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. 1987 Aug;55(8):1927–1928. doi: 10.1128/iai.55.8.1927-1928.1987

Resistance to meningococcemia apparently conferred by anti-H.8 monoclonal antibody is due to contaminating endotoxin and not to specific immunoprotection.

J P Woods, J R Black, D S Barritt, T D Connell, J G Cannon
PMCID: PMC260627  PMID: 3112017

Abstract

We evaluated the ability of a monoclonal antibody directed against the common H.8 antigen of pathogenic Neisseria sp. to confer passive protection against meningococcal disease in mice. The apparent protection conferred by antibody purified from tissue culture supernatant was actually the result of endotoxin contamination of buffers and tissue culture media. Endotoxin-free anti-H.8 antibody was not protective. The possibility of endotoxin contamination should be considered when evaluating immunity conferred by passively administered antibody in animal models.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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