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. 1986 Nov;54(2):516–521. doi: 10.1128/iai.54.2.516-521.1986

Modulation of Actinomyces viscosus colonization of mouse teeth in vivo by immunization with fimbrial adhesins.

P C Crawford, W B Clark
PMCID: PMC260191  PMID: 2876963

Abstract

Experiments were performed to determine whether immunization of mice with fimbrial adhesins isolated from Actinomyces viscosus T14V could modulate infection of tooth surfaces in animals challenged with the homologous strain. Saliva and sera from animals immunized in the submandibular gland region contained elevated levels of fimbria-specific immunoglobulin A (IgA) and IgG, whereas saliva and sera from sham-immunized animals did not. There was a statistically significant inverse correlation between the presence of fimbria-specific antibodies in saliva and serum and the levels of bacterial colonization on molar tooth surfaces. These results suggest that fimbrial adhesins may effectively modulate infection of tooth surfaces by periodontopathic bacteria.

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Selected References

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