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. 1986 Nov;54(2):543–548. doi: 10.1128/iai.54.2.543-548.1986

Strong mitogenic effect for murine B lymphocytes of an immunosuppressor substance released by Streptococcus intermedius.

M P Arala-Chaves, A S Ribeiro, M M Santarém, A Coutinho
PMCID: PMC260195  PMID: 3490441

Abstract

A noncytotoxic protein substance, produced by Streptococcus intermedius, with very potent immunosuppressive properties (F3'EP-Si) was tested for lymphocyte mitogenic activity. Although devoid of T-cell mitogenicity, F3'EP-Si stimulated proliferation and led to high numbers of plaque-forming cells in cultures of normal or T-cell-depleted, small or large splenic B cells from both lipopolysaccharide-responding and -nonresponding mice. The B-cell mitogenic activity of F3'EP-Si was quantitatively comparable to that of lipopolysaccharide, and the simultaneous exposure to both mitogens stimulated additive B-cell responses. Injection of F3'EP-Si into normal mice resulted in increased numbers of spleen cells, higher rates of mitotic activity, and very large numbers of plaque-forming cells, predominantly of the immunoglobulin G2a and -b isotypes. In preliminary experiments, the analysis of surface markers among the lymphocytes participating in the blastogenic response in vivo revealed a T-cell component in the response to F3'EP-Si. These observations are discussed in the context of the immunosuppressive activity of this and other microbial substances.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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