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. 1986 Sep;53(3):711–712. doi: 10.1128/iai.53.3.711-712.1986

Effect of monophosphoryl lipid A on host resistance to bacterial infection.

J J Chase, W Kubey, M H Dulek, C J Holmes, M G Salit, F C Pearson 3rd, E Ribi
PMCID: PMC260854  PMID: 3744562

Abstract

The ability of monophosphoryl lipid A (MPLA) to enhance nonspecific host resistance to bacterial infections was studied. Mice were treated with MPLA prior to intraperitoneal challenge with Escherichia coli or Staphylococcus epidermidis. Animals received additional MPLA for 2 days postinfection, and survival rates were determined. Ten micrograms of MPLA per mouse significantly improved the survival of animals infected with either bacterial species. Dose-response studies showed significant MPLA-induced protection at doses of 6 micrograms/kg against E. coli challenge and 60 micrograms/kg against S. epidermidis challenge.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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