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. 1988 May;56(5):1399–1401. doi: 10.1128/iai.56.5.1399-1401.1988

Resistance to infection with Eimeria vermiformis in mouse radiation chimeras is determined by donor bone-marrow cells.

H S Joysey 1, D Wakelin 1, M E Rose 1
PMCID: PMC259846  PMID: 3281912

Abstract

The course of infection with Eimeria vermiformis was determined in BALB/b, BALB/c, and C57BL/10ScSn (B10) mice and in radiation chimeras prepared from the H-2-compatible BALB/b and B10 mice. The BALB strains, irrespective of H-2 haplotype, were resistant, the B10 mice were susceptible, and in the chimeras infection was characterized by the genotype of the donated bone-marrow cells and not by the phenotype of the recipient. Thus, the genetic control of relative resistance or susceptibility to infection with this parasite is expressed through bone-marrow-derived cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Hormaeche C. E. The natural resistance of radiation chimeras to S. typhimurium C5. Immunology. 1979 Jun;37(2):329–332. [PMC free article] [PubMed] [Google Scholar]
  2. Howard J. G., Hale C., Liew F. Y. Genetically determined susceptibility to Leishmania tropica infection is expressed by haematopoietic donor cells in mouse radiation chimaeras. Nature. 1980 Nov 13;288(5787):161–162. doi: 10.1038/288161a0. [DOI] [PubMed] [Google Scholar]
  3. Klesius P. H., Hinds S. E. Strain-dependent differences in murine susceptibility to coccidia. Infect Immun. 1979 Dec;26(3):1111–1115. doi: 10.1128/iai.26.3.1111-1115.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Kongshavn P. A., Sadarangani C., Skamene E. Genetically determined differences in antibacterial activity of macrophages are expressed in the environment in which the macrophage precursors mature. Cell Immunol. 1980 Aug 1;53(2):341–349. doi: 10.1016/0008-8749(80)90334-2. [DOI] [PubMed] [Google Scholar]
  5. Mesfin G. M., Bellamy J. E. Thymic dependence of immunity to Eimeria falciformis var. pragensis in mice. Infect Immun. 1979 Feb;23(2):460–464. doi: 10.1128/iai.23.2.460-464.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Miller L. H., Carter R. A review. Innate resistance in malaria. Exp Parasitol. 1976 Aug;40(1):132–146. doi: 10.1016/0014-4894(76)90075-8. [DOI] [PubMed] [Google Scholar]
  7. Onoé K., Fernandes G., Good R. A. Humoral and cell-mediated immune responses in fully allogeneic bone marrow chimera in mice. J Exp Med. 1980 Jan 1;151(1):115–132. doi: 10.1084/jem.151.1.115. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Rose M. E., Millard B. J. Eimeria vermiformis: host strains and the developmental cycle. Exp Parasitol. 1985 Dec;60(3):285–293. doi: 10.1016/0014-4894(85)90033-5. [DOI] [PubMed] [Google Scholar]
  9. Rose M. E., Owen D. G., Hesketh P. Susceptibility to coccidiosis: effect of strain of mouse on reproduction of Eimeria vermiformis. Parasitology. 1984 Feb;88(Pt 1):45–54. doi: 10.1017/s0031182000054330. [DOI] [PubMed] [Google Scholar]
  10. Rose M. E., Wakelin D., Hesketh P. Susceptibility to coccidiosis: contrasting course of primary infections with Eimeria vermiformis in BALB/c and C57/BL/6 mice is based on immune responses. Parasite Immunol. 1985 Sep;7(5):557–566. doi: 10.1111/j.1365-3024.1985.tb00099.x. [DOI] [PubMed] [Google Scholar]
  11. Wakelin D., Donachie A. M. Genetic control of immunity to Trichinella spiralis. Donor bone marrow cells determine responses to infection in mouse radiation chimaeras. Immunology. 1981 Aug;43(4):787–792. [PMC free article] [PubMed] [Google Scholar]

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