Abstract
Hypercalcemia is a frequent manifestation of human T-cell lymphotrophic virus type I (HTLV-I)-associated adult T-cell leukemia/lymphoma (ATL). Human T-cell lymphotrophic virus type I infection is endemic in the Caribbean, Japan, Melanesia, and Africa. This article presents two cases of ATL to increase awareness of the disease by primary care physicians. The management of hypercalcemia is discussed.
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- Blayney D. W., Jaffe E. S., Fisher R. I., Schechter G. P., Cossman J., Robert-Guroff M., Kalyanaraman V. S., Blattner W. A., Gallo R. C. The human T-cell leukemia/lymphoma virus, lymphoma, lytic bone lesions, and hypercalcemia. Ann Intern Med. 1983 Feb;98(2):144–151. doi: 10.7326/0003-4819-98-2-144. [DOI] [PubMed] [Google Scholar]
- DePamphilis M. L. Origins of DNA replication in metazoan chromosomes. J Biol Chem. 1993 Jan 5;268(1):1–4. [PubMed] [Google Scholar]
- Dodd R. C., Winkler C. F., Williams M. E., Bunn P. A., Gray T. K. Calcitriol levels in hypercalcemic patients with adult T-cell lymphoma. Arch Intern Med. 1986 Oct;146(10):1971–1972. [PubMed] [Google Scholar]
- Fukumoto S., Matsumoto T., Ikeda K., Yamashita T., Watanabe T., Yamaguchi K., Kiyokawa T., Takatsuki K., Shibuya N., Ogata E. Clinical evaluation of calcium metabolism in adult T-cell leukemia/lymphoma. Arch Intern Med. 1988 Apr;148(4):921–925. [PubMed] [Google Scholar]
- Ikeda K., Okazaki R., Inoue D., Ohno H., Ogata E., Matsumoto T. Interleukin-2 increases production and secretion of parathyroid hormone-related peptide by human T cell leukemia virus type I-infected T cells: possible role in hypercalcemia associated with adult T cell leukemia. Endocrinology. 1993 Jun;132(6):2551–2556. doi: 10.1210/endo.132.6.8099324. [DOI] [PubMed] [Google Scholar]
- Moseley J. M., Danks J. A., Grill V., Lister T. A., Horton M. A. Immunocytochemical demonstration of PTHrP protein in neoplastic tissue of HTLV-1 positive human adult T cell leukaemia/lymphoma: implications for the mechanism of hypercalcaemia. Br J Cancer. 1991 Oct;64(4):745–748. doi: 10.1038/bjc.1991.391. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Motokura T., Fukumoto S., Matsumoto T., Takahashi S., Fujita A., Yamashita T., Igarashi T., Ogata E. Parathyroid hormone-related protein in adult T-cell leukemia-lymphoma. Ann Intern Med. 1989 Sep 15;111(6):484–488. doi: 10.7326/0003-4819-111-6-484. [DOI] [PubMed] [Google Scholar]
- Poiesz B. J., Ruscetti F. W., Gazdar A. F., Bunn P. A., Minna J. D., Gallo R. C. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci U S A. 1980 Dec;77(12):7415–7419. doi: 10.1073/pnas.77.12.7415. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Raney B., Schnaufer L., Ziegler M., Chatten J., Littman P., Jarrett P. Treatment of children with neurogenic sarcoma. Experience at the Children's Hospital of Philadelphia, 1958-1984. Cancer. 1987 Jan 1;59(1):1–5. doi: 10.1002/1097-0142(19870101)59:1<1::aid-cncr2820590105>3.0.co;2-a. [DOI] [PubMed] [Google Scholar]