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. 1982 May-Aug;55(3-4):259–264.

Infectious mononucleosis: observations on transmission.

J C Niederman
PMCID: PMC2596461  PMID: 6295004

Abstract

Epsten-Barr virus oropharyngeal shedding has been demonstrated in infectious mononucleosis patients many months after acute illness and long after the disease hallmarks, atypical lymphocytes and heterophile antibody, have disappeared. Extracellular virus is present more frequently in saliva than in other oropharyngeal samples. Prolonged excretion of EBV in asymptomatic carriers explains the difficulty in tracing case-to-case spread and increased transmissibility in age groups in which salivary exchange is high.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BUDDINGH G. J., SCHRUM D. I., LANIER J. C., GUIDRY D. J. Studies of the natural history of herpes simplex infections. Pediatrics. 1953 Jun;11(6):595–610. [PubMed] [Google Scholar]
  2. Biggar R. J., Henle W., Fleisher G., Böcker J., Lennette E. T., Henle G. Primary Epstein-Barr virus infections in African infants. I. Decline of maternal antibodies and time of infection. Int J Cancer. 1978 Sep 15;22(3):239–243. doi: 10.1002/ijc.2910220304. [DOI] [PubMed] [Google Scholar]
  3. Blacklow N. R., Watson B. K., Miller G., Jacobson B. M. Mononucleosis with heterophil antibodies and EB virus infection. Acquisition by an elderly patient in hospital. Am J Med. 1971 Oct;51(4):549–552. doi: 10.1016/0002-9343(71)90260-9. [DOI] [PubMed] [Google Scholar]
  4. Chang R. S., Golden H. D. Transformation of human leucocytes by throat washing from infectious mononucleosis patients. Nature. 1971 Dec 10;234(5328):359–360. doi: 10.1038/234359a0. [DOI] [PubMed] [Google Scholar]
  5. Evans A. S., Niederman J. C., McCollum R. W. Seroepidemiologic studies of infectious mononucleosis with EB virus. N Engl J Med. 1968 Nov 21;279(21):1121–1127. doi: 10.1056/NEJM196811212792101. [DOI] [PubMed] [Google Scholar]
  6. Gerber P., Lucas S., Nonoyama M., Perlin E., Goldstein L. I. Oral excretion of Epstein-Barr virus by healthy subjects and patients with infectious mononucleosis. Lancet. 1972 Nov 11;2(7785):988–989. doi: 10.1016/s0140-6736(72)92402-6. [DOI] [PubMed] [Google Scholar]
  7. HOAGLAND R. J. The transmission of infectious mononucleosis. Am J Med Sci. 1955 Mar;229(3):262–272. doi: 10.1097/00000441-195503000-00003. [DOI] [PubMed] [Google Scholar]
  8. Hallee T. J., Evans A. S., Niederman J. C., Brooks C. M., Voegtly j. H. Infectious mononucleosis at the United States Military Academy. A prospective study of a single class over four years. Yale J Biol Med. 1974 Sep;47(3):182–195. [PMC free article] [PubMed] [Google Scholar]
  9. Henle G., Henle W., Diehl V. Relation of Burkitt's tumor-associated herpes-ytpe virus to infectious mononucleosis. Proc Natl Acad Sci U S A. 1968 Jan;59(1):94–101. doi: 10.1073/pnas.59.1.94. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Henle G., Henle W. Observations on childhood infections with the Epstein-Barr virus. J Infect Dis. 1970 Mar;121(3):303–310. doi: 10.1093/infdis/121.3.303. [DOI] [PubMed] [Google Scholar]
  11. Joncas J., Mitnyan C. Serological response of the EBV antibodies in pediatric cases of infectious mononucleosis and in their contacts. Can Med Assoc J. 1970 Jun 6;102(12):1260–1263. [PMC free article] [PubMed] [Google Scholar]
  12. Lang D. J., Garruto R. M., Gajdusek D. C. Early acquisition of cytomegalovirus and Epstein-Barr virus antibody in several isolated Melanesian populations. Am J Epidemiol. 1977 May;105(5):480–487. doi: 10.1093/oxfordjournals.aje.a112407. [DOI] [PubMed] [Google Scholar]
  13. Lemon S. M., Hutt L. M., Shaw J. E., Li J. L., Pagano J. S. Replication of EBV in epithelial cells during infectious mononucleosis. Nature. 1977 Jul 21;268(5617):268–270. doi: 10.1038/268268a0. [DOI] [PubMed] [Google Scholar]
  14. Lipman M., Andrews L., Niederman J., Miller G. Direct visualization of enveloped Epstein-Barr Herpesvirus in throat washing with leukocyte-transforming activity. J Infect Dis. 1975 Nov;132(5):520–523. doi: 10.1093/infdis/132.5.520. [DOI] [PubMed] [Google Scholar]
  15. Miller G., Niederman J. C., Andrews L. L. Prolonged oropharyngeal excretion of Epstein-Barr virus after infectious mononucleosis. N Engl J Med. 1973 Feb 1;288(5):229–232. doi: 10.1056/NEJM197302012880503. [DOI] [PubMed] [Google Scholar]
  16. Morgan D. G., Niederman J. C., Miller G., Smith H. W., Dowaliby J. M. Site of Epstein-Barr virus replication in the oropharynx. Lancet. 1979 Dec 1;2(8153):1154–1157. doi: 10.1016/s0140-6736(79)92384-5. [DOI] [PubMed] [Google Scholar]
  17. Niederman J. C., Evans A. S., Subrahmanyan L., McCollum R. W. Prevalence, incidence and persistence of EB virus antibody in young adults. N Engl J Med. 1970 Feb 12;282(7):361–365. doi: 10.1056/NEJM197002122820704. [DOI] [PubMed] [Google Scholar]
  18. Niederman J. C., McCollum R. W., Henle G., Henle W. Infectious mononucleosis. Clinical manifestations in relation to EB virus antibodies. JAMA. 1968 Jan 15;203(3):205–209. doi: 10.1001/jama.203.3.205. [DOI] [PubMed] [Google Scholar]
  19. Niederman J. C., Miller G., Pearson H. A., Pagano J. S., Dowaliby J. M. Infectious mononucleosis. Epstein-Barr-virus shedding in saliva and the oropharynx. N Engl J Med. 1976 Jun 17;294(25):1355–1359. doi: 10.1056/NEJM197606172942501. [DOI] [PubMed] [Google Scholar]
  20. Pereira M. S., Field A. M., Blake J. M., Rodgers F. G., Bailey L. A., Davies J. R. Evidence for oral excretion of E.B. virus in infectious mononucleosis. Lancet. 1972 Apr 1;1(7753):710–711. doi: 10.1016/s0140-6736(72)90229-2. [DOI] [PubMed] [Google Scholar]
  21. Sawyer R. N., Evans A. S., Niederman J. C., McCollum R. W. Prospective studies of a group of Yale University freshmen. I. Occurrence of infectious mononucleosis. J Infect Dis. 1971 Mar;123(3):263–270. doi: 10.1093/infdis/123.3.263. [DOI] [PubMed] [Google Scholar]
  22. Strauch B., Andrews L. L., Siegel N., Miller G. Oropharyngeal excretion of Epstein-Barr virus by renal transplant recipients and other patients treated with immunosuppressive drugs. Lancet. 1974 Feb 16;1(7851):234–237. doi: 10.1016/s0140-6736(74)92546-x. [DOI] [PubMed] [Google Scholar]
  23. Sullivan J. L., Wallen W. C., Johnson F. L. Epstein-Barr virus infection following bone-marrow transplantation. Int J Cancer. 1978 Aug 15;22(2):132–135. doi: 10.1002/ijc.2910220205. [DOI] [PubMed] [Google Scholar]
  24. Turner A. R., MacDonald R. N., Cooper B. A. Transmission of infectious mononucleosis by transfusion of pre-illness plasma. Ann Intern Med. 1972 Nov;77(5):751–753. doi: 10.7326/0003-4819-77-5-751. [DOI] [PubMed] [Google Scholar]
  25. Visintine A. M., Gerber P., Nahmias A. J. Leukocyte transforming agent (Epstein-Barr virus) in newborn infants and older individuals. J Pediatr. 1976 Oct;89(4):571–575. doi: 10.1016/s0022-3476(76)80388-5. [DOI] [PubMed] [Google Scholar]

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