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. 1989 Nov;57(11):3383–3388. doi: 10.1128/iai.57.11.3383-3388.1989

Interleukin-6 induced at mucosal surfaces by gram-negative bacterial infection.

P de Man 1, C van Kooten 1, L Aarden 1, I Engberg 1, H Linder 1, C Svanborg Edén 1
PMCID: PMC259830  PMID: 2680971

Abstract

Interleukin-6 (IL-6) was produced in response to mucosal and systemic infection of mice with gram-negative bacteria. The IL-6 response was controlled by the lipopolysaccharide gene, Lps; in C3H/HeN mice (Lpsn/Lpsn), the urinary IL-6 levels increased within 30 min after challenge with Escherichia coli, but no response occurred in C3H/HeJ mice (Lpsd/Lpsd). In lipopolysaccharide-responder mice, the levels of local and systemic IL-6 were related to the degree of infection. The urinary response dominated after intravesical challenge, and the serum response dominated after intraperitoneal challenge. The results demonstrate that IL-6 is activated as part of lipopolysaccharide-induced mucosal and systemic responses to gram-negative bacterial infections.

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Selected References

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