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. 1987 Apr;55(4):1014–1016. doi: 10.1128/iai.55.4.1014-1016.1987

Inhibition of the intracellular growth of Histoplasma capsulatum by recombinant murine gamma interferon.

B A Wu-Hsieh, D H Howard
PMCID: PMC260455  PMID: 3104206

Abstract

Recombinant murine gamma interferon as well as lymphokines prepared from immune splenocytes and concanavalin A-stimulated T-cell hybridoma activated normal mouse peritoneal macrophages to inhibit the intracellular growth of Histoplasma capsulatum. The activities of the lymphokine from immune splenocytes and of recombinant murine gamma interferon were neutralized by rabbit anti-murine gamma interferon antibody. The intracellular yeasts were not killed by the interaction even though growth was completely inhibited.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beaman L., Benjamini E., Pappagianis D. Activation of macrophages by lymphokines: enhancement of phagosome-lysosome fusion and killing of Coccidioides immitis. Infect Immun. 1983 Mar;39(3):1201–1207. doi: 10.1128/iai.39.3.1201-1207.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Cole P. Activation of mouse peritoneal cells to kill Listeria monocytogenes by T-lymphocyte products. Infect Immun. 1975 Jul;12(1):36–41. doi: 10.1128/iai.12.1.36-41.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. HOWARD D. H. INTRACELLULAR GROWTH OF HISTOPLASMA CAPSULATUM. J Bacteriol. 1965 Feb;89:518–523. doi: 10.1128/jb.89.2.518-523.1965. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Haidaris C. G., Bonventre P. F. Elimination of Leishmania donovani amastigotes by activated macrophages. Infect Immun. 1981 Sep;33(3):918–926. doi: 10.1128/iai.33.3.918-926.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hoover D. L., Finbloom D. S., Crawford R. M., Nacy C. A., Gilbreath M., Meltzer M. S. A lymphokine distinct from interferon-gamma that activates human monocytes to kill Leishmania donovani in vitro. J Immunol. 1986 Feb 15;136(4):1329–1333. [PubMed] [Google Scholar]
  6. Howard D. H. Comparative sensitivity of Histoplasma capsulatum conidiospores and blastospores to oxidative antifungal systems. Infect Immun. 1981 Apr;32(1):381–387. doi: 10.1128/iai.32.1.381-387.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Howard D. H., Otto V., Gupta R. K. Lymphocyte-mediated cellular immunity in histoplasmosis. Infect Immun. 1971 Nov;4(5):605–610. doi: 10.1128/iai.4.5.605-610.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Lee J. C., Rebar L., Young P., Ruscetti F. W., Hanna N., Poste G. Identification and characterization of a human T cell line-derived lymphokine with MAF-like activity distinct from interferon-gamma. J Immunol. 1986 Feb 15;136(4):1322–1328. [PubMed] [Google Scholar]
  9. McDaniel L. S., Cozad G. C. Immunomodulation by Blastomyces dermatitidis: functional activity of murine peritoneal macrophages. Infect Immun. 1983 May;40(2):733–740. doi: 10.1128/iai.40.2.733-740.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Murray H. W. Interaction of Leishmania with a macrophage cell line. Correlation between intracellular killing and the generation of oxygen intermediates. J Exp Med. 1981 Jun 1;153(6):1690–1695. doi: 10.1084/jem.153.6.1690. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Nacy C. A., Fortier A. H., Meltzer M. S., Buchmeier N. A., Schreiber R. D. Macrophage activation to kill Leishmania major: activation of macrophages for intracellular destruction of amastigotes can be induced by both recombinant interferon-gamma and non-interferon lymphokines. J Immunol. 1985 Nov;135(5):3505–3511. [PubMed] [Google Scholar]
  12. Nacy C. A., Meltzer M. S., Leonard E. J., Wyler D. J. Intracellular replication and lymphokine-induced destruction of Leishmania tropica in C3H/HeN mouse macrophages. J Immunol. 1981 Dec;127(6):2381–2386. [PubMed] [Google Scholar]
  13. Nacy C. A., Meltzer M. S. Macrophages in resistance to rickettsial infection: macrophage activation in vitro for killing of Rickettsia tsutsugamushi. J Immunol. 1979 Dec;123(6):2544–2549. [PubMed] [Google Scholar]
  14. Nogueira N., Cohn Z. A. Trypanosoma cruzi: in vitro induction of macrophage microbicidal activity. J Exp Med. 1978 Jul 1;148(1):288–300. doi: 10.1084/jem.148.1.288. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Pfefferkorn E. R., Guyre P. M. Inhibition of growth of Toxoplasma gondii in cultured fibroblasts by human recombinant gamma interferon. Infect Immun. 1984 May;44(2):211–216. doi: 10.1128/iai.44.2.211-216.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Sibley L. D., Krahenbuhl J. L., Weidner E. Lymphokine activation of J774G8 cells and mouse peritoneal macrophages challenged with Toxoplasma gondii. Infect Immun. 1985 Sep;49(3):760–764. doi: 10.1128/iai.49.3.760-764.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Wu-Hsieh B., Howard D. H. Inhibition of growth of Histoplasma capsulatum by lymphokine-stimulated macrophages. J Immunol. 1984 May;132(5):2593–2597. [PubMed] [Google Scholar]
  18. Wu-Hsieh B., Zlotnik A., Howard D. H. T-cell hybridoma-produced lymphokine that activates macrophages to suppress intracellular growth of Histoplasma capsulatum. Infect Immun. 1984 Jan;43(1):380–385. doi: 10.1128/iai.43.1.380-385.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Zlotnik A., Roberts W. K., Vasil A., Blumenthal E., Larosa F., Leibson H. J., Endres R. O., Graham S. D., Jr, White J., Hill J. Coordinate production by a T cell hybridoma of gamma interferon and three other lymphokine activities: multiple activities of a single lymphokine? J Immunol. 1983 Aug;131(2):794–800. [PubMed] [Google Scholar]

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