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. 1987 Mar;55(3):816–821. doi: 10.1128/iai.55.3.816-821.1987

Protective immunity induced by outer membrane proteins of Salmonella typhimurium in mice.

V Udhayakumar, V R Muthukkaruppan
PMCID: PMC260415  PMID: 3546142

Abstract

Outer membrane proteins (OMP) extracted from both smooth (C5) and rough (Rb2) strains of Salmonella typhimurium were able to induce protective immunity to salmonellosis. The OMP-induced protection lasted for at least 6 months. The antibody level was estimated by passive hemagglutination. In the C5 OMP-immunized mice, antibodies to both proteins and lipopolysaccharide were detected. On the other hand, in the Rb2 OMP-immunized mice, antiprotein but not antilipopolysaccharide antibodies were detected. Delayed-type hypersensitivity appeared as early as the second week after immunization with OMP and persisted through the fourth week.

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Selected References

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