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. 1988 Dec;56(12):3313–3315. doi: 10.1128/iai.56.12.3313-3315.1988

Expression of tumor necrosis factor in vitro by human mononuclear phagocytes stimulated with whole Mycobacterium bovis BCG and mycobacterial antigens.

S E Valone 1, E A Rich 1, R S Wallis 1, J J Ellner 1
PMCID: PMC259742  PMID: 3053456

Abstract

Four mycobacterial preparations directly stimulated human blood monocytes and alveolar macrophages to produce tumor necrosis factor (TNF). Monoclonal antibody against TNF blocked (99%) TNF activity. Lipopolysaccharide was not responsible for the TNF activity generated; activity was unaffected in the presence of polymyxin B.

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Selected References

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