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. Author manuscript; available in PMC: 2009 Sep 1.
Published in final edited form as: Neuropharmacology. 2008 Jun 27;55(4):500–508. doi: 10.1016/j.neuropharm.2008.06.039

Figure 5. Neuroprotective effects of glutamate in mouse cortical neurons.

Figure 5

a, Toxicity induced by adenoviral overexpression of mGlu1 (AdV), expressed as % of viability in untreated cells, is abolished by 1 mM glutamate (Glu), when tested in presence of inhibitors of ionotropic glutamate receptors 1 µM MK801 and 10 µM NBQX. b, Glutamate kills all cells in the absence of MK801 and NBQX, but provides a dose-dependent protection against toxicity induced by a 24h deprivation of B27 supplement (dashed line) when applied in the presence of 1µM MK801 and 10 µM NBQX. c, The protective effect of glutamate is abolished by the mGlu1 antagonist CPCCOEt but not by the mGlu5 antagonist MPEP. Data are means with error bars representing S.E.M. from at least three experiments. *p<0.05 and **p<0.001 as compared to glutamate-untreated control (a, b) or to glutamate alone (c) using Student’s t-test.