Skip to main content
Journal of the National Medical Association logoLink to Journal of the National Medical Association
. 1996 Dec;88(12):774–778.

The effects of calcium supplementation on ambulatory blood pressure in African-American adolescents.

I J Davis 1, C Grim 1, K Dwyer 1, L Nicholson 1, J Dwyer 1
PMCID: PMC2608140  PMID: 8990802

Abstract

This longitudinal trial investigated the effects of calcium supplementation on the mean 24-hour blood pressure in African-American adolescents. Subjects were self-identified African-American adolescents from a high school in a suburb of Los Angeles, California. The subjects were randomly placed in a placebo or treatment group (placebo versus 1.5 g of calcium/day x 4 weeks). Follow-up mean 24-hour ambulatory blood pressure (ABP) for both the treatment and control groups was lower than the baseline mean 24-hour ABP. In the treatment group, there was a decrease of 2.2 mm Hg in the mean systolic blood pressure and 0.7 mm Hg in the diastolic blood pressure. Relative to the placebo group, the net change in ABP was -1.7 mm Hg for systolic blood pressure and -0.5 mm Hg for the diastolic blood pressure. There was no statistically significant effect of calcium supplementation on the 24-hour mean ABP. The net effect of supplementation on ABP during waking and sleeping hours also was not significant.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cappuccio F. P., Siani A., Strazzullo P. Oral calcium supplementation and blood pressure: an overview of randomized controlled trials. J Hypertens. 1989 Dec;7(12):941–946. doi: 10.1097/00004872-198912000-00003. [DOI] [PubMed] [Google Scholar]
  2. Cutler J. A., Brittain E. Calcium and blood pressure. An epidemiologic perspective. Am J Hypertens. 1990 Aug;3(8 Pt 2):137S–146S. doi: 10.1093/ajh/3.8.137. [DOI] [PubMed] [Google Scholar]
  3. Gillum R. F. Pathophysiology of hypertension in blacks and whites. A review of the basis of racial blood pressure differences. Hypertension. 1979 Sep-Oct;1(5):468–475. doi: 10.1161/01.hyp.1.5.468. [DOI] [PubMed] [Google Scholar]
  4. Grobbee D. E., Hofman A. Effect of calcium supplementation on diastolic blood pressure in young people with mild hypertension. Lancet. 1986 Sep 27;2(8509):703–707. doi: 10.1016/s0140-6736(86)90228-x. [DOI] [PubMed] [Google Scholar]
  5. Harshfield G. A., Pulliam D. A., Alpert B. S., Stapleton F. B., Willey E. S., Somes G. W. Ambulatory blood pressure patterns in children and adolescents: influence of renin-sodium profiles. Pediatrics. 1991 Jan;87(1):94–100. [PubMed] [Google Scholar]
  6. Keane T. M., Martin J. E., Berler E. S., Wooten L. S., Fleece E. L., Williams J. G. Are hypertensives less assertive? A controlled evaluation. J Consult Clin Psychol. 1982 Aug;50(4):499–508. doi: 10.1037//0022-006x.50.4.499. [DOI] [PubMed] [Google Scholar]
  7. Klag M. J., Whelton P. K., Coresh J., Grim C. E., Kuller L. H. The association of skin color with blood pressure in US blacks with low socioeconomic status. JAMA. 1991 Feb 6;265(5):599–602. [PubMed] [Google Scholar]
  8. Klein W., Zweiker R., Eber B., Dusleag J., Brussee H., Rotman B. Circadian blood pressure pattern in patients with treated hypertension and left ventricular hypertrophy. Angiology. 1991 May;42(5):379–386. doi: 10.1177/000331979104200505. [DOI] [PubMed] [Google Scholar]
  9. Liebman M., Chopin L. F., Carter E., Clark A. J., Disney G. W., Hegsted M., Kenney M. A., Kirmani Z. A., Koonce K. L., Korslund M. K. Factors related to blood pressure in a biracial adolescent female population. Hypertension. 1986 Oct;8(10):843–850. doi: 10.1161/01.hyp.8.10.843. [DOI] [PubMed] [Google Scholar]
  10. McCarron D. A. Calcium metabolism and hypertension. Kidney Int. 1989 Feb;35(2):717–736. doi: 10.1038/ki.1989.44. [DOI] [PubMed] [Google Scholar]
  11. McCarron D. A., Morris C. D. Blood pressure response to oral calcium in persons with mild to moderate hypertension. A randomized, double-blind, placebo-controlled, crossover trial. Ann Intern Med. 1985 Dec;103(6 ):825–831. doi: 10.7326/0003-4819-103-6-825. [DOI] [PubMed] [Google Scholar]
  12. Mikami H., Ogihara T., Tabuchi Y. Blood pressure response to dietary calcium intervention in humans. Am J Hypertens. 1990 Aug;3(8 Pt 2):147S–151S. doi: 10.1093/ajh/3.8.147. [DOI] [PubMed] [Google Scholar]
  13. Schneiderman N. Ethnicity and ambulatory blood pressure measurement: relationship to clinic and laboratory measurements. J Clin Pharmacol. 1992 Jul;32(7):604–609. doi: 10.1002/j.1552-4604.1992.tb05768.x. [DOI] [PubMed] [Google Scholar]
  14. Schull W. J., Harburg E., Schork M. A., Chakraborty R. Heredity, stress and blood pressure, a family set method: epilogue. J Chronic Dis. 1977 Oct;30(10):701–704. doi: 10.1016/0021-9681(77)90026-1. [DOI] [PubMed] [Google Scholar]
  15. Sempos C., Cooper R., Kovar M. G., Johnson C., Drizd T., Yetley E. Dietary calcium and blood pressure in National Health and Nutrition Examination Surveys I and II. Hypertension. 1986 Nov;8(11):1067–1074. doi: 10.1161/01.hyp.8.11.1067. [DOI] [PubMed] [Google Scholar]
  16. Sowers J. R., Zemel M. B., Zemel P., Beck F. W., Walsh M. F., Zawada E. T. Salt sensitivity in blacks. Salt intake and natriuretic substances. Hypertension. 1988 Nov;12(5):485–490. doi: 10.1161/01.hyp.12.5.485. [DOI] [PubMed] [Google Scholar]
  17. Takagi Y., Fukase M., Takata S., Fujimi T., Fujita T. Calcium treatment of essential hypertension in elderly patients evaluated by 24 H monitoring. Am J Hypertens. 1991 Oct;4(10 Pt 1):836–839. doi: 10.1093/ajh/4.10.836. [DOI] [PubMed] [Google Scholar]
  18. Williams R. R., Hopkins P. N. Salt, hypertension, and genetic-environmental interactions. Prog Clin Biol Res. 1979;32:183–194. [PubMed] [Google Scholar]

Articles from Journal of the National Medical Association are provided here courtesy of National Medical Association

RESOURCES