Abstract
This article describes a case of spontaneous neonatal intestinal perforation in a preterm infant with evidence of intrauterine exposure to cocaine. Clinical, laboratory, radiological, surgical, and pathological finds were inconsistent with necrotizing enterocolitis. Three previous case reports had made the association between spontaneous focal neonatal intestinal perforation and prior intrauterine cocaine exposure; however, in each case, there were extenuating circumstances that may weaken the etiological link. The case described here appears to strengthen the association/etiological link. After all other causes of focal neonatal intestinal perforation have been excluded, the possibility of intrauterine exposure to cocaine should be considered.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Buchheit J. Q., Stewart D. L. Clinical comparison of localized intestinal perforation and necrotizing enterocolitis in neonates. Pediatrics. 1994 Jan;93(1):32–36. [PubMed] [Google Scholar]
- Fang D. H., Hwang R. C., Liou C. Y., Yeh M. H., Chu M. L. [Neonatal bowel perforation successfully treated by conservative treatment: report of two cases]. Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi. 1992 Mar-Apr;33(2):148–154. [PubMed] [Google Scholar]
- Hall T. R., Zaninović A., Lewin D., Barrett C., Boechat M. I. Neonatal intestinal ischemia with bowel perforation: an in utero complication of maternal cocaine abuse. AJR Am J Roentgenol. 1992 Jun;158(6):1303–1304. doi: 10.2214/ajr.158.6.1590129. [DOI] [PubMed] [Google Scholar]
- Kubista T. P., Lynn H. B., Dahlin D. C., DuShane J. W. Spontaneous perforation of the colon in the newborn. Mayo Clin Proc. 1970 Feb;45(2):103–113. [PubMed] [Google Scholar]
- Miller B. M., Rosario P. G., Prakash K., Patel H. K., Gerst P. H. Neonatal intestinal perforation: the "crack" connection. Am J Gastroenterol. 1990 Jun;85(6):767–769. [PubMed] [Google Scholar]
- Spinazzola R., Kenigsberg K., Usmani S. S., Harper R. G. Neonatal gastrointestinal complications of maternal cocaine abuse. N Y State J Med. 1992 Jan;92(1):22–23. [PubMed] [Google Scholar]
- Weinberg G., Kleinhaus S., Boley S. J. Idiopathic intestinal perforations in the newborn: an increasingly common entity. J Pediatr Surg. 1989 Oct;24(10):1007–1008. doi: 10.1016/s0022-3468(89)80203-9. [DOI] [PubMed] [Google Scholar]