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. 1987 Nov;55(11):2653–2657. doi: 10.1128/iai.55.11.2653-2657.1987

Effect of vaccination on feline Chlamydia psittaci infection.

J M Wills 1, T J Gruffydd-Jones 1, S J Richmond 1, R M Gaskell 1, F J Bourne 1
PMCID: PMC259956  PMID: 3666957

Abstract

Experimental ocular infection of specific-pathogen-free cats with the feline pneumonitis strain of Chlamydia psittaci produced an acute, severe conjunctivitis characterized by blepharospasm, conjunctival hyperemia, chemosis, and ocular discharge. Organisms were recovered from the conjunctiva for several weeks, and persistent genital and gastrointestinal infection also resulted from the ocular infection in some cats. Subcutaneous vaccination with live feline pneumonitis C. psittaci 4 weeks before ocular challenge significantly reduced the severity of the conjunctivitis. However, there was no effect on shedding of organisms from the eye or on the transmission of infection to the gastrointestinal and genital tracts. It is suggested that the acute stage of this ocular disease is caused largely by release of pathogenic antigen(s) from chlamydia-infected conjunctival cells, rather than by a direct cytopathic effect of chlamydial replication. Thus, vaccination with whole live organisms reduced the acute disease in experimentally infected cats but did not prevent shedding of the organism. The implications of these findings are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baker J. A. A VIRUS OBTAINED FROM A PNEUMONIA OF CATS AND ITS POSSIBLE RELATION TO THE CAUSE OF ATYPICAL PNEUMONIA IN MAN. Science. 1942 Nov 20;96(2499):475–476. doi: 10.1126/science.96.2499.475. [DOI] [PubMed] [Google Scholar]
  2. Cello R. M. Microbiological and immunologic aspects of feline pneumonitis. J Am Vet Med Assoc. 1971 Mar 15;158(6 Suppl):932–938. [PubMed] [Google Scholar]
  3. Cello R. M. Ocular infections in animals with PLT (Bedsonia) group agents. Am J Ophthalmol. 1967 May;63(5 Suppl):1270–1274. doi: 10.1016/0002-9394(67)94109-8. [DOI] [PubMed] [Google Scholar]
  4. Gaillard E. T., Hargis A. M., Prieur D. J., Evermann J. F., Dhillon A. S. Pathogenesis of feline gastric chlamydial infection. Am J Vet Res. 1984 Nov;45(11):2314–2321. [PubMed] [Google Scholar]
  5. Hargis A. M., Prieur D. J., Gaillard E. T. Chlamydial infection of the gastric mucosa in twelve cats. Vet Pathol. 1983 Mar;20(2):170–178. doi: 10.1177/030098588302000204. [DOI] [PubMed] [Google Scholar]
  6. Hoover E. A., Kahn D. E., Langloss J. M. Experimentally induced feline chlamydial infection (feline pneumonitis). Am J Vet Res. 1978 Apr;39(4):541–547. [PubMed] [Google Scholar]
  7. Johnson F. W. Isolation of Chlamydia psittaci from nasal and conjunctival exudate of a domestic cat. Vet Rec. 1984 Apr 7;114(14):342–344. doi: 10.1136/vr.114.14.342. [DOI] [PubMed] [Google Scholar]
  8. Kane J. L., Woodland R. M., Elder M. G., Darougar S. Chlamydial pelvic infection in cats: a model for the study of human pelvic inflammatory disease. Genitourin Med. 1985 Oct;61(5):311–318. doi: 10.1136/sti.61.5.311. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. MCKERCHER D. G. Feline pneumonitis. I. Immunization studies in kittens. Am J Vet Res. 1952 Oct;13(49):557–561. [PubMed] [Google Scholar]
  10. Mitzel J. R., Strating A. Vaccination against feline pneumonitis. Am J Vet Res. 1977 Sep;38(9):1361–1363. [PubMed] [Google Scholar]
  11. Monnickendam M. A., Pearce J. H. Immune responses and chlamydial infections. Br Med Bull. 1983 Apr;39(2):187–193. doi: 10.1093/oxfordjournals.bmb.a071814. [DOI] [PubMed] [Google Scholar]
  12. Mount D. T., Bigazzi P. E., Barron A. L. Infection of genital tract and transmission of ocular infection to newborns by the agent of guinea pig inclusion conjunctivitis. Infect Immun. 1972 Jun;5(6):921–926. doi: 10.1128/iai.5.6.921-926.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Povey R. C., Johnson R. H. A survey of feline viral rhinotracheitis and feline picornavirus infection in Britain. J Small Anim Pract. 1971 Apr;12(4):233–247. doi: 10.1111/j.1748-5827.1971.tb06226.x. [DOI] [PubMed] [Google Scholar]
  14. Richmond S. J., Stirling P. Localization of chlamydial group Antigen in McCoy cell monolayers infected with Chlamydia trachomatis or Chlamydia psittaci. Infect Immun. 1981 Nov;34(2):561–570. doi: 10.1128/iai.34.2.561-570.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Richmond S. J. The isolation of Chlamydia subgroup A (Chlamydia trachomatis) in irradiated McCoy cells. Med Lab Technol. 1974 Jan;31(1):7–9. [PubMed] [Google Scholar]
  16. Shewen P. E., Povey R. C., Wilson M. R. A comparison of the efficacy of a live and four inactivated vaccine preparations for the protection of cats against experimental challenge with Chlamydia psittaci. Can J Comp Med. 1980 Jul;44(3):244–251. [PMC free article] [PubMed] [Google Scholar]
  17. Shewen P. E., Povey R. C., Wilson M. R. Case report. Feline chlamydial infection. Can Vet J. 1978 Oct;19(10):289–292. [PMC free article] [PubMed] [Google Scholar]
  18. Spears P., Storz J. Biotyping of Chlamydia psittaci based on inclusion morphology and response to diethylaminoethyl-dextran and cycloheximide. Infect Immun. 1979 Apr;24(1):224–232. doi: 10.1128/iai.24.1.224-232.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Spencer W. N., Johnson F. W. Simple transport medium for the isolation of Chlamydia psittaci from clinical material. Vet Rec. 1983 Dec 3;113(23):535–536. [PubMed] [Google Scholar]
  20. Studdert M. J., Studdert V. P., Wirth H. J. Isolation of Chlamydia psittaci from cats with conjunctivitis. Aust Vet J. 1981 Nov;57(11):515–517. doi: 10.1111/j.1751-0813.1981.tb05787.x. [DOI] [PubMed] [Google Scholar]
  21. Taylor-Robinson D., Thomas B. J. The rôle of Chlamydia trachomatis in genital-tract and associated diseases. J Clin Pathol. 1980 Mar;33(3):205–233. doi: 10.1136/jcp.33.3.205. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Wills J., Gruffydd-Jones T. J., Richmond S., Paul I. D. Isolation of Chlamydia psittaci from cases of conjunctivitis in a colony of cats. Vet Rec. 1984 Apr 7;114(14):344–346. doi: 10.1136/vr.114.14.344. [DOI] [PubMed] [Google Scholar]

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