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. 1987 Jul;55(7):1715–1717. doi: 10.1128/iai.55.7.1715-1717.1987

Enhanced endotoxin effects in plasma fibronectin-deficient rats.

M C Yoder, L Kilpatrick-Smith, D Arbittier, S D Douglas, R A Polin
PMCID: PMC260583  PMID: 3298066

Abstract

Immunoreactive plasma fibronectin depletion has been associated with the presence of collagen-fibronectin complexes in patients after trauma and in animal models of traumatic and burn injuries. However, the role of plasma fibronectin in the development of sepsis after traumatic and burn injuries in patients is unknown. Treatment of patients and animals with purified human plasma fibronectin ameliorates some of the clinical and metabolic effects of systemic endotoxemia. We report that the induction of immunoreactive plasma fibronectin deficiency by gelatin infusion is associated with enhanced effects of intraperitoneal Escherichia coli endotoxin injection. We have observed a significant increase in the concentrations of ammonia in plasma of treated rats compared with those in control rats administered the same dose of endotoxin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abraham E. Immunologic mechanisms underlying sepsis in the critically ill surgical patient. Surg Clin North Am. 1985 Aug;65(4):991–1003. doi: 10.1016/s0039-6109(16)43690-x. [DOI] [PubMed] [Google Scholar]
  2. Balian G., Click E. M., Crouch E., Davidson J. M., Bornstein P. Isolation of a collagen-binding fragment from fibronectin and cold-insoluble globulin. J Biol Chem. 1979 Mar 10;254(5):1429–1432. [PubMed] [Google Scholar]
  3. Deno D. C., McCafferty M. H., Saba T. M., Blumenstock F. A. Mechanism of acute depletion of plasma fibronectin following thermal injury in rats. Appearance of a gelatinlike ligand in plasma. J Clin Invest. 1984 Jan;73(1):20–34. doi: 10.1172/JCI111191. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Engvall E., Ruoslahti E., Miller E. J. Affinity of fibronectin to collagens of different genetic types and to fibrinogen. J Exp Med. 1978 Jun 1;147(6):1584–1595. doi: 10.1084/jem.147.6.1584. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Everett M. M., Hauptman J. G., Emerson T. E., Jr Effects of fibronectin pretreatment on cardiovascular, acid-base, metabolic, and organ function indices during endotoxin shock in the dog. Circ Shock. 1986;19(2):137–147. [PubMed] [Google Scholar]
  6. Ingham K. C., Brew S. A., Miekka S. I. Interaction of plasma fibronectin with gelatin and complement C1q. Mol Immunol. 1983 Mar;20(3):287–295. doi: 10.1016/0161-5890(83)90068-8. [DOI] [PubMed] [Google Scholar]
  7. Kiener J. L., Cho E., Saba T. M. Comparative effect of circulating bacterial or nonbacterial particulates on plasma fibronectin: relationship to lung deposition of blood-borne foreign particles. Circ Shock. 1986;19(4):357–370. [PubMed] [Google Scholar]
  8. Kilpatrick-Smith L., Yoder M. C., Polin R. A., Douglas S. D., Erecińska M. Endotoxin-induced changes in nitrogen metabolism. Res Commun Chem Pathol Pharmacol. 1986 Sep;53(3):381–398. [PubMed] [Google Scholar]
  9. Powell J. T., Poskitt K. R., Irwin J. T., Attanoos R. L., McCollum C. N. Opsonic dysfunction secondary to plasma fibronectin depletion after aortic surgery. Br J Surg. 1986 Jan;73(1):38–40. doi: 10.1002/bjs.1800730114. [DOI] [PubMed] [Google Scholar]
  10. Richards P. S., Saba T. M. Effect of endotoxin on fibronectin and Kupffer cell activity. Hepatology. 1985 Jan-Feb;5(1):32–37. doi: 10.1002/hep.1840050108. [DOI] [PubMed] [Google Scholar]
  11. Saba T. M., Blumenstock F. A., Scovill W. A., Bernard H. Cryoprecipitate reversal of opsonic alpha2-surface binding glycoprotein deficiency in septic surgical and trauma patients. Science. 1978 Aug 18;201(4356):622–624. doi: 10.1126/science.675246. [DOI] [PubMed] [Google Scholar]
  12. Saba T. M., Blumenstock F. A., Shah D. M., Kaplan J. E., Cho E., Scovill W., Stratton H., Newell J., Gottlieb M., Sedransk N. Reversal of fibronectin and opsonic deficiency in patients. A controlled study. Ann Surg. 1984 Jan;199(1):87–96. doi: 10.1097/00000658-198401000-00015. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Snyder E. L., Barash P. G., Mosher D. F., Walter S. D. Plasma fibronectin level and clinical status in cardiac surgery patients. J Lab Clin Med. 1983 Dec;102(6):881–889. [PubMed] [Google Scholar]
  14. TAPLIN G. V., JOHNSON D. E., DORE E. K., KAPLAN H. S. SUSPENSIONS OF RADIOALBUMIN AGGREGATES FOR PHOTOSCANNING THE LIVER, SPLEEN, LUNG AND OTHER ORGANS. J Nucl Med. 1964 Apr;5:259–275. [PubMed] [Google Scholar]
  15. Wilson R. F. Special problems in the diagnosis and treatment of surgical sepsis. Surg Clin North Am. 1985 Aug;65(4):965–989. doi: 10.1016/s0039-6109(16)43689-3. [DOI] [PubMed] [Google Scholar]
  16. Yoder M. C., Douglas S. D., Gerdes J., Kline J., Polin R. A. Plasma fibronectin in healthy newborn infants: respiratory distress syndrome and perinatal asphyxia. J Pediatr. 1983 May;102(5):777–780. doi: 10.1016/s0022-3476(83)80257-1. [DOI] [PubMed] [Google Scholar]
  17. Yoder M. C., Egler J. M., Yudkoff M., Chatten J., Douglas S. D., Polin R. A. Metabolic and mitochondrial morphological changes that mimic Reye syndrome after endotoxin administration to rats. Infect Immun. 1985 Jan;47(1):329–331. doi: 10.1128/iai.47.1.329-331.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]

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