical, virologic, and serial pulmonary function studies. Ann Intern Med. 1978 Feb;88(2):203–205. doi: 10.7326/0003-4819-88-2-203. [DOI] [PubMed] [Google Scholar]
  19. Henderson F. W., Collier A. M., Clyde W. A., Jr, Denny F. W. Respiratory-syncytial-virus infections, reinfections and immunity. A prospective, longitudinal study in young children. N Engl J Med. 1979 Mar 8;300(10):530–534. doi: 10.1056/NEJM197903083001004. [DOI] [PubMed] [Google Scholar]
  20. Hendley J. O., Wenzel R. P., Gwaltney J. M., Jr Transmission of rhinovirus colds by self-inoculation. N Engl J Med. 1973 Jun 28;288(26):1361–1364. doi: 10.1056/NEJM197306282882601. [DOI] [PubMed] [Google Scholar]
  21. Kim H. W., Arrobio J. O., Brandt C. D., Jeffries B. C., Pyles G., Reid J. L., Chanock R. M., Parrott R. H. Epidemiology of respiratory syncytial virus infection in Washington, D.C. I. Importance of the virus in different respiratory tract disease syndromes and temporal distribution of infection. Am J Epidemiol. 1973 Sep;98(3):216–225. doi: 10.1093/oxfordjournals.aje.a121550. [DOI] [PubMed] [Google Scholar]
  22. MacDonald N. E., Hall C. B., Suffin S. C., Alexson C., Harris P. J., Manning J. A. Respiratory syncytial viral infection in infants with congenital heart disease. N Engl J Med. 1982 Aug 12;307(7):397–400. doi: 10.1056/NEJM198208123070702. [DOI] [PubMed] [Google Scholar]
  23. Monto A. S., Lim S. K. The Tecumseh study of respiratory illness. 3. Incidence and periodicity of respiratory syncytial virus and Mycoplasma pneumoniae infections. Am J Epidemiol. 1971 Sep;94(3):290–301. doi: 10.1093/oxfordjournals.aje.a121322. [DOI] [PubMed] [Google Scholar]
  24. Parrott R. H., Kim H. W., Arrobio J. O., Hodes D. S., Murphy B. R., Brandt C. D., Camargo E., Chanock R. M. Epidemiology of respiratory syncytial virus infection in Washington, D.C. II. Infection and disease with respect to age, immunologic status, race and sex. Am J Epidemiol. 1973 Oct;98(4):289–300. doi: 10.1093/oxfordjournals.aje.a121558. [DOI] [PubMed] [Google Scholar]
  25. Parrott R. H., Kim H. W., Brandt C. D., Chanock R. M. Respiratory syncytial virus in infants and children. Prev Med. 1974 Dec;3(4):473–480. doi: 10.1016/0091-7435(74)90010-3. [DOI] [PubMed] [Google Scholar]
  26. Suto T., Yano N., Ikeda M., Miyamoto M., Takai S., Shigeta S., Hinuma Y., Ishida N. Respiratory syncytial virus infection and its serologic epidemiology. Am J Epidemiol. 1965 Nov;82(3):211–224. doi: 10.1093/oxfordjournals.aje.a120545. [DOI] [PubMed] [Google Scholar]
  27. Weightman D., Downham M. A., Gardner P. S. Introduction of a cross-infection rate in children's wards and its application to respiratory virus infections. J Hyg (Lond) 1974 Aug;73(1):53–60. doi: 10.1017/s0022172400023846. [DOI] [PMC free article] [PubMed] [Google Scholar]

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