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. 1986 Nov;54(2):339–346. doi: 10.1128/iai.54.2.339-346.1986

Immune response of athymic and euthymic germfree mice to Campylobacter spp.

J W Yrios, E Balish
PMCID: PMC260166  PMID: 3533777

Abstract

Pure cultures of several Campylobacter spp. induced a specific humoral immune response after they colonized and infected gnotobiotic mice; however, Campylobacter-immune mouse serum was not bactericidal (in vitro), manifested a weak agglutination reaction (in vitro), and showed specificity (strain 45100-immune mouse sera) for the homologous (infecting) Campylobacter strain, but was not able to passively protect germfree athymic (nu/nu) BALB/c mice against Campylobacter infection and diarrhea. Active immunization of germfree nu/nu mice with Formalin-killed C. jejuni also did not protect the gnotobiotic mice from Campylobacter infection and diarrhea. It appears from the results of our initial gnotobiotic studies that antibodies in serum against the infecting strain of C. jejuni may not play an essential role in resistance to Campylobacter disease in mice.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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