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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: Structure. 2008 Nov 12;16(11):1689–1701. doi: 10.1016/j.str.2008.09.005

Figure 1. NBD-556 enhancement of infection of CD4-negative cells by viruses with envelope glycoproteins from different HIV-1 strains.

Figure 1

Figure 1

a. The effect of incubating recombinant, luciferase-expressing HIV-1 bearing the envelope glycoproteins of the indicated HIV-1 strains with increasing concentrations of NBD-556 on infection of CD4-negative Cf2Th-CCR5 cells is shown. Relative virus infectivity represents the amount of infection detected in the presence of the indicated concentration of compound divided by the infection detected in the absence of compound. A recombinant HIV-1 with the A-MLV envelope glycoproteins is included as a control. The values shown are the means+/−SEM from a single experiment (n=3). The experiment was performed three times, with comparable results. b. The effect of incubating recombinant HIV-1 bearing the YU2, HXBc2 or HX(YU2 V3) envelope glycoproteins with increasing concentrations of NBD-556 on infection of Cf2Th-CCR5 cells is shown. The values shown are the means+/−SEM from a single experiment (n=3). The experiment was performed four times, with similar results.