Skip to main content
NCBI home page
Journal of the National Medical Association logoLink to Journal of the National Medical Association
. 1999 Aug;91(8):453–456.

Effect of methylprednisolone on coagulation.

H B Pandit 1, C R Spillert 1
PMCID: PMC2608443  PMID: 12656434

Abstract

This in vitro study examined the effects of methylprednisolone on coagulation status. Venous blood samples were collected from 12 adult subjects including healthy volunteers and patients presenting to the emergency department and analyzed for coagulation changes using the modified recalcification time (MRT) test prior to and after the addition of methylprednisolone. Mean +/- SD MRT control values before the addition of methylprednisolone (MRTC) and after (MRTCP) were 5.4 +/- 1.5 and 5.7 +/- 1.3 minutes, respectively. The MRT saline values prior to treatment with methylprednisolone (MRTS) and after (MRTSP) were 5.6 +/- 1.2 and 5.4 +/- 1.1 minutes, respectively. The MRT endotoxin prior to the introduction of steroid (MRTE) and after its addition (MRTEP) were 3.8 +/- 0.8 and 5.2 +/- 1.4 minutes, respectively. The MRTE values in the presence of methylprednisolone were significantly different between groups. This may suggest that the monocyte-stimulated release of the procoagulant tissue factor is inhibited by the corticosteroid, causing the blood to be relatively hypocoagulable.

Full text

PDF
453

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CHATTERJEA J. B., SALOMON L. Antagonistic effect of A.C.T.H. and cortisone on the anticoagulant activity of ethyl biscoumacetate. Br Med J. 1954 Oct 2;2(4891):790–792. doi: 10.1136/bmj.2.4891.790. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. COSGRIFF S. W., DIEFENBACH A. F., VOGT W., Jr Hypercoagulability of the blood associated with ACTH and cortisone therapy. Am J Med. 1950 Dec;9(6):752–756. doi: 10.1016/0002-9343(50)90290-7. [DOI] [PubMed] [Google Scholar]
  3. COSGRIFF S. W. Thromboembolic complications associated with ACTH and cortisone therapy. J Am Med Assoc. 1951 Nov 3;147(10):924–926. doi: 10.1001/jama.1951.03670270014006. [DOI] [PubMed] [Google Scholar]
  4. Dasmahapatra K. S., Cheung N. K., Spillert C., Lazaro E. An assessment of monocyte procoagulant activity in patients with solid tumors. J Surg Res. 1987 Aug;43(2):158–163. doi: 10.1016/0022-4804(87)90159-4. [DOI] [PubMed] [Google Scholar]
  5. Gin W., Kay A. B. The effect of corticosteroids on monocyte and neutrophil activation in bronchial asthma. J Allergy Clin Immunol. 1985 Nov;76(5):675–682. doi: 10.1016/0091-6749(85)90670-0. [DOI] [PubMed] [Google Scholar]
  6. Hirsh J., Spillert C. R., Delle Donne E. P., Lazaro E. J. In vitro effect of hirudin on recalcification time. J Natl Med Assoc. 1994 Aug;86(8):627–628. [PMC free article] [PubMed] [Google Scholar]
  7. Lazaro E. J., Spillert C. R., Ponnudurai R. N., Thayer K. J. Is it time to change the prothrombin time? Surgery. 1995 Nov;118(5):912–913. doi: 10.1016/s0039-6060(05)80286-7. [DOI] [PubMed] [Google Scholar]
  8. Lyberg T. Clinical significance of increased thromboplastin activity on the monocyte surface--a brief review. Haemostasis. 1984;14(5):430–439. doi: 10.1159/000215101. [DOI] [PubMed] [Google Scholar]
  9. Mukherjee A. P., Toh B. H., Chan G. L., Lau K. S., White J. C. Vasculas complications in nephrotic syndrome: relationship to steroid therapy and accelerated thromboplastin generation. Br Med J. 1970 Oct 31;4(5730):273–276. doi: 10.1136/bmj.4.5730.273. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. OZSOYLU S., STRAUSS H. S., DIAMOND L. K. Effects of corticosteroids on coagulation of the blood. Nature. 1962 Sep 22;195:1214–1215. doi: 10.1038/1951214a0. [DOI] [PubMed] [Google Scholar]
  11. Prydz H., Allison A. C. Tissue thromboplastin activity of isolated human monocytes. Thromb Haemost. 1978 Jun 30;39(3):582–591. [PubMed] [Google Scholar]
  12. Rinehart J. J., Sagone A. L., Balcerzak S. P., Ackerman G. A., LoBuglio A. F. Effects of corticosteroid therapy on human monocyte function. N Engl J Med. 1975 Jan 30;292(5):236–241. doi: 10.1056/NEJM197501302920504. [DOI] [PubMed] [Google Scholar]
  13. SMITH R. W., MARGULIS R. R., BRENNAN M. J., MONTO R. W. The influence of ACTH and cortisone on certain factors of blood coagulation. Science. 1950 Sep 15;112(2907):295–297. doi: 10.1126/science.112.2907.295. [DOI] [PubMed] [Google Scholar]
  14. Schreiber A. D., Parsons J., McDermott P., Cooper R. A. Effect of corticosteroids on the human monocyte IgG and complement receptors. J Clin Invest. 1975 Nov;56(5):1189–1197. doi: 10.1172/JCI108196. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Sofia C. A., Spillert C. R., Pastena J. A., Lazaro E. J. Recalcification time in breast disease. J Natl Med Assoc. 1988 Nov;80(11):1214–1216. [PMC free article] [PubMed] [Google Scholar]
  16. Spillert C. R., Lazaro E. J. Modified recalcification time: a global coagulation screening test. J Natl Med Assoc. 1993 Aug;85(8):611–616. [PMC free article] [PubMed] [Google Scholar]
  17. Spillert C. R., Lazaro E. J. Shortened endotoxin-activated clotting times in patients with carcinoma. Am Surg. 1987 Mar;53(3):164–166. [PubMed] [Google Scholar]
  18. Spillert C. R., Milazzo V. J., Pastena J. A., Lazaro E. J. Prediction of clinical course in diabetes using a simple coagulation test. J Natl Med Assoc. 1989 Jan;81(1):81–83. [PMC free article] [PubMed] [Google Scholar]
  19. Spillert C. R., Milazzo V. J., Suval W. D., Lazaro E. J. Hypercoagulability in arterial disease. Angiology. 1989 Oct;40(10):886–889. doi: 10.1177/000331978904001005. [DOI] [PubMed] [Google Scholar]

Articles from Journal of the National Medical Association are provided here courtesy of National Medical Association

RESOURCES