Abstract
Cytomegalovirus retinitis is the leading cause of blindness in adults and children with acquired immunodeficiency syndrome (AIDS). Although clinical trials on therapy exist for adults, management of cytomegalovirus retinitis in children is not as well-documented. This report describes the clinical course of a 3-year-old child with cytomegalovirus retinitis. After initial failure with single-agent ganciclovir intravenous treatment, early institution of combined treatment with foscarnet and ganciclovir halted progression of the retinitis. This case report highlights the aggressive nature of cytomegalovirus retinitis in children and the consideration of early combined therapy compared to adult patients.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Butler K. M., De Smet M. D., Husson R. N., Mueller B., Manjunath K., Montrella K., Lovato G., Jarosinski P., Nussenblatt R. B., Pizzo P. A. Treatment of aggressive cytomegalovirus retinitis with ganciclovir in combination with foscarnet in a child infected with human immunodeficiency virus. J Pediatr. 1992 Mar;120(3):483–486. doi: 10.1016/s0022-3476(05)80926-6. [DOI] [PubMed] [Google Scholar]
- Dennehy P. J., Warman R., Flynn J. T., Scott G. B., Mastrucci M. T. Ocular manifestations in pediatric patients with acquired immunodeficiency syndrome. Arch Ophthalmol. 1989 Jul;107(7):978–982. doi: 10.1001/archopht.1989.01070020040025. [DOI] [PubMed] [Google Scholar]
- Flores-Aguilar M., Kuppermann B. D., Quiceno J. I., Dankner W. M., Wolf D. G., Capparelli E. V., Connor J. D., Sherwood C. H., Fullerton S., Gambertoglio J. G. Pathophysiology and treatment of clinically resistant cytomegalovirus retinitis. Ophthalmology. 1993 Jul;100(7):1022–1031. doi: 10.1016/s0161-6420(93)31523-x. [DOI] [PubMed] [Google Scholar]
- Jacobson M. A., Kramer F., Bassiakos Y., Hooton T., Polsky B., Geheb H., O'Donnell J. J., Walker J. D., Korvick J. A., van der Horst C. Randomized phase I trial of two different combination foscarnet and ganciclovir chronic maintenance therapy regimens for AIDS patients with cytomegalovirus retinitis: AIDS clinical Trials Group Protocol 151. J Infect Dis. 1994 Jul;170(1):189–193. doi: 10.1093/infdis/170.1.189. [DOI] [PubMed] [Google Scholar]