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. 1987 Jun;55(6):1526–1528. doi: 10.1128/iai.55.6.1526-1528.1987

Elimination of group A streptococcal cell walls from mammalian tissues.

J Gilbart, A Fox
PMCID: PMC260547  PMID: 3553006

Abstract

The precise levels in mammalian tissues of rhamnose (a constituent of the group-specific polysaccharide) and muramic acid (a constituent of peptidoglycan) at various times after systemic administration of streptococcal cell walls were noted for the first time. The extreme resistance of the streptococcal cell wall to degradation by mammalian enzymes can now be clearly appreciated. The results help explain the chronic nature of certain inflammatory diseases elicited by streptococcal cell wall debris.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cromartie W. J., Craddock J. G., Schwab J. H., Anderle S. K., Yang C. H. Arthritis in rats after systemic injection of streptococcal cells or cell walls. J Exp Med. 1977 Dec 1;146(6):1585–1602. doi: 10.1084/jem.146.6.1585. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Eisenberg R., Fox A., Greenblatt J. J., Anderle S. K., Cromartie W. J., Schwab J. H. Measurement of bacterial cell wall in tissues by solid-phase radioimmunoassay: correlation of distribution and persistence with experimental arthritis in rats. Infect Immun. 1982 Oct;38(1):127–135. doi: 10.1128/iai.38.1.127-135.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Fox A., Brown R. R., Anderle S. K., Chetty C., Cromartie W. J., Gooder H., Schwab J. H. Arthropathic properties related to the molecular weight of peptidoglycan-polysaccharide polymers of streptococcal cell walls. Infect Immun. 1982 Mar;35(3):1003–1010. doi: 10.1128/iai.35.3.1003-1010.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Fox A., Schwab J. H., Cochran T. Muramic acid detection in mammalian tissues by gas-liquid chromatography-mass spectrometry. Infect Immun. 1980 Aug;29(2):526–531. doi: 10.1128/iai.29.2.526-531.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Gallis H. A., Miller S. E., Wheat R. W. Degradation of 14C-labeled streptococcal cell walls by egg white lysozyme and lysosomal enzymes. Infect Immun. 1976 May;13(5):1459–1466. doi: 10.1128/iai.13.5.1459-1466.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Harrison J., Fox A. Degradation of muramyl dipeptide by mammalian serum. Infect Immun. 1985 Oct;50(1):320–321. doi: 10.1128/iai.50.1.320-321.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Janusz M. J., Chetty C., Eisenberg R. A., Cromartie W. J., Schwab J. H. Treatment of experimental erosive arthritis in rats by injection of the muralytic enzyme mutanolysin. J Exp Med. 1984 Nov 1;160(5):1360–1374. doi: 10.1084/jem.160.5.1360. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Ohanian S. H., Schwab J. H. Persistence of group a streptococcal cell walls related to chronic inflammation of rabbit dermal connective tissue. J Exp Med. 1967 Jun 1;125(6):1137–1148. doi: 10.1084/jem.125.6.1137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Parant M., Parant F., Chedid L., Yapo A., Petit J. F., Lederer E. Fate of the synthetic immunoadjuvant, muramyl dipeptide (14C-labelled) in the mouse. Int J Immunopharmacol. 1979;1(1):35–41. doi: 10.1016/0192-0561(79)90028-6. [DOI] [PubMed] [Google Scholar]
  10. Sartor R. B., Cromartie W. J., Powell D. W., Schwab J. H. Granulomatous enterocolitis induced in rats by purified bacterial cell wall fragments. Gastroenterology. 1985 Sep;89(3):587–595. doi: 10.1016/0016-5085(85)90455-x. [DOI] [PubMed] [Google Scholar]
  11. Stimpson S. A., Esser R. E., Cromartie W. J., Schwab J. H. Comparison of in vivo degradation of 125I-labeled peptidoglycan-polysaccharide fragments from group A and group D streptococci. Infect Immun. 1986 May;52(2):390–396. doi: 10.1128/iai.52.2.390-396.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Tomasić J., Ladesić B., Valinger Z., Hrsak I. The metabolic fate of 14C-labeled peptidoglycan monomer in mice. I. Identification of the monomer and the corresponding pentapeptide in urine. Biochim Biophys Acta. 1980 Apr 17;629(1):77–82. doi: 10.1016/0304-4165(80)90266-4. [DOI] [PubMed] [Google Scholar]
  13. Wells A., Pararajasegaram G., Baldwin M., Yang C. H., Hammer M., Fox A. Uveitis and arthritis induced by systemic injection of streptococcal cell walls. Invest Ophthalmol Vis Sci. 1986 Jun;27(6):921–925. [PubMed] [Google Scholar]
  14. Whiton R. S., Lau P., Morgan S. L., Gilbart J., Fox A. Modifications in the alditol acetate method for analysis of muramic acid and other neutral and amino sugars by capillary gas chromatography-mass spectrometry with selected ion monitoring. J Chromatogr. 1985 Oct 25;347(1):109–120. doi: 10.1016/s0021-9673(01)95474-3. [DOI] [PubMed] [Google Scholar]

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