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. 1994 Oct;86(10):775–778.

Side effects and complications of treatment with desmopressin for enuresis.

W L Robson 1, A K Leung 1
PMCID: PMC2607707  PMID: 7807562

Abstract

A literature search revealed 23 studies that have reported on the type or frequency of side effects or complications associated with the use of desmopressin (DDAVP, Rhône-Poulenc Rorer Pharmaceuticals Inc, Collegeville, Pennsylvania) for the treatment of enuresis. Thirty-one (4.3%) side effects were reported in 717 patients. Seizure secondary to water intoxication is a potential complication of treatment with desmopressin and was reported in six patients, usually in association with excess fluid intake during the evening or day preceding the use of desmopressin. Desmopressin appears to have a favorable safety profile. Patients should be specifically instructed not to ingest excess fluids during the evening prior to administration of desmopressin.

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Selected References

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  1. Aladjem M., Wohl R., Boichis H., Orda S., Lotan D., Freedman S. Desmopressin in nocturnal enuresis. Arch Dis Child. 1982 Feb;57(2):137–140. doi: 10.1136/adc.57.2.137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bamford M. F., Cruickshank G. Dangers of intranasal desmopressin for nocturnal enuresis. J R Coll Gen Pract. 1989 Aug;39(325):345–346. [PMC free article] [PubMed] [Google Scholar]
  3. Beach P. S., Beach R. E., Smith L. R. Hyponatremic seizures in a child treated with desmopressin to control enuresis. A rational approach to fluid intake. Clin Pediatr (Phila) 1992 Sep;31(9):566–569. doi: 10.1177/000992289203100913. [DOI] [PubMed] [Google Scholar]
  4. Belmaker R. H., Bleich A. The use of desmopressin in adult enuresis. Mil Med. 1986 Dec;151(12):660–662. [PubMed] [Google Scholar]
  5. Birkásová M., Birkás O., Flynn M. J., Cort J. H. Desmopressin in the management of nocturnal enuresis in children: a double-blind study. Pediatrics. 1978 Dec;62(6):970–974. [PubMed] [Google Scholar]
  6. Blanchard P., Brossier J. P. Convulsions par hyponatrémie profonde au cours d'un traitement par desmopressine nasale pour énurésie. Arch Fr Pediatr. 1991 Oct;48(8):589–589. [PubMed] [Google Scholar]
  7. Davis R. C., Morris D. S., Briggs J. E. Nocturnal enuresis. Lancet. 1992 Dec 19;340(8834-8835):1550–1550. doi: 10.1016/0140-6736(92)92806-q. [DOI] [PubMed] [Google Scholar]
  8. Delaere K. P., Strijbos W. E. Antidiuretic approach with DDAVP for nocturnal enuresis. Acta Urol Belg. 1986;54(4):464–470. [PubMed] [Google Scholar]
  9. Dimson S. B. DDAVP and urine osmolality in refractory enuresis. Arch Dis Child. 1986 Nov;61(11):1104–1107. doi: 10.1136/adc.61.11.1104. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Dimson S. B. Desmopressin as a treatment for enuresis. Lancet. 1977 Jun 11;1(8024):1260–1260. doi: 10.1016/s0140-6736(77)92467-9. [DOI] [PubMed] [Google Scholar]
  11. Evans J. H., Meadow S. R. Desmopressin for bed wetting: length of treatment, vasopressin secretion, and response. Arch Dis Child. 1992 Feb;67(2):184–188. doi: 10.1136/adc.67.2.184. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Ferrie B. G., MacFarlane J., Glen E. S. DDAVP in young enuretic patients: a double-blind trial. Br J Urol. 1984 Aug;56(4):376–378. doi: 10.1111/j.1464-410x.1984.tb05824.x. [DOI] [PubMed] [Google Scholar]
  13. Fjellestad-Paulsen A., Wille S., Harris A. S. Comparison of intranasal and oral desmopressin for nocturnal enuresis. Arch Dis Child. 1987 Jul;62(7):674–677. doi: 10.1136/adc.62.7.674. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Harris A. S. Clinical experience with desmopressin: efficacy and safety in central diabetes insipidus and other conditions. J Pediatr. 1989 Apr;114(4 Pt 2):711–718. doi: 10.1016/s0022-3476(89)80886-8. [DOI] [PubMed] [Google Scholar]
  15. Hilton P., Stanton S. L. The use of desmopressin (DDAVP) in nocturnal urinary frequency in the female. Br J Urol. 1982 Jun;54(3):252–255. doi: 10.1111/j.1464-410x.1982.tb06969.x. [DOI] [PubMed] [Google Scholar]
  16. Janknegt R. A., Smans A. J. Treatment with desmopressin in severe nocturnal enuresis in childhood. Br J Urol. 1990 Nov;66(5):535–537. doi: 10.1111/j.1464-410x.1990.tb15005.x. [DOI] [PubMed] [Google Scholar]
  17. Key D. W., Bloom D. A., Sanvordenker J. Low-dose DDAVP in nocturnal enuresis. Clin Pediatr (Phila) 1992 May;31(5):299–301. doi: 10.1177/000992289203100507. [DOI] [PubMed] [Google Scholar]
  18. Knudsen U. B., Rittig S., Nørgaard J. P., Lundemose J. B., Pedersen E. B., Djurhuus J. C. Long-term treatment of nocturnal enuresis with desmopressin. A follow-up study. Urol Res. 1991;19(4):237–240. doi: 10.1007/BF00305302. [DOI] [PubMed] [Google Scholar]
  19. Miller K., Goldberg S., Atkin B. Nocturnal enuresis: experience with long-term use of intranasally administered desmopressin. J Pediatr. 1989 Apr;114(4 Pt 2):723–726. doi: 10.1016/s0022-3476(89)80888-1. [DOI] [PubMed] [Google Scholar]
  20. Post E. M., Richman R. A., Blackett P. R., Duncan K. P., Miller K. Desmopressin response of enuretic children. Effects of age and frequency of enuresis. Am J Dis Child. 1983 Oct;137(10):962–963. doi: 10.1001/archpedi.1983.02140360026009. [DOI] [PubMed] [Google Scholar]
  21. Ramsden P. D., Hindmarsh J. R., Price D. A., Yeates W. K., Bowditch J. D. DDAVP for adult enuresis--a preliminary report. Br J Urol. 1982 Jun;54(3):256–258. doi: 10.1111/j.1464-410x.1982.tb06970.x. [DOI] [PubMed] [Google Scholar]
  22. Rew D. A., Rundle J. S. Assessment of the safety of regular DDAVP therapy in primary nocturnal enuresis. Br J Urol. 1989 Apr;63(4):352–353. doi: 10.1111/j.1464-410x.1989.tb05215.x. [DOI] [PubMed] [Google Scholar]
  23. Simmonds E. J., Mahony M. J., Little J. M. Convulsion and coma after intranasal desmopressin in cystic fibrosis. BMJ. 1988 Dec 17;297(6663):1614–1614. doi: 10.1136/bmj.297.6663.1614. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Sukhai R. N., Mol J., Harris A. S. Combined therapy of enuresis alarm and desmopressin in the treatment of nocturnal enuresis. Eur J Pediatr. 1989 Feb;148(5):465–467. doi: 10.1007/BF00595916. [DOI] [PubMed] [Google Scholar]
  25. Terho P. Desmopressin in nocturnal enuresis. J Urol. 1991 Apr;145(4):818–820. doi: 10.1016/s0022-5347(17)38461-6. [DOI] [PubMed] [Google Scholar]
  26. Treatment of nocturnal enuresis. Proceedings of a symposium. August 6, 1988. J Pediatr. 1989 Apr;114(4 Pt 2):687–726. [PubMed] [Google Scholar]
  27. Tuvemo T. DDAVP in childhood nocturnal enuresis. Acta Paediatr Scand. 1978 Nov;67(6):753–755. doi: 10.1111/j.1651-2227.1978.tb16255.x. [DOI] [PubMed] [Google Scholar]
  28. Wille S. Comparison of desmopressin and enuresis alarm for nocturnal enuresis. Arch Dis Child. 1986 Jan;61(1):30–33. doi: 10.1136/adc.61.1.30. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Yaouyanc G., Jonville A. P., Yaouyanc-Lapalle H., Barbier P., Dutertre J. P., Autret E. Seizure with hyponatremia in a child prescribed desmopressin for nocturnal enuresis. J Toxicol Clin Toxicol. 1992;30(4):637–641. doi: 10.3109/15563659209017947. [DOI] [PubMed] [Google Scholar]

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