Table 1.

Fibrosis Scoring Systems

Ishak Score
0	No fibrosis
1	Fibrous expansion of some portal areas, with or without short septae
2	Fibrous expansion of most portal areas, with or without short septae
3	Fibrous expansion of most portal areas with occasional portal to portal (P-P) and/or portal to central (P-C) bridging
4	Fibrous expansion of portal areas with marked bridging (P-P as well as P-C)
5	Marked bridging (P-P as well as P-C) with occasional nodules (incomplete cirrhosis)
6	Cirrhosis (probable or definite)
PBC Stage
1	No fibrosis. (There had to be some portal inflammation on the initial biopsy in order to be enrolled).
2	Non- bridging fibrosis. (Portal tracts expanded beyond the limiting plate with any degree of fibrosis less than stage 3.)
3	Bridging fibrosis (Two or more portal-portal bridges)
4	Cirrhosis (at least one regenerative nodule surrounded by fibrosis)