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. 1986 Sep;53(3):693–696. doi: 10.1128/iai.53.3.693-696.1986

Receptor-binding function of type 1 pili effects bladder colonization by a clinical isolate of Escherichia coli.

B R Keith, L Maurer, P A Spears, P E Orndorff
PMCID: PMC260849  PMID: 2875030

Abstract

The role of type 1 pili in promoting bladder colonization was examined by constructing two mutant strains of a clinical Escherichia coli isolate. One mutant was isogenic to the parental strain save for a lesion in a gene required for pilus receptor binding; the other mutant was isogenic save for a lesion in the gene encoding the pilus structural subunit. Using mixed infections of the parental and mutant strains in an ascending rat cystitis model, we found that type 1-piliated mutants that lacked the receptor-binding function were as ineffective in bladder colonization as were mutants lacking the entire organelle.

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Selected References

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