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. 1987 May;55(5):1132–1136. doi: 10.1128/iai.55.5.1132-1136.1987

Immune response to the B oligomer of pertussis toxin.

J L Arciniega, D L Burns, E Garcia-Ortigoza, C R Manclark
PMCID: PMC260480  PMID: 3570457

Abstract

Immunization of mice with the B oligomer of pertussis toxin induced antibodies to the native toxin as measured by an enzyme-linked immunosorbent assay. These antibodies neutralized the ability of pertussis toxin to alter the morphology of Chinese hamster ovary cells. Furthermore, mice immunized with the B oligomer, when challenged with pertussis toxin, did not exhibit the leukocytosis normally associated with exposure to the toxin. These results demonstrate that the B oligomer, which does not contain the enzymatic activity of the holotoxin, can be used to induce a neutralizing antibody response and suggest that the B oligomer might be considered for use in acellular pertussis vaccines.

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Selected References

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