Skip to main content
PMC home page
Infection and Immunity logoLink to Infection and Immunity
. 1986 Sep;53(3):628–630. doi: 10.1128/iai.53.3.628-630.1986

Recombinant human gamma interferon inhibits simian malaria.

R K Maheshwari, C W Czarniecki, G P Dutta, S K Puri, B N Dhawan, R M Friedman
PMCID: PMC260838  PMID: 3091507

Abstract

Prophylactic treatment with 0.1 mg of human gamma interferon per kg (body weight) per day completely suppressed experimental infection with Plasmodium cynomolgi B sporozoites in rhesus monkeys. Treatment with lower doses partially suppressed this infection. Prophylactic treatment with human gamma interferon, however, had no protective effect against trophozoite-induced infection, suggesting that the interferon effect was limited to the exoerythrocytic stage of parasitic development.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Gober L. L., Friedman-Kien A. E., Havell E. A., Vilcek J. Suppression of the intracellular growth of Shigella flexneri in cell cultures by interferon preparations and polyinosinic-polycytidylic acid. Infect Immun. 1972 Mar;5(3):370–376. doi: 10.1128/iai.5.3.370-376.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Gray P. W., Leung D. W., Pennica D., Yelverton E., Najarian R., Simonsen C. C., Derynck R., Sherwood P. J., Wallace D. M., Berger S. L. Expression of human immune interferon cDNA in E. coli and monkey cells. Nature. 1982 Feb 11;295(5849):503–508. doi: 10.1038/295503a0. [DOI] [PubMed] [Google Scholar]
  3. Jahiel R. I., Nussenzweig R. S., Vanderberg J., Vilcek J. Anti-malarial effect of interferon inducers at different stages of development of Plasmodium berghei in the mouse. Nature. 1968 Nov 16;220(5168):710–711. doi: 10.1038/220710a0. [DOI] [PubMed] [Google Scholar]
  4. Jahiel R. I., Nussenzweig R. S., Vilcek J., Vanderberg J. Protective effect of interferon inducers on Plasmodium berghei malaria. Am J Trop Med Hyg. 1969 Nov;18(6):823–835. doi: 10.4269/ajtmh.1969.18.823. [DOI] [PubMed] [Google Scholar]
  5. Jahiel R. I., Vilcek J., Nussenzweig R. S. Exogenous interferon protects mice against Plasmodium berghei malaria. Nature. 1970 Sep 26;227(5265):1350–1351. doi: 10.1038/2271350a0. [DOI] [PubMed] [Google Scholar]
  6. Jahiel R. I., Vilcek J., Nussenzweig R., Vanderberg J. Interferon inducers protect mice against plasmodium berghei malaria. Science. 1968 Aug 23;161(3843):802–804. doi: 10.1126/science.161.3843.802. [DOI] [PubMed] [Google Scholar]
  7. Kiderlen A. F., Kaufmann S. H., Lohmann-Matthes M. L. Protection of mice against the intracellular bacterium Listeria monocytogenes by recombinant immune interferon. Eur J Immunol. 1984 Oct;14(10):964–967. doi: 10.1002/eji.1830141019. [DOI] [PubMed] [Google Scholar]
  8. Kurzrock R., Rosenblum M. G., Sherwin S. A., Rios A., Talpaz M., Quesada J. R., Gutterman J. U. Pharmacokinetics, single-dose tolerance, and biological activity of recombinant gamma-interferon in cancer patients. Cancer Res. 1985 Jun;45(6):2866–2872. [PubMed] [Google Scholar]
  9. Merigan T. C. Human interferon as a therapeutic agent. N Engl J Med. 1979 Jan 4;300(1):42–43. doi: 10.1056/NEJM197901043000113. [DOI] [PubMed] [Google Scholar]
  10. Murray H. W., Rubin B. Y., Rothermel C. D. Killing of intracellular Leishmania donovani by lymphokine-stimulated human mononuclear phagocytes. Evidence that interferon-gamma is the activating lymphokine. J Clin Invest. 1983 Oct;72(4):1506–1510. doi: 10.1172/JCI111107. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Pfefferkorn E. R., Guyre P. M. Inhibition of growth of Toxoplasma gondii in cultured fibroblasts by human recombinant gamma interferon. Infect Immun. 1984 May;44(2):211–216. doi: 10.1128/iai.44.2.211-216.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Remington J. S., Merigan T. C. Interferon: protection of cells infected with an intracellular protozoan (Toxoplasma gondii). Science. 1968 Aug 23;161(3843):804–806. doi: 10.1126/science.161.3843.804. [DOI] [PubMed] [Google Scholar]
  13. SHORTT H. E. History of recent researches on tissue phases of the malaria parasite at the London School of Hygiene and Tropical Medicine. Trans R Soc Trop Med Hyg. 1951 Oct;45(2):175–188. doi: 10.1016/s0035-9203(51)90885-1. [DOI] [PubMed] [Google Scholar]
  14. Schultz W. W., Huang K. Y., Gordon F. B. Role of interferon in experimental mouse malaria. Nature. 1968 Nov 16;220(5168):709–710. doi: 10.1038/220709a0. [DOI] [PubMed] [Google Scholar]
  15. Sueltenfuss E. A., Pollard M. Cytochemical Assay of Interferon Produced by Duck Hepatitis Virus. Science. 1963 Feb 15;139(3555):595–596. doi: 10.1126/science.139.3555.595. [DOI] [PubMed] [Google Scholar]
  16. TARLOV A. R., BREWER G. J., CARSON P. E., ALVING A. S. Primaquine sensitivity. Glucose-6-phosphate dehydrogenase deficiency: an inborn error of metabolism of medical and biological significance. Arch Intern Med. 1962 Feb;109:209–234. doi: 10.1001/archinte.1962.03620140081013. [DOI] [PubMed] [Google Scholar]
  17. Turco J., Thompson H. A., Winkler H. H. Interferon-gamma inhibits growth of Coxiella burnetii in mouse fibroblasts. Infect Immun. 1984 Sep;45(3):781–783. doi: 10.1128/iai.45.3.781-783.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Turco J., Winkler H. H. Cloned mouse interferon-gamma inhibits the growth of Rickettsia prowazekii in cultured mouse fibroblasts. J Exp Med. 1983 Dec 1;158(6):2159–2164. doi: 10.1084/jem.158.6.2159. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. de la Maza L. M., Peterson E. M., Goebel J. M., Fennie C. W., Czarniecki C. W. Interferon-induced inhibition of Chlamydia trachomatis: dissociation from antiviral and antiproliferative effects. Infect Immun. 1985 Mar;47(3):719–722. doi: 10.1128/iai.47.3.719-722.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES