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. 1988 Dec;56(12):3116–3120. doi: 10.1128/iai.56.12.3116-3120.1988

Augmentation of host resistance to microbial infections by recombinant human interleukin-1 alpha.

A Minami 1, K Fujimoto 1, Y Ozaki 1, S Nakamura 1
PMCID: PMC259710  PMID: 3263325

Abstract

Recombinant human interleukin-1 alpha augmented resistance of mice to microbial infections caused by Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus, Streptococcus pneumoniae, Salmonella typhimurium, and Candida albicans. The effective doses of interleukin-1 alpha ranged from 0.01 to 10 micrograms per mouse, depending on the infecting organism, route of administration, and challenge dose. Intravenous interleukin-1 alpha was, dose for dose, more effective than intravenous muramyl dipeptide and lentinan against the P. aeruginosa and K. pneumoniae infections. Augmentation by interleukin-1 alpha of resistance to infection was also observed in P. aeruginosa-infected mice in a state of cyclophosphamide-induced leucopenia. Interleukin-1 alpha may be useful for controlling obstinate infections not curable by antimicrobial agents alone.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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